Improving Strategies for Diagnosis, Treatment and Prevention of Craniofacial Birth Defects

The Lan Lab investigates the genetic basis and developmental mechanisms of congenital craniofacial disorders using mutant and/or genome-edited mouse models. We combine in vivo functional studies with cutting-edge multi-omics approaches, including single-cell RNA-seq and genome-wide regulatory element identification, to delineate the gene regulatory networks controlling craniofacial morphogenesis. These studies provide the necessary knowledge to improve strategies for the diagnosis, treatment and/or prevention of craniofacial birth defects.