My interest in pulmonary imaging research was born of a unique background in hyperpolarized gases and atomic physics, combined with an interest in translational applications to surgery and pulmonary medicine.
My primary research areas include pulmonary MRI, regional structure-function relationships, pathophysiology, translational imaging research and clinical trials. The overall goal of this research is to improve outcomes for patients with lung disease through precise imaging and determination of regional structure-function relationships, using a combination of translational techniques and innovative methodologies.
We have pioneered 129Xe MRI in pediatrics and help lead the 129Xe MRI Clinical Trials Consortium. We also have begun to redefine bronchopulmonary dysplasia (BPD) by imaging-phenotypes, which show a direct relationship to outcomes.
Our research team is comprised of experts in hyperpolarized-gas MRI and in the use of this technique to measure regional lung function, physiology and microstructure. Many of the fellows and junior faculty that I have mentored have won awards and recognition from national and international organizations, such as the International Society for Magnetic Resonance in Medicine (ISMRM), the American Thoracic Society (ATS) and the Society for Pediatric Radiology (SPR).
Since my arrival at Cincinnati Children’s in 2013, I’ve served as the director of the Center for Pulmonary Imaging Research (CPIR). Our center offers a multidisciplinary research and training program that combines pulmonary medicine, radiology and neonatology. I also co-lead the Bronchopulmonary Dysplasia Center at Cincinnati Children’s, where imaging research has been rapidly translated into clinical care and improved patient outcomes.
PhD: Washington University, St. Louis, MO, 2002.
Postdoctoral: Washington University, St. Louis, MO, 2004.
Bronchopulmonary dysplasia
Hyperpolarized gas; pulmonary MRI; translational studies; image-guided pulmonary interventions
Pulmonary Medicine, Imaging, Fibrosis
129Xe Image Processing Pipeline: An open-source, graphical user interface application for the analysis of hyperpolarized 129Xe MRI. Magnetic Resonance in Medicine. 2025; 93:1220-1237.
New frontiers in asthma chest imaging. Journal of Allergy and Clinical Immunology. 2025; 155:241-254.e1.
High-quality FLORET UTE imaging for clinical translation. Magnetic Resonance in Medicine. 2025; 93:276-288.
Clinical Outcomes Through Two Years for Infants With Bronchopulmonary Dysplasia and Tracheomalacia. Pediatric Pulmonology. 2025; 60:e27383.
The impact of highly effective modulator therapy on sinusitis and dysosmia in young children with cystic fibrosis: a prospective study protocol. ERJ Open Research. 2025; 11:137-2024.
Magnetic Resonance Imaging Assessment of Pulmonary Vascularity in Preterm Infants with Bronchopulmonary Dysplasia. Neonatology: foetal and neonatal research. 2025; 122:76-83.
Improved Diffusion-Weighted Hyperpolarized 129Xe Lung MRI with Patch-Based Higher-Order, Singular Value Decomposition Denoising. Academic Radiology. 2024; 31:5289-5299.
Effect of airway wall motion on particle deposition and delivery in the neonatal trachea. Journal of Aerosol Science. 2024; 182:106450.
Olfactory loss in people with cystic fibrosis: Community perceptions and impact. Journal of Cystic Fibrosis. 2024; 23:1195-1198.
Correlation of Tracheomalacia Severity With Esophageal Gap Length as Assessed by Ultrashort Echo-time MRI. Journal of Pediatric Surgery. 2024; 59:161880.