Angelman Syndrome Research and Treatment Center
The Angelman Syndrome Research and Treatment Center at Cincinnati Children’s serves people of all ages who have Angelman Syndrome (AS) or Dup15q Syndrome. The center is within our Division of Psychiatry.
Call 513-803-1150 to learn more or to refer a patient.
What is Angelman Syndrome?
AS is a rare genetic disorder that impacts brain function and development. About 1 in 15,000 people around the world have AS. Dup15 Syndrome is another neuro-genetic disorder. You may see it paired with AS for research because changes in the same region of chromosome 15 cause both conditions.
People receive an AS diagnosis through a DNA (blood) test. Symptoms associated with AS vary, but the most common include:
- Developmental delays
- Feeding difficulties or constipation
- Movement disorders
- Sleep difficulties
- Speech impairments
Our approach to Angelman Syndrome
Currently, there is no cure for AS. So, at our center, we focus treatment on managing symptoms. We personalize treatment for each patient—with access to a variety of providers from different specialties.
Families can expect:
- Behavior and cognitive assessments
- Behavior interventions
- Connections to neurology, especially for those with epilepsy or myoclonus
- Education about AS and how to care for someone with AS
- Medication management for behavior symptoms
- Referrals to other services at Cincinnati Children’s, such as:
Angelman Syndrome Research
We strive to learn as much as we can about AS. Our researchers work each day toward finding effective treatments and even a cure.
We’re part of Linking Angelman and Dup15q Data for Expanded Research (LADDER)—a joint effort between the Angelman Syndrome Foundation and the Dup15q Alliance. LADDER is a database that compiles research about AS and Dup15q. By centralizing information about AS, we help improve our understanding of this disease. And that means a better chance of future discoveries that lead to clinical trials and treatments.
