Patents

Processing text with domain-specific spreading activation methods

Patent number: 8930178

Abstract: A method for performing natural language processing of free text using domain-specific spreading activation. Embodiments of the present invention ontologize free text using an algorithm based on neurocognitive theory by simulating human recognition, semantic, and episodic memory approaches. Embodiments of the invention may be used to process clinical text for assignment of billing codes, analyze suicide notes or legal discovery materials, and for processing other collections of text. Further, embodiments of the invention may be used to more effectively search large databases, such as a database containing a large number of medical publications.

Type: Grant

Filed: January 4, 2008

Date of Patent: January 6, 2015

Assignee: Children's Hospital Medical Center

Inventors: John Pestian, Pawel Matykiewicz, Wlodzislaw Duch, Tracy A. Glauser, Robert A. Kowatch, Jacqueline Grupp-Phelan

Optimization and Individualization of Medication Selection and Dosing

Patent number: 8589175

Abstract: The invention provides population models, methods, and algorithms for targeting a dosing regimen or compound selection to an individual patient. The methods and algorithms of the invention utilize population models that incorporate genotype information for genes encoding drug metabolizing enzymes for one or more compounds of interest. The methods allow integration of genotype information for one or more genes encoding a drug metabolizing enzyme, particularly a cytochrome P450 gene with patient data. The methods allow integration of genotype information and the effect of one or more compounds on one or more drug metabolizing enzymes. The methods allow iterative feedback of drug metabolizing data obtained from a patient into the process of generating a dosage regimen recommendation for a compound of interest for an individual patient.

Type: Grant

Filed: November 28, 2006

Date of Patent: November 19, 2013

Assignee: Children's Hospital Medical Center

Inventors: Tracy A. Glauser, Richard J. Wenstrup, Alexander A. Vinks, John Pestian

Patents - Inventor or Co-Inventor

A. Optimization and Individualization of Medication Selection and Dosing

1. United States, 8,589,175, 11/19/2014, Optimization and Individualization of Medication Selection and Dosing
2. Japan, 5567107, 06/27/2014, Optimization and Individualization of Medication Selection and Dosing
3. Belgium, 2508621BE, 11/15/2014, Optimization and Individualization of Medication Selection and Dosing
4. European Patent Office, 2508621, 11/15/2015, Optimization and Individualization of Medication Selection and Dosing
5. France, 2508621FR, 11/15/2015, Optimization and Individualization of Medication Selection and Dosing
6. Germany, 2508621DE, 11/15/2015, Optimization and Individualization of Medication Selection and Dosing
7. Italy, 2508621IT, 11/15/2015, Optimization and Individualization of Medication Selection and Dosing
8. Spain, 2508621ES, 11/15/2015, Optimization and Individualization of Medication Selection and Dosing
9. Sweden, 2508621SW, 11/15/2015, Optimization and Individualization of Medication Selection and Dosing
10. Switzerland, 2508621CH, 11/15/2015, Optimization and Individualization of Medication Selection and Dosing
11. The Netherlands, 2508621NL, 11/15/2015, Optimization and Individualization of Medication Selection and Dosing
12. United Kingdom, 2508621, 11/15/2015, Optimization and Individualization of Medication Selection and Dosing
13. Hong Kong, HK1176093, 09/04/2015, Optimization and Individualization of Medication Selection and Dosing
14. Australia, 2912293861, 11/26/2015, Optimization and Individualization of Medication Selection and Dosing
15. Canada, 2,630,604, 1/19/2016, Optimization and Individualization of Medication Selection and Dosing
16. Japan, 5894213, 3/4/2016, Optimization and Individualization of Medication Selection and Dosing
17. Canada, 2,630,604, 1/19/2016, Optimization and Individualization of Medication Selection and Dosing
18. Japan, 5894213, 3/4/2016 , Optimization and Individualization of Medication Selection and Dosing
19. Denmark 2508621, 12/30/2014 Optimization and Individualization of Medication Selection and Dosing
20. Australia 2015221486, 9/2/2015 Optimization and Individualization of Medication Selection and Dosing

B. Processing Text

1. United States, 9.477,655, 10/25/2016, Processing Text with Domain-Specific Spreading Activation Methods
2. United Statas 10,140,288 9/29/2016 Processing Text with Domain-Specific Spreading Activation Methods
3. United States, 8,930,178, 01/06/2015, Processing Text with Domain-Specific Spreading Activation Methods

C. Assessing Suicide Risk

1. United States, 9,691,411 - System and Method for Assessing Suicide Risk of a Patient Based Upon Non-Verbal Characteristics of Voice Data

Pending Patents - Inventor or Co-Inventor

A. Optimization and Individualization of Medication Selection and Dosing

1. Australia 2018201123, 2/15/2018 Optimization and Individualization of Medication Selection and Dosing
2. Canada (number not determined yet) 9/26/2019 Optimization and Individualization of Medication Selection and Dosing
3. Hong Kong 18104016.2 3/22/2018 Optimization and Individualization of Medication Selection and Dosing
4. Canada 2,911,569, 11/9/2015 Optimization and Individualization of Medication Selection and Dosing
5. Japan 2012-054497 3/2/2012 Optimization and Individualization of Medication Selection and Dosing
6. United States 15/367,950 12/2/2016 Optimization and Individualization of Medication Selection and Dosing

B. Natural Language Approaches for Identification of Neurosurgery Candidates

1. EU 14832137.5, 2/15/2016 Natural Language Approaches for Identification of Neurosurgery Candidates
2. US 14/908,084, 1/27/2016 Natural Language Approaches for Identification of Neurosurgery Candidates
3. US 16,396,835, 4/29/2019 Natural Language Approaches for Identification of Neurosurgery Candidates