Addressing Critical Illness with a Basic through Translational Approach

Critical Care researchers are exploring ways to identify and modify the biological processes that impact critical illness. Our basic research scientists come from diverse scientific disciplines, each contributing their unique perspective. Through scientific inquiry and collaboration, they are advancing the field of critical care medicine to find new ways to prevent and treat sepsis, the major cause of mortality in critically ill children.

Our basic researchers collaborate with colleagues throughout the medical center, including the hospital’s Center for Stem Cell and Organoid Medicine (CuSTOM). Areas of focus include:

• Understanding the immune system response to infection and inflammation
• The role of metabolism and mitochondrial function in critical illness
• Mitigators and influencers of the development of ARDS
• The role of vascular dysfunction in multiorgan injury
• The use of organoids to model the impact of critical illness of organ function

Researchers

Matthew Alder, MD, PhD 

Steve Standage, MD

Basilia Zingarelli, MD, PhD

Andrew Lautz, MD

Mihir Atreya, MD, MPH

Jennifer Kaplan, MD, MS

Brian Varisco, MD