Xu Lab

Xu Lab

Xu, Y; Mcmillan, A; Gupta, N; Lemke-Miltner, CD; Rataan, AO; Areecheewakul, S; Bhat, DS; Lanzel, EA; Geary, SM; Simons, AL; Weiner, GJ; Salem, AK. In situ treatment with a TLR9 agonist virus-like particle to promote immune responses against oral epithelial dysplasia progression. Cancer Immunology, Immunotherapy. 2025; 74:189.

Bottasso-Arias, N; Mohanakrishnan, M; Trovillion, S; Burra, K; Russell, NX; Wu, Y; Xu, Y; Sinner, D. Wnt5a and Notum influence the temporal dynamics of cartilaginous mesenchymal condensations in developing trachea. Frontiers in Cell and Developmental Biology. 2025; 13:1523833.

Kim, H; Yi, S; Liyanage, P; Zhao, S; Wikenheiser-Brokamp, KA; McMillin, L; Xu, Y; Kitzmiller, JA; Whitsett, JA; Naren, AP; Mun, KS. Development of a 3D bioengineered human lung submucosal gland ductal airway model to study mucociliary clearance in vitro. 2025; 1:100013.

McMillan, A; Hoffman, MR; Xu, Y; Wu, Z; Thayer, E; Peel, A; Guymon, A; Kanotra, S; Salem, AK. 3D bioprinted ferret mesenchymal stem cell-laden cartilage grafts for laryngotracheal reconstruction in a ferret surgical model. Biomaterials Science. 2025; 13:1304-1322.

Rataan, AO; Xu, Y; Geary, SM; Zakharia, Y; Kamel, ES; Rustum, YM; Salem, AK. Targeting transforming growth factor-β1 by methylseleninic acid/seleno-L-methionine in clear cell renal cell carcinoma: Mechanisms and therapeutic potential. Cancer Treatment and Research Communications. 2025; 42:100864.

He, H; Bell, SM; Davis, AK; Zhao, S; Sridharan, A; Na, CL; Guo, M; Xu, Y; Snowball, J; Swarr, DT; Zacharias, WJ; Whitsett, JA. PRDM3/16 regulate chromatin accessibility required for NKX2-1 mediated alveolar epithelial differentiation and function. Nature Communications. 2024; 15:8112.

Deng, R; Tian, R; Li, X; Xu, Y; Li, Y; Wang, X; Li, H; Wang, L; Xu, B; Yang, D; Tang, S; Xue, B; Zuo, C; Zhu, H. ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/β-catenin/PD-L1 axis. iScience. 2024; 27:109533.

Bhattacharya, S; Myers, JA; Baker, C; Guo, M; Danopoulos, S; Myers, JR; Bandyopadhyay, G; Romas, ST; Huyck, HL; Misra, RS; Whitsett, JA; Xu, Y; Pryhuber, GS; Mariani, TJ. Single-Cell Transcriptomic Profiling Identifies Molecular Phenotypes of Newborn Human Lung Cells. Genes. 2024; 15:298.

Deng, R; Zhang, L; Chen, S; Li, X; Xue, B; Li, H; Xu, Y; Tian, R; Liu, Q; Wang, L; Liu, S; Yang, D; Li, P; Tang, S; Zhu, H. PZR suppresses innate immune response to RNA viral infection by inhibiting MAVS activation in interferon signaling mediated by RIG-I and MDA5. Antiviral Research. 2024; 222:105797.

Gaddis, N; Fortriede, J; Guo, M; Bardes, EE; Kouril, M; Tabar, S; Burns, K; Ardini-Poleske, ME; Loos, S; Schnell, D; Xu, Y; Tickle, T; Aronow, BJ; Salomonis, N. LungMAP Portal Ecosystem: Systems-level Exploration of the Lung. American Journal of Respiratory Cell and Molecular Biology. 2024; 70:129-139.

Hu, Q; Chen, S; Deng, R; Deng, H; Peng, M; Wang, X; Deng, S; Wang, J; Xu, B; Xu, Y; Zhu, H; Zheng, J; Xia, M; Zuo, C. Exosomal PDL1 Suppresses the Anticancer Activity of CD8+ T Cells in Hepatocellular Carcinoma. Editor, Botelho MC. Cellular oncology (Dordrecht). 2024; 2024:1608582.

Guo, M; Morley, MP; Jiang, C; Wu, Y; Li, G; Du, Y; Zhao, S; Wagner, A; Cakar, AC; Kouril, M; Morrisey, EE; Whitsett, JA; Lin, S; Xu, Y. Guided construction of single cell reference for human and mouse lung. Nature Communications. 2023; 14:4566.

Zhang, Z; Zhou, J; Ni, P; Hu, B; Jolicoeur, N; Deng, S; Xiao, Q; He, Q; Li, G; Xia, Y; Zhang, B; Cai, K; Xu, Y; Liu, B. PF-D-Trimer, a protective SARS-CoV-2 subunit vaccine: immunogenicity and application. npj Vaccines. 2023; 8:38.

Uehara, Y; Tanaka, Y; Zhao, S; Nikolaidis, NM; Pitstick, LB; Wu, H; Yu, JJ; Zhang, E; Hasegawa, Y; Noel, JG; Inoue, Y; Altinişik, G; Xu, Y; McCormack, FX. Insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis. Nature Communications. 2023; 14:1205.

Bian, F; Lan, YW; Zhao, S; Deng, Z; Shukla, S; Acharya, A; Donovan, J; Le, T; Milewski, D; Bacchetta, M; Xu, Y; Shi, D; Kalinichenko, VV; Kalin, TV. Lung endothelial cells regulate pulmonary fibrosis through FOXF1/R-Ras signaling. Nature Communications. 2023; 14:2560.

Guo, M; Wikenheiser-Brokamp, KA; Kitzmiller, JA; Jiang, C; Wang, G; Wang, A; Preissl, S; Hou, X; Buchanan, J; Karolak, JA; Stankiewicz, P; Kalinichenko, VV; Wambach, JA; Whitsett, JA. Single Cell Multiomics Identifies Cells and Genetic Networks Underlying Alveolar Capillary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2023; 208:709-725.

Lesnak, JB; Nakhla, DS; Plumb, AN; Mcmillan, A; Saha, S; Gupta, N; Xu, Y; Phruttiwanichakun, P; Rasmussen, L; Meyerholz, DK; Salem, AK; Sluka, KA. Selective androgen receptor modulator microparticle formulation reverses muscle hyperalgesia in a mouse model of widespread muscle pain. PAIN. 2023; 164:1512-1523.

Li, H; Liu, S; Feng, Q; Deng, R; Wang, J; Wang, X; Tian, R; Xu, Y; Chen, S; Liu, Q; Peng, Y; Tang, S; Xue, B; Zhu, H. Regulation of PKR-dependent RNA translation inhibition by TRIM21 upon virus infection or other stress. Editor, Yount JS. PLoS Pathogens. 2023; 19:e1011443.

Minor, BM N; LeMoine, D; Seger, C; Gibbons, E; Koudouovoh, J; Taya, M; Kurtz, D; Xu, Y; Hammes, SR. Estradiol Augments Tumor-Induced Neutrophil Production to Promote Tumor Cell Actions in Lymphangioleiomyomatosis Models. Endocrinology. 2023; 164:bqad061.

Sikkema, L; Ramírez-Suástegui, C; Strobl, DC; Gillett, TE; Zappia, L; Madissoon, E; Markov, NS; Zaragosi, LE; Ji, Y; Ansari, M; Misharin, AV; Nawijn, MC; Luecken, MD; Theis, FJ. An integrated cell atlas of the lung in health and disease. Nature Medicine. 2023; 29:1563-1577.

Olatoke, T; Wagner, A; Astrinidis, A; Zhang, EY; Guo, M; Zhang, AG; Mattam, U; Kopras, EJ; Gupta, N; Smith, EP; Whitsett, JA; McCormack, FX; Xu, Y; Yu, JJ. Single-cell multiomic analysis identifies a HOX-PBX gene network regulating the survival of lymphangioleiomyomatosis cells. Science Advances. 2023; 9:eadf8549.

Astrinidis, A; Li, C; Zhang, EY; Zhao, X; Zhao, S; Guo, M; Olatoke, T; Mattam, U; Huang, R; Zhang, AG; Setchell, KD R; McCormack, FX; Xu, Y; Yu, JJ. Upregulation of acid ceramidase contributes to tumor progression in tuberous sclerosis complex. JCI insight. 2023; 8:e166850.

Hudock, KM; Collins, MS; Imbrogno, MA; Kramer, EL; Brewington, JJ; Ziady, A; Zhang, N; Snowball, J; Xu, Y; Carey, BC; Gollomp, K; Mangalmurti, N; Trapnell, BC; Clancy, JP. Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function. Frontiers in Immunology. 2023; 13:1023553.

Du, Y; Guo, M; Wu, Y; Wagner, A; Perl, AK; Wikenheiser-Brokamp, K; Yu, J; Gupta, N; Kopras, E; Krymskaya, V; Kwiatkowski, D; Henske, EP; McCormack, F; Xu, Y. Lymphangioleiomyomatosis (LAM) Cell Atlas. Thorax. 2023; 78:85-87.

Xue, B; Li, H; Liu, S; Feng, Q; Xu, Y; Deng, R; Chen, S; Wang, J; Li, X; Wan, M; Tang, S; Zhu, H. The redox cycling of STAT2 maintains innate immune homeostasis. Cell Reports. 2022; 40:111215.

Stevens, J; Steinmeyer, S; Bonfield, M; Peterson, L; Wang, T; Gray, J; Lewkowich, I; Xu, Y; Du, Y; Guo, M; Miller, L; Chougnet, C; O’Connor, DH; Deshmukh, H. The balance between protective and pathogenic immune responses to pneumonia in the neonatal lung is enforced by gut microbiota. Science Translational Medicine. 2022; 14:eabl3981.

Xu, Y; Yang, Q; Xue, B; Wang, X; Tian, R; Deng, R; Chen, S; Wang, X; Wang, L; Wang, C; Liu, S; Yang, D; Tang, S; Zhu, H. Heat Shock-Binding Protein 21 Regulates the Innate Immune Response to Viral Infection. Editor, Williams BRG. Journal of Virology. 2022; 96:e0000122.

Toth, A; Steinmeyer, S; Kannan, P; Gray, J; Jackson, CM; Mukherjee, S; Demmert, M; Sheak, JR; Benson, D; Kitzmiller, J; Chougnet, CA; Jobe, AH; Deshmukh, H; Zacharias, WJ. Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates. Science Translational Medicine. 2022; 14:eabl8574.

Chen, S; Liu, Q; Zhang, L; Ma, J; Xue, B; Li, H; Deng, R; Guo, M; Xu, Y; Tian, R; Li, X; Liu, S; Yang, D; Zhu, H. The Role of REC8 in the Innate Immune Response to Viral Infection. Editor, Williams BRG. Journal of Virology. 2022; 96:e0217521.

Han, B; Li, X; Ai, RS; Deng, SY; Ye, ZQ; Deng, X; Ma, W; Xiao, S; Wang, JZ; Wang, LM; Xie, C; Zhang, Y; Xu, Y; Zhang, Y. Atmospheric particulate matter aggravates cns demyelination through involvement of TLR-4/NF-kB signaling and microglial activation. eLife. 2022; 11:e72247.

Bottasso-Arias, N; Leesman, L; Burra, K; Snowball, J; Shah, R; Mohanakrishnan, M; Xu, Y; Sinner, D. BMP4 and Wnt signaling interact to promote mouse tracheal mesenchyme morphogenesis. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2022; 322:L224-L242.

Sun, X; Perl, AK; Li, R; Bell, SM; Sajti, E; Kalinichenko, VV; Kalin, TV; Misra, RS; Deshmukh, H; Clair, G; Xu, Y; Pryhuber, G; Whitsett, J; Morrisey, EE. A census of the lung: CellCards from LungMAP. Developmental Cell. 2022; 57:112-145.e2.

Gokey, JJ; Snowball, J; Sridharan, A; Sudha, P; Kitzmiller, JA; Xu, Y; Whitsett, JA. YAP regulates alveolar epithelial cell differentiation and AGER via NFIB/KLF5/NKX2-1. iScience. 2021; 24:102967.

Wang, G; Wen, B; Ren, X; Li, E; Zhang, Y; Guo, M; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Generation of Pulmonary Endothelial Progenitor Cells for Cell-based Therapy Using Interspecies Mouse-Rat Chimeras. American Journal of Respiratory and Critical Care Medicine. 2021; 204:326-338.

Sitaraman, S; Martin, EP; Na, CL; Zhao, S; Green, J; Deshmukh, H; Perl, AK T; Bridges, JP; Xu, Y; Weaver, TE. Surfactant protein C mutation links postnatal type 2 cell dysfunction to adult disease. JCI insight. 2021; 6:e142501.

Zhu, H; Wang, X; Xu, Y; Tian, R; Deng, R; Wang, J; Chen, S; Li, H. HBP21 Inhibiting Insulin-induced PI3K/AKT Signal Pathway Mechanism. Hunan Daxue Xuebao/Journal of Hunan University Natural Sciences. 2021; 48:141-148.

Gokey, JJ; Snowball, J; Green, J; Waltamath, M; Spinney, JJ; Black, KE; Hariri, LP; Xu, Y; Perl, AK. Pretreatment of aged mice with retinoic acid supports alveolar regeneration via upregulation of reciprocal PDGFA signalling. Thorax. 2021; 76:456-467.

Milewski, D; Shukla, S; Gryder, BE; Pradhan, A; Donovan, J; Sudha, P; Vallabh, S; Pyros, A; Xu, Y; Barski, A; Millay, DP; Khan, J; Kalinichenko, VV; Kalin, TV. FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma. Oncogene: Including Oncogene Reviews. 2021; 40:2182-2199.

Muus, C; Luecken, MD; Eraslan, G; Sikkema, L; Waghray, A; Heimberg, G; Kobayashi, Y; Vaishnav, ED; Subramanian, A; Smillie, C; Smith, NP; Sountoulidis, A; Strunz, M; Sullivan, TB. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nature Medicine. 2021; 27:546-559.

Wen, B; Li, E; Ustiyan, V; Wang, G; Guo, M; Na, CL; Kalin, GT; Galvan, V; Xu, Y; Weaver, TE; Kalin, TV; Whitsett, JA; Kalinichenko, VV. In Vivo Generation of Lung and Thyroid Tissues from Embryonic Stem Cells Using Blastocyst Complementation. American Journal of Respiratory and Critical Care Medicine. 2021; 203:471-483.

Du, Y; Ouyang, W; Kitzmiller, JA; Guo, M; Zhao, S; Whitsett, JA; Xu, Y. Lung Gene Expression Analysis Web Portal Version 3: Lung-at-a-Glance. American Journal of Respiratory Cell and Molecular Biology. 2021; 64:146-149.