Zackary I. Cleveland, PhD

Associate Director, Center for Pulmonary Imaging Research
Associate Professor, UC Department of Pediatrics
UC Department of Biomedical Engineering

zackary.cleveland@cchmc.org

About

Biography

Although hyperpolarized gases have been used to investigate regional pulmonary structure and function since the late 1990, the technology was not widely disseminated, because it relied on the rare and expensive stable isotope 3He. Dr. Cleveland helped pioneer the use of more readily available 129Xe, paving the way for clinical hyperpolarized gas MRI. Dr. Cleveland also helped expand the limits of preclinical MRI by demonstrating the feasibility of high resolution HP 129Xe imaging in rats and mice and by demonstrating the the first, in vivo molecular imaging applications of HP gases.

Services and Specialties

Cystic Fibrosis Center

Interests

Hyperpolarized gases; pulmonary imaging; translational studies; preclinical MRI

Research Areas

Pulmonary Medicine, Imaging, Fibrosis

Publications

129Xe Image Processing Pipeline: An open-source, graphical user interface application for the analysis of hyperpolarized 129Xe MRI. Bdaiwi, AS; Willmering, MM; Plummer, JW; Hussain, R; Roach, DJ; Parra-Robles, J; Niedbalski, PJ; Woods, JC; Walkup, LL; Cleveland, ZI. Magnetic Resonance in Medicine. 2025; 93:1220-1237.

A thermally polarized, dissolved-phase 129Xe phantom for quality-control and multisite comparisons of gas-exchange imaging. Willmering, MM; Albert, BJ; Plummer, JW; Greer, J; Walkup, LL; Lindquist, DM; Cleveland, ZI. Journal of Magnetic Resonance. 2025; 371:107829.

Improved Diffusion-Weighted Hyperpolarized 129Xe Lung MRI with Patch-Based Higher-Order, Singular Value Decomposition Denoising. Soderlund, SA; Bdaiwi, AS; Plummer, JW; Woods, JC; Walkup, LL; Cleveland, ZI. Academic Radiology. 2024; 31:5289-5299.

Hyperpolarized 129Xe Lung MRI and Spectroscopy in Mechanically Ventilated Mice. Costa, ML; Plummer, JW; Bdaiwi, AS; Albert, BJ; Fugate, EM; Niedbalski, PJ; Lindquist, DM; Cleveland, ZI. Jove-Journal of Visualized Experiments. 2024.

A decay-modeled compressed sensing reconstruction approach for non-Cartesian hyperpolarized 129Xe MRI. Plummer, JW; Hussain, R; Bdaiwi, AS; Soderlund, SA; Hoyos, X; Lanier, JM; Garrison, WJ; Parra-Robles, J; Willmering, MM; Niedbalski, PJ; Cleveland, ZI; Walkup, LL. Magnetic Resonance in Medicine. 2024; 92:1363-1375.

846 Plasma proteomics identifies changes in disease-associated pathways in subjects with CF bronchiectasis after elexacaftor/tezacaftor/ivacaftor initiation. Skala, E; Banerjee, R; Siefert, M; Dusa, C; Stevens, C; Hils, B; Bdaiwi, A; Hayes, D; Cleveland, Z; Ziady, A. Journal of Cystic Fibrosis. 2024; 23:s490.

Analytical corrections for B1-inhomogeneity and signal decay in multi-slice 2D spiral hyperpolarized 129Xe MRI using keyhole reconstruction. Plummer, JW; Hussain, R; Bdaiwi, AS; Costa, ML; Willmering, MM; Parra-Robles, J; Cleveland, ZI; Walkup, LL. Magnetic Resonance in Medicine. 2024; 92:967-981.

Quantifying abnormal alveolar microstructure in cystic fibrosis lung disease via hyperpolarized 129Xe diffusion MRI. Bdaiwi, AS; Svoboda, AM; Murdock, KE; Hendricks, A; Hossain, MM; Kramer, EL; Brewington, JJ; Willmering, MM; Woods, JC; Walkup, LL; Cleveland, ZI. Journal of Cystic Fibrosis. 2024; 23:926-935.

Impact of undersampling on preclinical lung T2* mapping with 3D radial UTE MRI at 7 T. Stecker, IR; Bdaiwi, AS; Niedbalski, PJ; Chatterjee, N; Hossain, MM; Cleveland, ZI. Journal of Magnetic Resonance. 2024; 365:107741.

Short-term structural and functional changes after airway clearance therapy in cystic fibrosis. West, ME; Spielberg, DR; Roach, DJ; Willmering, MM; Bdaiwi, AS; Cleveland, ZI; Woods, JC. Journal of Cystic Fibrosis. 2023; 22:926-932.