Aronow Lab

Current Projects

Name: PolyDoms

Purpose: Integrates the results of multiple algorithmic procedures and functional criteria applied to the entire Entrez dbSNP dataset. PolyDoms provides a means to derive a list of candidate SNPs to be evaluated in experimental or epidemiological studies for impact on protein functions and disease risk associations.

Name: ToppGene Suite

Purpose: A one-stop portal for (i) gene list functional enrichment,  (ii) candidate gene prioritization using either functional annotations or network analysis and (iii) identification and prioritization of novel disease candidate genes in the interactome.

Access: toppgene.cchmc.org

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Name: ToppCluster

Purpose: Web server that leverages a powerful enrichment analysis and underlying data environment for comparative analyses of multiple gene lists. ToppCluster’s functionalities enable the identification of specialized biological functions and regulatory networks and systems biology-based dissection of biological states

Access: toppcluster.cchmc.org

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Name: PhenoHM

Purpose: Human-mouse comparative phenome-genome server that facilitates cross-species identification of genes associated with orthologous phenotypes. By cross-mapping mouse-human phenotype terms, extracting implicated genes and extrapolating phenotype-gene associations between species, PhenoHM enables rapid identification of genes that trigger similar outcomes in human and mouse.

Name: GATACA

Purpose:  GATACA or Gene(tic) Associations To Anatomy and Clinical Abnormalities is a disease-centered knowledgebase that enables biomedical researchers to explore, analyze and hypothesize genetic pathways, networks and processes responsible for disease.

Access: gataca.cchmc.org

Status: Ongoing