Internal Funding
Academic and Research Committee (ARC) Awards
These grants support multi-disciplinary programs that can become self-sustaining within one to three years. Awardees this year are:
| Topic | PI | Division | Title |
| Clinical | Mary Greiner, MD | General Pediatrics | Integrated Data Environment for Children in Foster Care |
| Clinical | Gruschen Veldtman, FRCP, MBChB | Cardiology | Fontan Center |
| Clinical/Research | Hermine Brunner, MD, MSc, MBA and John Harley, MD, PhD | Rheumatology and CAGE | Lupus Treatment and Research Center |
| Research | Burns Blaxall, PhD, FAHA | Molecular Cardiovascular Biology | Center for Translational Fibrosis Research |
| Research | David Haslam, MD | Infectious Diseases | Precision Metagenomics for Infection Risk |
| Research | Stephen Waggoner, PhD | CAGE | Kawasaki Disease—Diagnosis and Treatment |
| Research | James Wells, PhD and Yi Zheng, PhD | Experimental Hematology | Proton Radiation Biology Discovery and Translation |
Center for Clinical and Translational Science and Training (CCTST) Program Awards
Cincinnati Children’s partners with the University of Cincinnati and other institutions to support programs funded through the Center for Clinical and Translational Science and Training (CCTST). This list shows faculty who received grants to support translational research, build core capabilities, develop innovative research methods, or collaborate with community partners.
| Type | Title | PI | PI Department/Division | Co-I | Co-I Department/Division |
| P1 | Natural killer cells in cytomegalovirus vaccination | Stephen Waggoner, PhD | Center for Autoimmune Genomics & Etiology | David Bernstein, MD, MA | Infectious Diseases |
| P1 | Small Animal testing of IV probenecid | Jack Rubinstein | Neurology | ||
| P1 | Development of a Lead Compound Active Against AMP Kinase to Gilioblastoma | Biplab Dasgupta, MD, MPH | Oncology | William Seibel, PhD | Hematology/ Cancer Biology |
| P1 | HIFs Promote Innate Immunity in Histoplasmosis | George Deepe, MD | Infectious Diseases | Claire Chougnet, PhD | Immunobiology |
| P1 | Prevention of red cell storage damage by a combinatorial approach | Francis McCormack | Pulmonary Medicine | ||
| P1 | Correction of Epidermolysis Bullosa Via Genome Editing and Tissue Engineering | John Van Aalst, MD, MS | Craniofacial and Plastic Surgery | Dorothy Supp | Surgery |
| Core | Establishment of a research bronchoscopy core | Dennis McGraw | Pulmonary Medicine | ||
| PI M | Gene/PMTtherapy of hPAP;critical barriers to human translation | Paritha Arumugam, PhD | Translational Pulmonary Science Center | Bruce Trapnell, MD | Pulmonary |
| PI M | The role of ErbB3 | Joan Garrett | College of Pharmacy | Pulmonary Medicine | |
| RT Core | Hyperpolarized-gas core: Lighting up the lungs | Jason Woods, PhD | Pulmonary Medicine | Zackary Cleveland, PhD | Pulmonary Medicine |
| RT Core | Epigenomics Data Analysis Core | Artem Barski, PhD | Allergy and Immunology and Human Genetics | ||
| JIT C1 | 3D chemotaxis of T lymphocytes from head and neck cancer patients | Laura Conforti | Nephrology and Hypertension | Steve Woodle | Transplant Surgery |
| JIT C1 | Cell RNAseq Analysis of Human Plasma Cells | James Driscoll | Hematology and Oncology | Jennifer McGuire | Psychology and Behavioral Science |
| JIT C1 | Glutamate, glutamine, and GABA in chronic brain injury | Nathan Evanson, MD, PhD | Pediatric Rehab. Medicine | ||
| JIT C1 | Development of a novel systematic high- throughput targeted metagenomics technology | Long (Jason) Lu, PhD | Biomedical Informatics | ||
| JIT C1 | Therapeutic Benefit of HSP90 Inhibition in Pulmonary Fibrosis | Satish Madala, PhD | Pulmonary Medicine | Joshua Benoit | Biological Sciences, Arts & Sciences |
| JIT C1 | Determining Mechanisms Associated with Dispersal | Stephen Matter | Biological Sciences, Arts & Sciences | ||
| JIT C2 | Prostaglandin biosynthesis: a novel therapeutic target in TSC disorders | Jane Yu | Internal Medicine, Pulmonary | Jerry Lingrel | Molecular Genetics |
| JIT C2 | Role of Na,K-ATPase isoform in skeletal muscle regeneration and differentiation | Judith Heiny | Molecular and Cellular Physiology | ||
| JIT C2 | Virus-mediated cell-specific inhibition of miR- 324-5p in epilepsy | Christina Gross, PhD | Neurology | ||
| JIT C2 | Identification of Cancer-associated Fibroblasts-induced Melanoma Suppression | Yuhang Zhang | Division of Pharmaceutical Science | ||
| JIT C2 | Genetic Differences in Abdominal Aortic Thrombi | Phillip Owens | Internal Medicine, Cardiovascular Health and Disease | Simon Hogan, PhD | Allergy and Immunology |
| JIT C3 | How does the UPR promote allergenicity? | Fred D. Finkelman, MD | Allergy Immunology, and Rheumatology | ||
| JIT C3 | RhoA in immune aspects of colitis | Fukun Guo, PhD | Experimental Hematology and Cancer Biology | ||
| JIT C3 | Metabolic Targets in Myelodysplastic Syndromes | Gang Huang, PhD | Pathology and Experimental Hematology and Cancer Biology | ||
| JIT C3 | B Cell Epigenetic Dysregulation & Type 1 Kabuki Syndrome | Andrew W. Lindsley, MD, PhD | Allergy and Immunology | Joan Garrett | Pharmaceutical Sciences |
| JIT C3 | Determining Changes to Mitochondrial Proteins in Response to Drug Resistance | Edward Merino | Arts and Sciences: Chemistry | ||
| P&M C1 | Design Thinking to Improve Informed Consent in the ED | Todd Florin, MD, MSCE | Emergency Medicine | ||
| P&M C1 | An Informed Consent Algorithm to Guide Acute Care Research | Cheryl McCullumsmith | Psychiatry and Behavioral Neuroscience | Jacqueline Grupp-Phelan, MD, MPH-ED | Emergency Medicine |
| P&M C1 | iPad App-Based Consent to Improve Study Comprehension and Information Retention | David Russell, MD, PhD | Neonatology and Pulmonary Biology | Brenda Poindexter, MD, MS | Neonatology and Pulmonary Biology |
| P&M C3 | Validating a Geocoding Approach for Multi Site Studies | Cole Brokamp, PhD | Biostatistics and Epidemiology | Patrick Ryan, PhD, MS | Biostatistics and Epidemiology |
| P&M C3 | Cryptic to Concrete: A Framework to Improve Accuracy of Burn Scar Assessment | Elizabeth Dale | Plastic/Burn Surgery | ||
| P&M C3 | AdmixPower: Power and sample size calculators for admixture mapping in admixed populations | Tesfaye Mersha, PhD | Asthma Research | Mekibib Altaye, PhD | Biostatistics and Epidemiology |
| P&M C3 | Optimization of Early Phase Clinical Trial Enrollment Using a Bayesian Approach | Simon Tremblay | Transplant Surgery | Steve Woodle | Transplant Surgery |
| P&M C3 | Machine learning method to facilitate nutritional therapy metabolomics studies | Xueheng Zhao, PhD | Mass Spectrometry Laboratory | Kenneth Setchell, PhD | Mass Spectrometry Laboratory |
| Retreats, Workshops & Symposiums | 2017 Research Week | Christopher Lindsell | Emergency Medicine | ||
| Retreats, Workshops & Symposiums | BD2K-LINCS Data Science Symposium | Mario Medvedovic, PhD | Environmental Health | ||
| Retreats, Workshops & Symposiums | 2nd Annual Conference to Eliminate Racial Disparities in Breastfeeding and Infant Mortality: Building Bridges Toward Equity. | Julie Ware, MD, MPH, IBCLC | General & Community Pediatrics | ||
| Retreats, Workshops & Symposiums | Cincinnati Children's Hospital Medical Center and University of Cincinnati Symposium: Human organoid models to study enteric pathogenesis | James Wells, PhD | Developmental Biology | ||
| Retreats, Workshops & Symposiums | Precision Genomics Midwest | Peter White, PhD | Biomedical Informatics | ||
| Retreats, Workshops & Symposiums | Smith-Lemli-Opitz Scientific Conference | Laura Woollett | Pathology and Laboratory Medicine | ||
| Community Health Grant | Be Well Sport Club: Collaboration for Welness in Children with Physical Disability | Jennifer Angeli, PT, DPT, PhD | Occupational Therapy & Physical Therapy | Adam Ayers | |
| Community Health Grant | Healthy Student Bodies for Healthier Communities | Deborah Mariner Allsop | Donna Shambley-Ebron | College of Nursing | |
| Community Health Grant | FOsTering Sports Ream Participation (FOoTSTEP) | Mary Greiner, MD | General & Community Pediatrics | Brandy Pendelton | |
| Community Health Grant | Neighbors Helping Neighbors: Preventive and Behavioral Health | Russell Curington | College of Pharmacy | ||
| Community Health Grant | Improving Family Health through Fit Kit Intervention | Jenna Williams, MS, RD | Healthworks | Robert Siegel, MD, FAAP | Center for Better Health and Nutrition |
| Partnership Development Grant | Recreational Music Making: Impact on Stress Level and Well-Being in African American Women | Sheila Nared | Melinda Butsch Kovacic, MPH, PhD | Asthma Research | |
| Partnership Development Grant | Pilot Testing of an integrative chronic pain group visit for homeless adults with chronic pain | Nancy Elder | Family Medicine | Kate Bennett | |
| Partnership Development Grant | Parents and Family Members: Leaders of Care for Childhood Asthma Management. | Ginny Frazier | Camille Graham, MD | General & Community Pediatrics | |
| Partnership Development Grant | Student-Run Free Clinic Cincinnati | Caroline Hensley | Martita Meehan, Dawna-Cricket | ||
| Partnership Development Grant | Exploring the Efficacy of a Resource Map for Persons Experiencing Homelessness and the Agencies that Serve Them | Joseph Kiesler | Family Medicine | Francie Wolgen |
Center for Pediatric Genomics Pilot Studies
The Center for Pediatric Genomics (CpG) has established a fund to distribute $1 million annually among projects that accelerate innovative research, development, and implementation of genomic science. Awardees this year are:
| Faculty | Division | Title |
| Iouri Chepelev, PhD | Center for Autoimmune Genomics and Etiology | Altered Three-Dimensional Chromatin Structure of the MHC Region in Lupas |
| Theodosia Kalfa, MD, PhD | CBDI/Hematology | Congenital Dyserythropoietic Anemia Registry (CDAR) |
| Laura Ramsey, PhD | Research in Patient Services | Genetic Influences on Efficacy of Methotrexate in a Murine Model of Arthritis |
| Beena Kamath-Rayne, MD, MPH | PI/Neonatology and Pulmonary Biology | Novel Biomarkers to Predict Fetal Maturity from Amniotic Fluid Transcriptome |
| Michael Jordan, MD | Immunobiology | N-CoR, Lymphoid Development and Severe Combined Immune Deficiency |
| Hector Wong, MD | Critical Care Medicine | Deconvolution of Neutrophil Heterogeneity in Pediatric Sepsis |
| Jonathan Katz, PhD | Immunobiology | Type 1 Diabetes Etiology as Revealed by Shared Molecular Mechanisms |
| Kakajan Komurov, PhD | CBDI/Exp Hem | A Web Portal for Query and Building of Structural Models of Disease Mechanisms |
| Sing Sing Way, MD, PhD | Infectious Diseases | Gene Expression Among Individual Microchimeric Maternal Cells |
Children’s Health Research Career Development Award (CHRCDA)
This NICHD-funded program provides grants to support training physician-scientists to stimulate pediatric research across a variety of disciplines. This year’s awardees are:
| Name | Division | Title of Research |
| Matthew Alder, MD, PhD | CBDI - BMT and Immune Deficiency | A Potential Role for olfm4 in Sepsis |
| Kathryn Weaver, MD | Human Genetics | Ttc21b Is Critical for Craniofacial Development |
Cincinnati Children's Innovation Fund
The Cincinnati Children’s Innovation Fund is designed to accelerate the commercialization of discoveries, innovations, projects or products. Recipients this year are:
| PI | Title |
| Hector Wong, MD | Rapid Biomarker Assay for Septic Shock Mortality Risk Stratification |
| Bruce Trapnell, MD, MS | A Pilot Study of Pioglitazone Therapy of Autoimmune Pulmonary Alveolar Proteinosis |
| Doug Millay, PhD | Harnessing Cell Fusion to Deliver Therapeutic Material to Skeletal Muscle |
| Yizhao Ni, PhD | Automated Patient Identification for Research Studies in Emergency Departments |
| Stuart Goldstein, MD, FAAP, FNKF | Development of Electronic Health Record Diagnostic Service to Identify and Direct Biomarker Assessment in Critically Ill Children at Risk for Acute Kidney Injury |
| Abby Hess, DNP, APRN, FNP-BC | Development of a Game Application that Interfaces with Anesthesia Equipment to Facilitate Improved Anesthesia Induction Experiences and Post-Operative Outcomes in Pediatric Patients |
Adare Drug Repurposing and Optimization Innovation Fund
This fund focuses on research to help medications initially developed for adults better meet the needs of children. As in past years, Adare Pharmaceuticals has selected a recipient for the Adare Drug Repurposing and Optimization Innovation Award.
Fifth Third Bank/Charlotte R. Schmidlapp Women Scholars Awards
This program provides grants to support the academic career development of women faculty who have demonstrated academic potential and leadership skills as they progress toward the ranks of associate and full professor. This year’s awardees are:
| Name | Division | Year |
| Patricia Fulkerson, MD PhD | Allergy and Immunology | 2016-2017 |
| Ellen Lipstein, MD, MPH | Adolescent and Transition Medicine | 2016-2017 |
| Teodosia Kalfa, MD, PhD | Hematology | 2017-2018 |
GAP Funding Awards
This program provides one year of support to bridge gaps in R01-level funding or equivalent. Awardees this year are:
| PI | Division | Grant Title | Funding Round |
| Alexei Grom, MD | Rheumatology | Clinical significance of genetic variation in the cyolytic pathway in MAS/sHLH | 2016 - July |
| Susmita Kashikar-Zuck, PhD | BMCP | Multi-site randomized clinical trial of FIT Teens for Juvenile Fibromyalgia | 2016 - July |
| Qishen Pang, PhD | CBDI/Exp Hem | FA DDR Pathway in Germline Integrity | 2016 - July |
| Joshua Waxman, PhD | HI/Molecular Cardio Biol | Mechanisms restricting outflow tract development | 2016 - July |
| Timothy Weaver, MS, PhD | PI/Pulmonary Biology | Deficiency of Phospholipid transfer protein, a driver of allergic airway disease | 2016 - July |
| Yi Zheng, PhD | CBDI/Exp Hem | Leukemia stem cell polarity and differentiation therapy | 2016 - July |
| Biplap DasGupta, PhD | CBDI/Oncology | Exploring Therapeutic Vulnerability of Passenger Alterations in Glioblastoma | 2016 - November |
| Matthew Flick, PhD | CBDI/Hematology | Thrombin-dependent mechanisms of pancreatic ductal adenocarcinoma disease | 2016 - November |
| Richard Lang, PhD | Ophthalmology | Regulation of eye development by an Opsin5-dopamine pathway | 2016 - November |
| Susanne Wells, PhD | CBDI/Oncology | HPV infection and replication: role of the FA pathway | 2016 - November |
| Eric Mullins, MD | CBDI/Hematology | Mechanisms linking hemostatic factors and neru | 2017 - March |
| Yutaka Yoshida, PhD | Developmental Biology | Formation and function of corticospinal circuits | 2017 - March |
| Andy Herr, PhD | Immunobiology | Studies of metal-dependent intercellular adhesion in staphylococcal biofilms | 2017 - March |
Place Outcome Awards
This program, administered by the James M. Anderson Center for Health Systems Excellence, provides grants to stimulate the development of health services and quality improvement research at Cincinnati Children’s and to ensure optimal implementation of clinical and operational innovations in the care delivery system. Awardees receiving funding are:
| Project Period | |||||
| PI Name | Division Name | CO PI Name | Award Start Date | Award End Date | Award Title |
| Rachel M. Thienprayoon, MD, MSCS | Anesthesia | 1/1/2017 | 12/30/2018 | Identifying and Defining Caregiver and Provider-Prioritized Domains of Quality in Pediatric Hospice/Palliative Care | |
| David Hartley, PhD, MPH | James M Anderson Center/ Emergency Med. | Nathn Timm, MD | 7/1/2016 | 6/30/2018 | Social Media for Early Warning of Epidemics |
| Amanda Schondelmeyer, MD, MSc | Hospital Medicine | 7/1/2016 | 6/30/2018 | Understanding Continuous Physiologic Monitoring in Hospitalized Patients: A Mixed Methods Study |
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| Karen Burkett, PhD, RN PPCNP-BC, | Developmental & Behavioral Pediatrics | 7/1/2016 | 6/30/2017 | Headstart Navigator Intervention for Development Testing | |
| Kristen Copeland, MD | General & Community Pediatrics | 7/1/2015 | 6/30/2017 | Innovations in Management of Obesity and Inactivity in Pediatric Primary Care | |
| Natoshia Cunningham, PhD | Developmental & Behavioral Pediatrics | 7/1/2015 | 6/30/2017 | Improving Screening and Care for Anxious Youth with Functional Abdominal Pain | |
| Chris Dandoy, MD, MSc | CBDI/Bone Marrow Transplantation & Immune Deficiency | 7/1/2015 | 6/30/2017 | Factorial design to improve sleep hygiene in patients and families undergoing stem cell transplant | |
| Mark Paterno, PT, PhD, MBA, SCS | Occupational Therapy and Physical Therapy and Sports Medicine | 7/1/2015 | 6/30/2017 | Redefining Rehabilitation after Anterior Cruciate Ligament Reconstruction |
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| Thomas Sitzman, MD | Plastic Surgery | 7/1/2015 | 6/30/2017 | Standardizing Assessment and Improving Outcomes in Cleft Palate Surgery |
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| Kathleen Walsh, MD, MSc | James M Anderson Center / Behavioral Medicine & Psychology | Lori Crosby, PsyD | 7/1/2015 | 6/30/2017 | A multifaceted intervention to improve adherence to hydroxyurea among children with sickle cell disease |
Procter Scholar Grant
The Procter Scholar Program supports faculty members from the Departments of Pediatrics, Surgery, Radiology, Patient Services, and Anesthesia who are committed to pursuing academic research careers.
| Year | Recipient | Division | Title |
| Third Year | Ernest Pedapati, MD | Psychiatry | Cortical Plasticity and Neuromodulation of Social Cognition in Autism Spectrum Disorders |
| Third Year | Hitesh Deshmukh, MD, PhD | Neonatology | Developmental Regulation of Host Resistance and Innate Immune Response by Intestinal Microbes |
| Third Year | Patrick McGann, MD | Hematology | A Phase I/II Study of Hydroxyurea for Children with Sickle Cell Anemia in Angola |
| First Year | Theresa Alenghat, VMD, PhD | Immunobiology | Epigenomic regulation of inflammatory Bowel Disease |
| First Year | Grant Schulert, MD, PhD | Rheumatology | Monocyte and macrophage polarization in systemic JIA and MAS |
| First Year | Amy Shah, MD | Endocrinology | The effects of Bariatric surgery on high density lipoprotein subspecies and their function |
| First Year | John Hutton, MD | Gen Peds/Reading and Literacy | Validation of a "Novel" Literacy Screening Tool and th Neurobiology of Rhyming |
| First Year | Pooja Khandelwal, MD | CBDI/BMT | Inhibition of lymphocyte trafficking as novel acute visceral GVHD prophylaxis in pediatrics |
Research, Innovation & Pilot (RIP) Funding Awards
This program provides grants to support collecting preliminary data for innovative and essential projects considered to be good candidates for future external funding. Awardees receiving funding this year include:
| PI | Division | Grant Title | Funding Round |
| Scott Powers, PhD, ABPP | BMCP | Discovery mechanisms of cognitive behavioral therapy response in youth with migraine | 2016 - July |
| Jason Woods, PhD | Pulmonary/IRC | Detecting early BOS in bone-marrow transplant recipients | 2016 - July |
| Fred Finkelman, MD | Immunobiology | Role of the unfolded protein response in Allergy Pathogenesis | 2016 - November |
| John Hogenesch, PhD | Chronobiology Center | Molecular mechanisms that connect circadian rhythms and cell cycle in gastrointestinal system | 2016 - November |
| Takahisa Nakamura, PhD | Endocrinology | Identification of endogenous pathogenic dsRNAs that dysregulate metabolic homeostasis in obesity | 2016 - November |
| Dean Beebe, PhD, ABPP | BMCP | Night to Night Sleep Variability as a contributor to adolescent obesogenic behavior | 2016 - November |
| Greg Myer, PhD, FACSM | Sports Medicine | Prospective model of brain plasticity associated with musculoskeletal trauma | 2016 - November |
| Jean Tkach, PhD | IRC | MRI Markers for Pulmonary Hypertension in Neonates with BPD | 2016 - November |
| Marie-Dominique Filippi, PhD | CBDI/Exp Hem | Cytokine signaling in pre-leukemic hematopoietic stem cell emergence and predisposition to leukemia | 2017 - March |
| Brian Gebelein, PhD | Developmental Biology | Molecular defects underlying NEUROG3 mutations associated with human diseases | 2017 - March |
| H. Lee Grimes, PhD | Immunobiology | Elucidation of developmental trajectories of hematopoietic stem cells and their immediate mixed lineage intermediates undergoing specification | 2017 - March |
| Ruhikanta Meetei, PhD | CBDI/Exp Hem | Novel interacting partners of FANCD2 in response to replication stress at newly replicated DNA | 2017 - March |
| Steve Wu, MD | Neurology | Mechanism of Frontal Cortex Mediated Motor Control in Tourette Syndrome | 2017 - March |
| Chunyue Yin, PhD | Gastroenterology | Deficiency in ATP-binding cassette transporter ABCC12 contributes to progressive familial intrahepatic cholestrasis | 2017 - March |
| Shelia Angeles-Han, MD, MSc | Rheumatology | Measuring meaningful biomarkers in children with chronic non-infectious Uveitis | 2017 - March |
Trustee Grant Awards
This program provides research funds for junior faculty to support rapid achievement of independent, sustained extramural funding for their research. This year’s awardees are:
| Award Recipient | Department/Discipline | Title of Trustee Award Project |
| Theresa Alenghat, VMD, PhD | Immunobiology | Regulation of Intestinal Homeostasis by Commensal Bacteria-Derived Metabolites |
| Sarah Beal, PhD | Behavioral Medicine and Clinical Psychology | Understanding Health and Wellbeing Among Adolescents in Protective Custody |
| Katherine Bowers, PhD, MPH | Biostatistics & Epidemiology | Prenatal Maternal Distress and Offspring Neurodevelopment |
| Zackary Cleveland, PhD | Pulmonary Medicine | Tissue Density and Specific Ventilation MRI in Models of Progressive Lung Disease |
| Andrew Dauber, MD | Endocrinology | Functional and Developmental Characterization of Activation Mutations in CDKN1C |
| Patricia Fulkerson, MD, PhD | Allergy and Immunology | Roles of Helios and Aiolos in Eosinophil Development |
| Tzipi Horowitz-Kraus, PhD | General and Community Pediatrics | The Role of Executive Functions in Reading in Children with Dyslexia |
| Darren Kadis, PhD | Neurology | Mapping Language with fMRI-constrained MEG Effective Connectivity Analyses |
| Satish Madala, PhD | Pulmonary Medicine | Wilms' Tumor 1 - Regulation of Pulmonary Fibrosis |
| Yutaka Maeda, DVM, PhD | Pulmonary Biology | Mechanism of NKX2-1-Mediated Suppression of Airway Hyper-Secretion |
| Phillip Minar, MD | Gastroenterology | Molecular Signature to Predict Response to Biologic Therapy in Pediatric Crohn's |
| Jun Nakamura, PhD | Neurosurgery | Molecular characterization of choroid plexus cilia in a novel mouse mutant with communicating hydrocephalus |
| Catherine Quatman-Yates, PT-DPT | Sports Medicine | Autonomic Dysfunction: A Systemic Impairment and Therapeutic Target for Mild Traumatic Brain Injuries |
| Jennifer Schumacher, PhD | Developmental Biology | Roles of the adaptor protein She in Vegf signaling and vascular maintenance |
| Ting Wen, MD, PhD | Allergy and Immunology | Investigating the roles of FFAR3 in Th2 cytokine production by esophageal lymphocytes |
