Research Focus Areas
The long-term goal of the Digestive Health Center (DHC) is to improve child health through better diagnosis, treatments and outcomes for our three (3) key targeted focus areas, including:
- Mechanisms of Liver Disease
-- Biliary atresia, cholestatic syndromes, and immune -mediated diseases
-- Fatty liver disease and metabolic syndrome in children
-- Treatment of viral hepatitis in adults and children
- Digestive Disease and Immunity
-- Inflammatory bowel disease: mucosal immunology, microbial sensing
-- GI epithelium: cellular ecosystem, crosstalk, and function; mucosal permeability
-- Eosinophilic gastrointestinal disorders
- Stem Cell and Organoid Modeling of Digestive Disease
-- Molecular basis of organogenesis
-- Organoids to model physiological domains: esophagus, stomach, intestine, colon, liver, bile duct
-- iPSC- and patient-derived organoids to model GI and liver diseases
