Experimental Hematology
Publications
Division Publications
Adams AK, Bolanos LC, Dexheimer PJ, Karns RA, Aronow BJ, Komurov K, Jegga AG, Casper KA, Patil YJ, Wilson KM, Starczynowski DT, Wells SI. Irak1 Is a Novel Dek Transcriptional Target and Is Essential for Head and Neck Cancer Cell Survival. Oncotarget . 2015; 6:43395-407.
Adams G, Rosenfeldt L, Frederick M, Miller W, Waltz D, Kombrinck K, McElhinney K, Flick M, Monia B, Revenko A. Colon Cancer Growth and Dissemination Relies Upon Thrombin, Stromal Par-1, and Fibrinogen. Cancer Res . 2015; 75:4235-43.
Agerstam H, Karlsson C, Hansen N, Sandén C, Askmyra M, von Palffy S, Hogberg C, Rissler M, Wunderlich M, Juliusson G, Richter J, Sjöström K, Bhatia R, Mulloy JC, Järås M, Fioretos T. Antibodies Targeting Human Il1rap (Il1r3) Show Therapeutic Effects in Xenograft Models of Acute Myeloid Leukemia. Proc Natl Acad Sci U S A . 2015; 112:10786-91.
Amarachintha S, Sertorio M, Wilson A, Li X, Pang Q. Fanconi Anemia Mesenchymal Stromal Cells-Derived Glycerophospholipids Skew Hematopoietic Stem Cell Differentiation through Toll-Like Receptor Signaling. Stem Cells . 2015; 33:3382-96.
Arumugam PI, Mullins ES, Shanmukhappa SK, Monia BP, Loberg A, Shaw MA, Rizvi T, Wansapura J, Degen JL, Malik P. Genetic Diminution of Circulating Prothrombin Ameliorates Multiorgan Pathologies in Sickle Cell Disease Mice. Blood . 2015; 126:1844-55.
Barry D, Xu K, Meadows S, Zheng Y, Norden P, Davis G, Cleaver O. Cdc42 Is Required for Cytoskeletal Support of Endothelial Cell Adhesion During Blood Vessel Formation in Mice. Development . 2015; 142:3058.
Benito JM, Godfrey L, Kojima K, Hogdal L, Wunderlich M, Geng HM, Marzo I, Harutyunyan KG, Golfman L, North P, Kerry J, Ballabio E, Ni Chonghaile T, Gonzalo O, Qiu YH, Jeremias I, Debose L, O'Brien E, Ma HL, Zhou P, et al. MLL-Rearranged Acute Lymphoblastic Leukemias Activate Bcl-2 through H3k79 Methylation and Are Sensitive to the Bcl-2-Specific Antagonist Abt-199. Cell Rep . 2015; 13:2715-27.
Bick G, Zhang F, Meetei AR, Andreassen PR. Coordination of the Recruitment of the Fancd2 and Palb2 Fanconi Anemia Proteins by an Ubiquitin Signaling Network. Chromosoma . 2016:1-14.
Boscolo E, Limaye N, Huang L, Kang KT, Soblet J, Uebelhoer M, Mendola A, Natynki M, Seront E, Dupont S, Hammer J, Legrand C, Brugnara C, Eklund L, Vikkula M, Bischoff J, Boon LM. Rapamycin Improves Tie2-Mutated Venous Malformation in Murine Model and Human Subjects. J Clin Invest . 2015; 125:3491-504.
Comi AM, Sahin M, Hammill A, Kaplan EH, Juhasz C, North P, Ball KL, Levin AV, Cohen B, Morris J, Lo W, Roach ES, Sturge-Weber Syndrome Research Workshop. Leveraging a Sturge-Weber Gene Discovery: An Agenda for Future Research. Pediatr Neurol . 2016; 58:12-24.
Denkinger MD, Leins H, Schirmbeck R, Florian MC, Geiger H. Hsc Aging and Senescent Immune Remodeling. Trends Immunol . 2015; 36:815-24.
Diao HJ, Low WC, Lu QR, Chew SY. Topographical Effects on Fiber-Mediated MicroRNA Delivery to Control Oligodendroglial Precursor Cells Development. Biomaterials . 2015; 70:105-14.
Dries DR, Zhu Y, Brooks MM, Forero DA, Adachi M, Cenik B, West JM, Han YH, Yu C, Arbella J, Nordin A, Adolfsson R, Del-Favero J, Lu QR, Callaerts P, Birnbaum SG, Yu G. Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior. J Biol Chem . 2016; 291:11647-56.
Du W, Amarachintha S, Erden O, Wilson A, Meetei AR, Andreassen PR, Namekawa SH, Pang Q. Fancb Deficiency Impairs Hematopoietic Stem Cell Function. Sci Rep . 2015; 5:18127.
Du W, Amarachintha S, Wilson AF, Pang Q. Hyper-Active Non-Homologous End Joining Selects for Synthetic Lethality Resistant and Pathological Fanconi Anemia Hematopoietic Stem and Progenitor Cells. Sci Rep . 2016; 6:22167.
Du W, Amarachintha S, Wilson AF, Pang Q. Sco2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem Cells. Stem Cells . 2016; 34:960-71.
Emery B, Lu QR. Transcriptional and Epigenetic Regulation of Oligodendrocyte Development and Myelination in the Central Nervous System. Cold Spring Harb Perspect Biol . 2015; 7:a020461.
Fang J, Starczynowski DT. Genomic Instability Establishes Dependencies on Acquired Gene Regulatory Networks: A Novel Role of P62 in Myeloid Malignancies with Del(5q). Mol Cell Oncol . 2015; 2:e1014219.
Filippi M. Leukocyte Transcellular Diapedesis: Rap1b Is in Control. Tissue Barriers . 2015; 3:e1052185.
Filippi M. Neutrophil Actin Regulation: Mkl1 Is in Control. Blood . 2015; 126:1519-20.
Filippi MD. Mechanism of Diapedesis: Importance of the Transcellular Route. Adv Immunol . 2016; 129:25-53.
Gañán-Gómez I, Wei Y, Starczynowski DT, Colla S, Yang H, Cabrero-Calvo M, Bohannan ZS, Verma A, Steidl U, Garcia-Manero G. Deregulation of Innate Immune and Inflammatory Signaling in Myelodysplastic Syndromes. Leukemia . 2015; 29:1458-69.
Geiger H. Depleting Senescent Cells to Combat Aging. Nat Med . 2016; 22:23-4.
Stem Cell Aging: Mechanisms, Consequences, Rejuvenation . Vienna:Springer.
Gentner B, Pochert N, Rouhi A, Boccalatte F, Plati T, Berg T, Sun SM, Mah SM, Mirkovic-Hösle M, Ruschmann J, Muranyi A, Leierseder S, Argiropoulos B, Starczynowski DT, Karsan A, Heuser M, Hogge D, Camargo FD, Engelhardt S, Dohner H, et al. MicroRNA-223 Dose Levels Fine Tune Proliferation and Differentiation in Human Cord Blood Progenitors and Acute Myeloid Leukemia. Exp Hematol . 2015; 43:858-68 e7.
Glait-Santar C, Desmond R, Feng X, Bat T, Chen J, Heuston E, Mizukawa B, Mulloy J, Bodine D, Larochelle A. Functional Niche Competition between Normal Hematopoietic Stem and Progenitor Cells and Myeloid Leukemia Cells. Stem Cells . 2015; 33:3635-42.
Gonsalves C, Li C, Malik P, Tahara S, Kalra V. Peroxisome Proliferator-Activated Receptor-?-Mediated Transcription of Mir-301a and Mir-454 and Their Host Gene Ska2 Regulates Endothelin-1 and Pai-1 Expression in Sickle Cell Disease. pmc/PMC4672349. Bioscience Reports . 2015; 35.
Goyama S, Huang G, Kurokawa M, Mulloy J. Posttranslational Modifications of Runx1 as Potential Anticancer Targets. Oncogene . 2015; 34:3483-92.
Goyama S, Schibler J, Gasilina A, Shrestha M, Lin S, Link KA, Chen J, Whitman SP, Bloomfield CD, Nicolet D, Assi SA, Ptasinska A, Heidenreich O, Bonifer C, Kitamura T, Nassar NN, Mulloy JC. Ubash3b/Sts-1-Cbl Axis Regulates Myeloid Proliferation in Human Preleukemia Induced by Aml1-Eto. Leukemia . 2016; 30:728-39.
Gururangan S, Robinson G, Ellison DW, Wu G, He X, Lu QR, McLendon R, Grant G, Driscoll T, Neuberg R. Gorlin Syndrome and Desmoplastic Medulloblastoma: Report of 3 Cases with Unfavorable Clinical Course and Novel Mutations. Pediatr Blood Cancer . 2015; 62:1855-8.
Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast AM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A, Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA. Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-Like Megakaryocyte Progenitors. Cell Stem Cell . 2015; 17:422-34.
He D, Marie C, Zhao C, Kim B, Wang J, Deng Y, Clavairoly A, Frah M, Wang H, He X, Hmidan H, Jones BV, Witte D, Zalc B, Zhou X, Choo DI, Martin DM, Parras C, Lu QR. Chd7 Cooperates with Sox10 and Regulates the Onset of Cns Myelination and Remyelination. Nat Neurosci . 2016; 19:678-89.
Hoffman L, DeWire M, Ryall S, Buczkowicz P, Leach J, Miles L, Ramani A, Brudno M, Kumar S, Drissi R. Spatial Genomic Heterogeneity in Diffuse Intrinsic Pontine and Midline High-Grade Glioma: Implications for Diagnostic Biopsy and Targeted Therapeutics. pmc/PMC4700584. Acta Neuropathologica Communications . 2016; 4:1.
Imai F, Ladle D, Leslie J, Duan X, Rizvi T, Ciraolo G, Zheng Y, Yoshida Y. Synapse Formation in Monosynaptic Sensory-Motor Connections Is Regulated by Presynaptic Rho GTPase Cdc42. J Neurosci . 2016; 36:5724-35.
Joshi N, Kopec A, Ray J, Cline-Fedewa H, Nawabi A, Schmitt T, Nault R, Zacharewski T, Rockwell C, Flick M. Fibrin Deposition Following Bile Duct Injury Limits Fibrosis through an Alpha(M)Beta(2)-Dependent Mechanism. Blood . 2016; 127:2751-62.
Jousma E, Rizvi TA, Wu J, Janhofer D, Dombi E, Dunn RS, Kim MO, Masters AR, Jones DR, Cripe TP, Ratner N. Preclinical Assessments of the Mek Inhibitor Pd-0325901 in a Mouse Model of Neurofibromatosis Type 1. Pediatr Blood Cancer . 2015; 62:1709-16.
Juarez A, He D, Lu Q. Oligodendrocyte Progenitor Programming and Reprogramming: Toward Myelin Regeneration. Brain Research . 2016; 1638:209-20.
Kato Y, Alavattam K, Sin H-S, Meetei A, Pang Q, Andreassen P, Namekawa S. Fancb Is Essential in the Male Germline and Regulates H3k9 Methylation on the Sex Chromosomes During Meiosis. Hum Mol Genet . 2015; 24:5234-49.
Kesarwani M, Huber E, Kincaid Z, Evelyn CR, Biesiada J, Rance M, Thapa MB, Shah NP, Meller J, Zheng Y, Azam M. Targeting Substrate-Site in Jak2 Kinase Prevents Emergence of Genetic Resistance. Sci Rep . 2015; 5:14538.
Klionsky D, Abdelmohsen K, Abe A, Abedin M, Abeliovich H, Arozena A, Adachi H, Adams C, Adams P, Adeli Kea. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition). Autophagy . 2016; 12:1-222.
Ko Y-P, Flick M. Fibrinogen Is at the Interface of Host Defense and Pathogen Virulence in Staphylococcus Aureus Infection. Semin Thromb Hemost . 2016; 42:408-21.
Komurov K. Computational Approaches to Modeling of Molecular Interactions in Multicellular Systems . In: K M, ed. Intercellular Communication in Cancer . Dordrecht: Springer Netherlands; 2015:287-96.
Konstantinidis DG, Giger KM, Risinger M, Pushkaran S, Zhou P, Dexheimer P, Yerneni S, Andreassen P, Klingmuller U, Palis J, Zheng Y, Kalfa TA. Cytokinesis Failure in RhoA-Deficient Mouse Erythroblasts Involves Actomyosin and Midbody Dysregulation and Triggers P53 Activation. Blood . 2015; 126:1473-82.
Laitman B, Asp L, Mariani J, Zhang J, Liu J, Sawai S, Chapouly C, Horng S, Kramer E, Mitiku N. The Transcriptional Activator Kruppel-Like Factor-6 Is Required for Cns Myelination. Plos Biology . 2016; 14.
Li H, Zhao X, Yan X, Jessen WJ, Kim MO, Dombi E, Liu PP, Huang G, Wu J. Runx1 Contributes to Neurofibromatosis Type 1 Neurofibroma Formation. Oncogene . 2016; 35:1468-74.
Lin Y, Zheng Y. Approaches of Targeting Rho Gtpases in Cancer Drug Discovery. Expert Opin Drug Discov . 2015; 10:991-1010.
Lu F, Chen Y, Zhao C, Wang H, He D, Xu L, Wang J, He X, Deng Y, Lu EE, Liu X, Verma R, Bu H, Drissi R, Fouladi M, Stemmer-Rachamimov AO, Burns D, Xin M, Rubin JB, Bahassi el M, et al. Olig2-Dependent Reciprocal Shift in Pdgf and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma. Cancer Cell . 2016; 29:669-83.
Maiques-Diaz A, Hernando M, Sanchez-Lopez A, Rio-Machin A, Shrestha M, Mulloy J, Cigudosa J, Alvarez S. Mapk8-Mediated Stabilization of Sp1 Is Essential for Runx1-Runx1t1-Driven Leukaemia. Brit J Haematol . 2016; 172:807-10.
Malik P. Gene Therapy for Hemoglobinopathies: Tremendous Successes and Remaining Caveats. Mol Ther . 2016; 24:668-70.
Moehrle B, Nattamai K, Brown A, Florian M, Ryan M, Vogel M, Bliederhaeuser C, Soller K, Prows D, Abdollahi A. Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within Hscs and Upon Aging of Hscs. Cell Rep . 2015; 13:2412-24.
Moradi M, D, Malik P. The Current State-of-the-Art in Therapeutic Genome Editing and the Future. Gene Technol . 2016; 05.
Motley MP, Madsen DH, Jurgensen HJ, Spencer DE, Szabo R, Holmbeck K, Flick MJ, Lawrence DA, Castellino FJ, Weigert R, Bugge TH. A Ccr2 Macrophage Endocytic Pathway Mediates Extravascular Fibrin Clearance in Vivo. Blood . 2016; 127:1085-96.
Mpollo M-S, Brandt E, Shanmukhappa S, Arumugam P, Tiwari S, Loberg A, Pillis D, Rizvi T, Lindsey M, Jonck B. Placenta Growth Factor Augments Airway Hyperresponsiveness Via Leukotrienes and Il-13. J Clin Invest . 2016; 126:571-84.
Nasimuzzaman M, Lynn D, Ernst R, Beuerlein M, Smith R, Shrestha A, Cross S, Link K, Lutzko C, Nordling D. Production and Purification of High-Titer Foamy Virus Vector for the Treatment of Leukocyte Adhesion Deficiency. Mol Ther Methods Clin Dev . 2016; 3.
Nayak RC, Trump LR, Aronow BJ, Myers K, Mehta P, Kalfa T, Wellendorf AM, Valencia CA, Paddison PJ, Horwitz MS, Grimes HL, Lutzko C, Cancelas JA. Pathogenesis of ELANE-Mutant Severe Neutropenia Revealed by Induced Pluripotent Stem Cells. J Clin Invest . 2015; 125:3103-16.
Ngoc-Tung T, Su H, Khodadadi-Jamayran A, Lin S, Zhang L, Zhou D, Pawlik K, Townes T, Chen Y, Mulloy J. The as-Rbm15 LncRNA Enhances Rbm15 Protein Translation During Megakaryocyte Differentiation. Embo Reports . 2016; 17:887-900.
Niss O, Quinn CT, Lane A, Daily J, Khoury PR, Bakeer N, Kimball TR, Towbin JA, Malik P, Taylor MD. Cardiomyopathy with Restrictive Physiology in Sickle Cell Disease. JACC Cardiovasc Imaging . 2016; 9:243-52.
Nohata N, Uchida Y, Stratman AN, Adams RH, Zheng Y, Weinstein BM, Mukouyama YS, Gutkind JS. Temporal-Specific Roles of Rac1 During Vascular Development and Retinal Angiogenesis. Dev Biol . 2016; 411:183-94.
Park J, Virts E, Jankowska A, Wiek C, Othman M, Chakraborty S, Vance G, Alkuraya F, Hanenberg H, Andreassen P. Complementation of Hypersensitivity to DNA Interstrand Crosslinking Agents Demonstrates That Xrcc2 Is a Fanconi Anaemia Gene. J Med Genet . 2016.
Patel A, Johansson G, Colbert M, Dasgupta B, Ratner N. Fatty Acid Synthase Is a Metabolic Oncogene Targetable in Malignant Peripheral Nerve Sheath Tumors. Neuro-Oncology . 2015; 17:1599-608.
Pietras EM, Reynaud D, Kang YA, Carlin D, Calero-Nieto FJ, Leavitt AD, Stuart JM, Gottgens B, Passegué E. Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions. Cell Stem Cell . 2015; 17:35-46.
Prasad J, Gorkun O, Raghu H, Thornton S, Mullins E, Palumbo J, Ko Y-P, Höök M, David T, Coughlin S. Mice Expressing a Mutant Form of Fibrinogen That Cannot Support Fibrin Formation Exhibit Compromised Antimicrobial Host Defense. Blood . 2015; 126:2047-58.
Rao R, Salloum R, Xin M, Lu Q. The G Protein G Alpha(S) Acts as a Tumor Suppressor in Sonic Hedgehog Signaling-Driven Tumorigenesis. Cell Cycle . 2016; 15:1325-30.
Romick-Rosendale L, Hoskins E, Vinnedge L, Foglesong G, Brusadelli M, Potter S, Komurov K, Brugmann S, Lambert P, Kimple R. Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-Pk and Rac1 Signaling. Clin Cancer Res . 2016; 22:2062-73.
Rossi E, Smadja DM, Boscolo E, Langa C, Arevalo MA, Pericacho M, Gamella-Pozuelo L, Kauskot A, Botella LM, Gaussem P, Bischoff J, Lopez-Novoa JM, Bernabeu C. Endoglin Regulates Mural Cell Adhesion in the Circulatory System. Cell Mol Life Sci . 2016; 73:1715-39.
Sampson LL, Davis AK, Grogg MW, Zheng Y. mTOR Disruption Causes Intestinal Epithelial Cell Defects and Intestinal Atrophy Postinjury in Mice. FASEB J . 2016; 30:1263-75.
Segura-Cabrera A, Singh N, Komurov K. An Integrated Network Platform for Contextual Prioritization of Drugs and Pathways. Mol Biosyst . 2015; 11:2850-9.
Sertorio M, Amarachintha S, Wilson A, Pang Q. Loss of Fancc Impairs Antibody-Secreting Cell Differentiation in Mice through Deregulating the Wnt Signaling Pathway. J Immunol . 2016; 196:2986-94.
Thowfeik FS, AbdulSalam SF, Wunderlich M, Wyder M, Greis KD, Kadekaro AL, Mulloy JC, Merino EJ. A Ros-Activatable Agent Elicits Homologous Recombination DNA Repair and Synergizes with Pathway Compounds. Chembiochem . 2015; 16:2513-21.
Varney M, Niederkorn M, Konno H, Matsumura T, Gohda J, Yoshida N, Akiyama T, Christie S, Fang J, Miller D. Loss of Tifab, a Del(5q) Mds Gene, Alters Hematopoiesis through Derepression of Toll-Like Receptor-Traf6 Signaling. J Exp Med . 2015; 212:1967-85.
Varney ME, Melgar K, Niederkorn M, Smith MA, Barreyro L, Starczynowski DT. Deconstructing Innate Immune Signaling in Myelodysplastic Syndromes. Exp Hematol . 2015; 43:587-98.
Wong JC, Weinfurtner KM, Alzamora Mdel P, Kogan SC, Burgess MR, Zhang Y, Nakitandwe J, Ma J, Cheng J, Chen SC, Ho TT, Flach J, Reynaud D, Passegue E, Downing JR, Shannon K. Functional Evidence Implicating Chromosome 7q22 Haploinsufficiency in Myelodysplastic Syndrome Pathogenesis. Elife . 2015; 4.
Wu J, Huang G, Ratner N. Runx1: A New Driver in Neurofibromagenesis. Oncoscience . 2015; 2:904-5.
Wu J, Keng VW, Patmore DM, Kendall JJ, Patel AV, Jousma E, Jessen WJ, Choi K, Tschida BR, Silverstein KA, Fan D, Schwartz EB, Fuchs JR, Zou Y, Kim MO, Dombi E, Levy DE, Huang G, Cancelas JA, Stemmer-Rachamimov AO, et al. Insertional Mutagenesis Identifies a Stat3/Arid1b/Beta-Catenin Pathway Driving Neurofibroma Initiation. Cell Rep . 2016; 14:1979-90.
Yan J, Wang Q, Zou K, Wang L, Schwartz EB, Fuchs JR, Zheng Z, Wu J. Inhibition of the Jak2/Stat3 Signaling Pathway Exerts a Therapeutic Effect on Osteosarcoma. Mol Med Rep . 2015; 12:498-502.
Yang JQ, Kalim KW, Li Y, Zhang S, Hinge A, Filippi MD, Zheng Y, Guo F. RhoA Orchestrates Glycolysis for Th2 Cell Differentiation and Allergic Airway Inflammation. J Allergy Clin Immunol . 2016; 137:231-45 e4.
Yuasa M, Mignemi N, Nyman J, Duvall C, Schwartz H, Okawa A, Yoshii T, Bhattacharjee G, Zhao C, Bible J. Fibrinolysis Is Essential for Fracture Repair and Prevention of Heterotopic Ossification. J Clin Invest . 2015; 125:3117-31.
Zhang L, He X, Liu L, Jiang M, Zhao C, Wang H, He D, Zheng T, Zhou X, Hassan A. Hdac3 Interaction with P300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch. Developmental Cell . 2016; 36:316-30.
Zhang T, Wilson AF, Mahmood Ali A, Namekawa SH, Andreassen PR, Ruhikanta Meetei A, Pang Q. Loss of Faap20 Causes Hematopoietic Stem and Progenitor Cell Depletion in Mice under Genotoxic Stress. Stem Cells . 2015; 33:2320-30.
Zhao C, Deng Y, Liu L, Yu K, Zhang L, Wang H, He X, Wang J, Lu C, Wu L. Dual Regulatory Switch through Interactions of Tcf7l2/Tcf4 with Stage-Specific Partners Propels Oligodendroglial Maturation. Nat Commun . 2016; 7.