Translational Imaging and Modeling Research

Our imaging and modeling capabilities in the Division of Pulmonary Medicine research are world class. We have pioneered the use of hyperpolarized Xenon Magnetic Resonance Imaging (Xe MRI) and have performed important dynamic-airway computational fluid dynamics calculations in pediatrics. We have six faculty members who focus on imaging and modeling. Some of our disease focus areas include cystic fibrosis, asthma, bronchopulmonary dysplasia (BPD), and post-transplant bronchiolitis obliterans.

Some of our many highlights involve the world's first virtual models of human airways that move realistically, based on motion in high-speed magnetic resonance imaging, pioneered by Nara Higano, PhD. This moving airway has allowed Alister Bates, PhD, to model airflow in the large airway, using computational fluid dynamics, and predict the work of breathing as a result of airway abnormalities. The combination of airway and parenchymal imaging has been particularly useful in neonates with chronic lung disease, as has been demonstrated by Higano and Erik Hysinger, MD, MS.

Hyperpolarized gas MRI allows visualization and quantification of regional ventilation, alveolar-airspace size, and gas exchange. Laura Walkup, PhD, has used the technique to study rare-lung diseases and post-transplant populations, and Jason Woods, PhD’s studies have focused on the effect of new and existing treatments for cystic fibrosis and BPD. New treatments for fibrotic conditions have been explored by Zackary Cleveland, PhD, who also leads all of our preclinical imaging efforts.

For more information on this work, please visit the Center for Pulmonary Imaging Research (CPIR).