Supporting Scientific Discovery Through Our Biorepository

The Division of Critical Care Medicine’s biorepository supports risk stratification research for sepsis patients. The biorepository’s robust database has served as the backbone for hundreds of research studies. It is available to anyone at Cincinnati Children’s who is conducting basic, clinical or translational research. Researchers from other institutions also can access the biorepository when collaborating with Cincinnati Children’s on research projects.

The biorepository collects clinical data, blood, plasma, serum, urine and lung tissue. It provides genomic analysis using the PERSEVERE biomarker panel developed by long-time Division Director Hector Wong, MD, who died in 2022. PERSEVERE (Pediatric Sepsis Biomarker Risk Model) is a biomarker-based stratification tool that uses genome-wide expression profiling to estimate a specific patient’s baseline mortality risk from sepsis.

The biorepository is a valuable resource that is continually expanding to better serve scientists. Future plans include using the biorepository to collect and analyze additional materials, such as patient-derived stem cells and exosomes.

Contact Basilia Zingarelli, MD, PhD, director of critical care basic science research, to learn more about the biorepository.