Shari Wade, PhD

Culminating nearly 20 years of federally-funded research investigating the efficacy of family problem-solving therapy (F-PST) in improving behavioral and family outcomes following pediatric traumatic brain injury (TBI), Shari Wade, PhD, completed individual participant data meta analyses of the results of five clinical trials involving 359 participants that shed light on the optimal timing for delivery of F-PST and the characteristics of children and families who are most likely to benefit. At the same time, she received funding from the Cincinnati Children's innovations program and the Ohio Third Frontier program to create a commercially marketable version of the Teen Online Problem Solving (TOPS). TOPS will be the first evidence-based, commercially available telehealth program for pediatric TBI.

Nathan Evanson, MD, PhD

Changes in brain metabolism are thought to underlie at least some of the deficits seen after traumatic brain injury, including concussion. However, it is not well understood how brain metabolism changes in the long term after brain injury. In work published in Molecular Neurobiology, Nathan Evanson, MD, PhD, and collaborators found that there is widespread metabolic dysfunction in multiple brain regions two months after injury in a rat model of traumatic brain injury. These findings suggest that changes in energy metabolism and excitatory neurotransmission persist for long periods after injury.