Cincinnati Center for Eosinophilic Disorders

Research and Publications

Melén E, Lambrecht BN, Lloyd CM, Rothenberg ME, Kabashima K, Luciani F, Coquet JM, Ober C, Nawijn MC, Platts-Mills T, von Mutius E. A conversation on allergy: recognizing the past and looking to the future. Immunol Cell Biol. 2023 Nov-Dec;101(10):936-946. doi: 10.1111/imcb.12688. PMID: 37688499.

Rothenberg ME, Dellon ES, Collins MH, Hirano I, Chehade M, Bredenoord AJ, Lucendo AJ, Spergel JM, Sun X, Hamilton JD, Mortensen E, Laws E, Maloney J, Mannent LP, McCann E, Liu X, Glotfelty L, Shabbir A. Efficacy and safety of dupilumab up to 52 weeks in adults and adolescents with eosinophilic oesophagitis (LIBERTY EoE TREET study): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Gastroenterol Hepatol. 2023 Nov;8(11):990-1004. doi: 10.1016/S2468-1253(23)00204-2. PMID: 37660704.

Siddiqui S, Wenzel SE, Bozik ME, Archibald DG, Dworetzky SI, Mather JL, Killingsworth R, Ghearing N, Schwartz JT, Ochkur SI, Jacobsen EA, Busse WW, Panettieri RA, Prussin C. Safety and efficacy of dexpramipexole in eosinophilic asthma (EXHALE): a randomized controlled trial. J Allergy Clin Immunol. 2023 Nov;152(5):1121-1130.e10. doi: 10.1016/j.jaci.2023.05.014. PMID: 37277072.

Sharlin CS, Mukkada VA, Putnam PE, Bolton SM. Treatment of pediatric eosinophilic esophagitis: traditional and novel therapies. Curr Gastroenterol Rep. 2023 Nov;25(11):289-298. doi: 10.1007/s11894-023-00893-6. PMID: 37658151.

Hiremath G, Sun L, Collins MH, Bonis PA, Arva NC, Capocelli KE, Chehade M, Davis CM, Falk GW, Gonsalves N, Gupta SK, Hirano I, Leung J, Khoury P, Mukkada VA, Martin LJ, Spergel JM, Wechsler JB, Yang GY, Aceves SS, Furuta GT, Rothenberg ME, Koyama T, Dellon ES. Esophageal epithelium and lamina propria are unevenly involved in eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2023 Oct;21(11):2807-2816.e3. doi: 10.1016/j.cgh.2023.03.014. PMID: 36967100; PMCID: PMC10518022.

Rochman Y, Kotliar M, Ben-Baruch Morgenstern N, Barski A, Wen T, Rothenberg ME. TSLP shapes the pathogenic responses of memory CD4+ T cells in eosinophilic esophagitis. Sci Signal. 2023 Sep 12;16(802):eadg6360. doi: 10.1126/scisignal.adg6360. PMID: 37699081; PMCID: PMC10602003.

Rochman M, Rochman Y, Caldwell JM, Mack LE, Besse JA, Manes NP, Yoon SH, Shoda T, Nita-Lazar A, Rothenberg ME. The minichromosome maintenance complex drives esophageal basal zone hyperplasia. JCI Insight. 2023 Sep 8;8(17):e172143. doi: 10.1172/jci.insight.172143. PMID: 37490338; PMCID: PMC10544209.

Kliewer KL, Murray-Petzold C, Collins MH, Abonia JP, Bolton SM, DiTommaso LA, Martin LJ, Zhang X, Mukkada VA, Putnam PE, Kellner ES, Devonshire AL, Schwartz JT, Kunnathur VA, Rosenberg CE, Lyles JL, Shoda T, Klion AD, Rothenberg ME. Benralizumab for eosinophilic gastritis: a single-site, randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Gastroenterol Hepatol. 2023 Sep;8(9):803-815. doi: 10.1016/S2468-1253(23)00145-0. PMID: 37336228; PMCID: PMC10529697.

Alexander RG, Ravi K, Collins MH, Lavey CJ, Snyder DL, Lennon RJ, Kassmeyer BA, Katzka DA, Alexander JA. Eosinophilic esophagitis histologic scoring system: correlation with histologic, endoscopic, and symptomatic disease and clinical use. Dig Dis Sci. 2023 Sep;68(9):3573-3583. doi: 10.1007/s10620-023-08029-6. PMID: 37432533.

Arnim UV, Biedermann L, Aceves SS, Bonis PA, Collins MH, Dellon ES, Furuta GT, Gonsalves N, Gupta S, Hirano I, Lucendo AJ, Miehlke S, Oliva S, Schlag C, Schoepfer A, Straumann A, Vieth M, Bredenoord AJ; EUREOS and TIGERs. Monitoring patients with eosinophilic esophagitis in routine clinical practice - international expert recommendations. Clin Gastroenterol Hepatol. 2023 Sep;21(10):2526-2533. doi: 10.1016/j.cgh.2022.12.018. PMID: 36572109.

Gonsalves N, Doerfler B, Zalewski A, Yang GY, Martin LJ, Zhang X, Shoda T, Brusilovsky M, Aceves S, Thompson K, Rudman Spergel AK, Furuta G, Rothenberg ME, Hirano I. Prospective study of an amino acid-based elemental diet in an eosinophilic gastritis and gastroenteritis nutrition trial. J Allergy Clin Immunol. 2023 Sep;152(3):676-688. doi: 10.1016/j.jaci.2023.05.024. PMID: 37462600; PMCID: PMC10528593.

Uchida AM, Burk CM, Rothenberg ME, Furuta GT, Spergel JM. Recent advances in the treatment of eosinophilic esophagitis. J Allergy Clin Immunol Pract. 2023 Sep;11(9):2654-2663. doi: 10.1016/j.jaip.2023.06.035. PMID: 37391018; PMCID: PMC10530275.

Aknin E, Larey A, Caldwell JM, Collins MH, Rothenberg ME, Savir Y. Harnessing digital pathology and causal learning to improve eosinophilic esophagitis dietary treatment assignment. 2023 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB). 2023:1-8. doi: 10.1109/CIBCB56990.2023.10264873.

Rothenberg ME. The immunology that underlies picky eating. Nature. 2023 Aug;620(7974):497-499. doi: 10.1038/d41586-023-02179-3. PMID: 37438630.

Parsons ES, Liu F, Kaushik A, Lee A, Schuetz J, Dunham D, Seastedt H, Ogulur I, Heider A, Tan G, Shah A, Cao S, Smith E, Kost L, Acharya S, Prunicki M, Rothenberg M, Sindher S, Leib R, Akdis CA, Nadeau K, Lejeune S. Detection of gut and mucosal peptides through TOMAHAQ in healthy individuals. Allergy. 2023 Jul;78(7):2052-2055. doi: 10.1111/all.15698. PMID: 36872560.

Chang JW, Kliewer K, Haller E, Lynett A, Doerfler B, Katzka DA, Peterson KA, Dellon ES, Gonsalves N; Consortium of Eosinophilic Gastrointestinal Disease Researchers. Development of a practical guide to implement and monitor diet therapy for eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2023 Jul;21(7):1690-1698. doi: 10.1016/j.cgh.2023.03.006. PMID: 36933603; PMCID: PMC10293042.

Ben-Baruch Morgenstern N, Shoda T, Rochman Y, Caldwell JM, Collins MH, Mukkada V, Putnam PE, Bolton SM, Felton JM, Rochman M, Murray-Petzold C, Kliewer KL, Rothenberg ME. Local type 2 immunity in eosinophilic gastritis. J Allergy Clin Immunol. 2023 Jul;152(1):136-144. doi: 10.1016/j.jaci.2023.01.021. PMID: 36754294; PMCID: PMC10330288.

Hwee J, Huynh L, Du S, Kwon N, Jakes RW, Alfonso-Cristancho R, Baylis L, Requena G, Khanal A, Rothenberg ME, Sheng Duh M. Hypereosinophilic syndrome in Europe: retrospective study of treatment patterns, clinical manifestations, and healthcare resource utilization. Ann Allergy Asthma Immunol. 2023 Jun;130(6):768-775. doi: 10.1016/j.anai.2023.02.022. PMID: 36863663.

Hirano I, Dellon ES, Gupta SK, Katzka DA, Collins MH, Wojtowicz AM, Terreri B, Zhang W, Boules M, Bhatia S, Desai NK. Editorial: safety of topical steroids designed specifically for eosinophilic oesophagitis - new data bring new questions. Authors' reply. Aliment Pharmacol Ther. 2023 May;57(10):1163-1165. doi: 10.1111/apt.17476. PMID: 37094318.

Guarnieri KM, Saba NK, Schwartz JT, Devonshire AL, Bufford J, Casale TB, Rothenberg ME, Andorf S. Food allergy characteristics associated with coexisting eosinophilic esophagitis in FARE Registry participants. J Allergy Clin Immunol Pract. 2023 May;11(5):1509-1521.e6. doi: 10.1016/j.jaip.2023.02.008. PMID: 36801492; PMCID: PMC10164686.

Sato H, Osonoi K, Sharlin CS, Shoda T. Genetic and molecular contributors in eosinophilic esophagitis. Curr Allergy Asthma Rep. 2023 May;23(5):255-266. doi: 10.1007/s11882-023-01075-0. PMID: 37084008; PMCID: PMC11136533.

Soh WT, Zhang J, Hollenberg MD, Vliagoftis H, Rothenberg ME, Sokol CL, Robinson C, Jacquet A. Protease allergens as initiators-regulators of allergic inflammation. Allergy. 2023 May;78(5):1148-1168. doi: 10.1111/all.15678. PMID: 36794967; PMCID: PMC10159943.

Hirano I, Dellon ES, Gupta SK, Katzka DA, Collins MH, Wojtowicz AM, Terreri B, Zhang W, Boules M, Bhatia S, Desai NK. Safety of an investigational formulation of budesonide (budesonide oral suspension) for eosinophilic oesophagitis: an integrated safety analysis of six phase 1-3 clinical trials. Aliment Pharmacol Ther. 2023 May;57(10):1117-1130. doi: 10.1111/apt.17430. PMID: 36890134.

Hirano I, Rothenberg ME, Zhang S, de Oliveira C, Charriez CM, Coyne KS, Bacci ED, Dellon ES. Dysphagia days as an assessment of clinical treatment outcome in eosinophilic esophagitis. Am J Gastroenterol. 2023 Apr 1;118(4):744-747. doi: 10.14309/ajg.0000000000002094. PMID: 36647838; PMCID: PMC10045973.

Talley NJ, Peterson KA, Genta RM, Chang AT, Dellon ES, Sandborn WJ; 019 Study Team; Lacy BE, Chehade M, Hirano I, Gonsalves N, Lembo A, Schmitt CM, Rothenberg ME, Jain N, Pletneva MA, Turner KO, Youngblood BA. High discovery rate of duodenal and gastric eosinophilia in patients with unexplained moderate-severe abdominal symptoms: a prospective US multisite study. Gastroenterology. 2023 Apr;164(4):680-683.e2. doi: 10.1053/j.gastro.2022.12.015. PMID: 36574864.

Applequist J, Burroughs C, Merkel PA, Rothenberg M, Trapnell B, Desnick R, Sahin M, Krischer J. Direct-to-consumer recruitment methods via traditional and social media to aid in research accrual for clinical trials for rare diseases: comparative analysis study. J Med Internet Res. 2023 Mar 14;25:e39262. doi: 10.2196/39262. PMID: 36917158; PMCID: PMC10131902.

Dellon ES, Rothenberg ME, Bredenoord AJ. Dupilumab in patients with eosinophilic esophagitis. Reply. N Engl J Med. 2023 Mar 9;388(10):956-957. doi: 10.1056/NEJMc2300703. PMID: 36884333.

Furuta GT, Fillon SA, Williamson KM, Robertson CE, Stevens MJ, Aceves SS, Arva NC, Chehade M, Collins MH, Davis CM, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I, Khoury P, Leung J, Martin LJ, Menard-Katcher P, Mukkada VA, Peterson K, Spergel JM, Wechsler JB, Yang GY, Rothenberg ME, Harris JK. Mucosal microbiota associated with eosinophilic esophagitis and eosinophilic gastritis. J Pediatr Gastroenterol Nutr. 2023 Mar 1;76(3):347-354. doi: 10.1097/MPG.0000000000003685. PMID: 36525669; PMCID: PMC10201396.

Xu J, Cai H, Wu Z, Li X, Tian C, Ao Z, Niu VC, Xiao X, Jiang L, Khodoun M, Rothenberg M, Mackie K, Chen J, Lee LP, Guo F. Acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand management of acute disease. Nat Commun. 2023 Feb 16;14(1):869. doi: 10.1038/s41467-023-36581-2. PMID: 36797284; PMCID: PMC9935629.

Avlas S, Shani G, Rhone N, Itan M, Dolitzky A, Hazut I, Grisaru-Tal S, Gordon Y, Shoda T, Ballaban A, Ben-Baruch NM, Rochman M, Diesendruck Y, Nahary L, Bitton A, Halpern Z, Benhar I, Varol C, Rothenberg ME, Munitz A. Epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis. Allergy. 2023 Feb;78(2):464-476. doi: 10.1111/all.15510. PMID: 36070083; PMCID: PMC9892241.

Chehade M, Furuta G, Klion A, Abonia JP, Aceves S, Bose P, Collins MH, Davis C, Dellon ES, Eickel G, Falk G, Gupta S, Hiremath G, Howard A, Jensen ET, Kesh S, Khoury P, Kocher K, Kodroff E, Kyle S, Mak N, McCoy D, Mehta P, Menard-Katcher P, Mukkada V, Paliana A, Rothenberg M, Sable K, Schmitt C, Scott M, Spergel J, Strobel MJ, Wechsler JB, Yang GY, Zicarelli A, Muir AB, Wright BL, Bailey DD. Enhancing diversity, equity, inclusion, and accessibility in eosinophilic gastrointestinal disease research: the consortium for eosinophilic gastrointestinal disease researchers' journey. Ther Adv Rare Dis. 2023 Aug 14;4:26330040231180895. doi: 10.1177/26330040231180895. PMID: 37588777; PMCID: PMC10426297.

Safroneeva E, Pan Z, King E, Martin LJ, Collins MH, Yang GY, Capocelli KE, Arva NC, Abonia JP, Atkins D, Bonis PA, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I, Leung J, Menard-Katcher PA, Mukkada VA, Schoepfer AM, Spergel JM, Wershil BK, Rothenberg ME, Aceves SS, Furuta GT; Consortium of Eosinophilic Gastrointestinal Disease Researchers. Long-Lasting Dissociation of esophageal eosinophilia and symptoms after dilation in adults with eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2022 Apr;20(4):766-775.e4. doi: 10.1016/j.cgh.2021.05.049. PMID: 34062314; PMCID: PMC8628021. 

Rothenberg ME, Hottinger SKB, Gonsalves N, Furuta GT, Collins MH, Talley NJ, Peterson K, Menard-Katcher C, Smith M, Hirano I, Genta RM, Chehade M, Gupta SK, Spergel JM, Aceves SS, Dellon ES. Impressions and aspirations from the FDA GREAT VI Workshop on eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis and perspectives for progress in the field. J Allergy Clin Immunol. 2022 Mar;149(3):844-853. doi: 10.1016/j.jaci.2021.12.768. PMID: 34953790; PMCID: PMC8901475. 

Dellon ES, Gonsalves N, Rothenberg ME, Hirano I, Chehade M, Peterson KA, Falk GW, Murray JA, Gehman LT, Chang AT, Singh B, Rasmussen HS, Genta RM. Determination of biopsy yield that optimally detects eosinophilic gastritis and/or duodenitis in a randomized trial of lirentelimab. Clin Gastroenterol Hepatol. 2022 Mar;20(3):535-545.e15. doi: 10.1016/j.cgh.2021.05.053. PMID: 34089846; PMCID: PMC8636525. 

Hirano I, Collins MH, Katzka DA, Mukkada VA, Falk GW, Morey R, Desai NK, Lan L, Williams J, Dellon ES; ORBIT1/SHP621-301 Investigators. Budesonide oral suspension improves outcomes in patients with eosinophilic esophagitis: results from a phase 3 trial. Clin Gastroenterol Hepatol. 2022 Mar;20(3):525-534.e10. doi: 10.1016/j.cgh.2021.04.022. PMID: 33887475. 

Min S, Shoda T, Wen T, Rothenberg ME. Diagnostic merits of the eosinophilic esophagitis diagnostic panel from a single esophageal biopsy. J Allergy Clin Immunol. 2022 Feb;149(2):782-787.e1. doi: 10.1016/j.jaci.2021.07.032. PMID: 34380050; PMCID: PMC8821114. 

Brusilovsky M, Bao R, Rochman M, Kemter AM, Nagler CR, Rothenberg ME. Host-microbiota interactions in the esophagus during homeostasis and allergic inflammation. Gastroenterology. 2022 Feb;162(2):521-534.e8. doi: 10.1053/j.gastro.2021.10.002. PMID: 34627858. 

Hiremath G, Sun L, Correa H, Acra S, Collins MH, Bonis P, Arva NC, Capocelli KE, Falk GW, King E, Gonsalves N, Gupta SK, Hirano I, Mukkada VA, Martin LJ, Putnam PE, Spergel JM, Wechsler JB, Yang GY, Aceves SS, Furuta GT, Rothenberg ME, Koyama T, Dellon ES. Development and validation of web-based tool to predict lamina propria fibrosis in eosinophilic esophagitis. Am J Gastroenterol. 2022 Feb 1;117(2):272-279. doi: 10.14309/ajg.0000000000001587. PMID: 34932022; PMCID: PMC8858426.

Turner KO, Collins MH, Walker MM, Genta RM. Quantification of mucosal eosinophils for the histopathologic diagnosis of eosinophilic gastritis and duodenitis: a primer for practicing pathologists. Am J Surg Pathol. 2022 Apr 1;46(4):557-566. doi: 10.1097/PAS.0000000000001843. PMID: 34913877; PMCID: PMC8923360.

Dunn JLM, Rothenberg ME. 2021 year in review: Spotlight on eosinophils. J Allergy Clin Immunol. 2022 Feb;149(2):517-524. doi: 10.1016/j.jaci.2021.11.012. PMID: 34838883.

Ma C, Jairath V, Feagan BG, Guizzetti L, Zou G, McFarlane SC, Shackelton LM, Collins MH, Hirano I, de Rooij WE, Schaeffer DF, Pai RK, Bredenoord AJ, Dellon ES. Responsiveness of a histologic scoring system compared with peak eosinophil count in eosinophilic esophagitis. Am J Gastroenterol. 2022 Feb 1;117(2):264-271. doi: 10.14309/ajg.0000000000001571. PMID: 34797816.

Shoda T, Wen T, Caldwell JM, Ben-Baruch Morgenstern N, Osswald GA, Rochman M, Mack LE, Felton JM, Abonia JP, Arva NC, Atkins D, Bonis PA, Capocelli KE, Collins MH, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I, Leung J, Menard-Katcher PA, Mukkada VA, Putnam PE, Rudman Spergel AK, Spergel JM, Wechsler JB, Yang GY, Aceves SS, Furuta GT, Rothenberg ME; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) Investigators Group. Loss of endothelial TSPAN12 promotes fibrostenotic eosinophilic esophagitis via endothelial cell-fibroblast crosstalk. Gastroenterology. 2022 Feb;162(2):439-453. doi: 10.1053/j.gastro.2021.10.016. PMID: 34687736; PMCID: PMC8792211.

Dellon ES, Rothenberg ME, Collins MH, Hirano I, Chehade M, Bredenoord AJ, Lucendo AJ, Spergel JM, Aceves S, Sun X, Kosloski MP, Kamal MA, Hamilton JD, Beazley B, McCann E, Patel K, Mannent LP, Laws E, Akinlade B, Amin N, Lim WK, Wipperman MF, Ruddy M, Patel N, Weinreich DR, Yancopoulos GD, Shumel B, Maloney J, Giannelou A, Shabbir A. Dupilumab in adults and adolescents with eosinophilic esophagitis. N Engl J Med. 2022 Dec 22;387(25):2317-2330. doi: 10.1056/NEJMoa2205982. PMID: 36546624.

Janarthanam R, Bolton SM, Wechsler JB. Role of mast cells in eosinophilic esophagitis. Curr Opin Gastroenterol. 2022 Nov 1;38(6):541-548. doi: 10.1097/MOG.0000000000000888. PMID: 36165008.

Larey A, Aknin E, Daniel N, Osswald GA, Caldwell JM, Rochman M, Wasserman T, Collins MH, Arva NC, Yang GY, Rothenberg ME, Savir Y. Harnessing artificial intelligence to infer novel spatial biomarkers for the diagnosis of eosinophilic esophagitis. Front Med (Lausanne). 2022 Oct 21;9:950728. doi: 10.3389/fmed.2022.950728. PMID: 36341260; PMCID: PMC9633847.

Rothenberg ME. Scientific journey to the first FDA-approved drug for eosinophilic esophagitis. J Allergy Clin Immunol. 2022 Dec;150(6):1325-1332. doi: 10.1016/j.jaci.2022.09.027. PMID: 36209816; PMCID: PMC9742179.

Schreiner P, Safroneeva E, Schoepfer A, Greuter T, Biedermann L, Schlag C, Labenz J, Auth MKH, Bredenoord AJ, Chang JW, Bonis PA, Rothenberg ME, Collins MH, Hirano I, Gupta SK, Katzka DA, Dellon ES, Straumann A, Furuta GT, Gonsalves N. Management of eosinophilic esophagitis associated food impaction in Europe and the United States. Dis Esophagus. 2022 Sep 14;35(9):doac003. doi: 10.1093/dote/doac003. PMID: 35088073.

Grisaru-Tal S, Rothenberg ME, Munitz A. Eosinophil-lymphocyte interactions in the tumor microenvironment and cancer immunotherapy. Nat Immunol. 2022 Sep;23(9):1309-1316. doi: 10.1038/s41590-022-01291-2. PMID: 36002647; PMCID: PMC9554620.

Aceves SS, Alexander JA, Baron TH, Bredenoord AJ, Day L, Dellon ES, Falk GW, Furuta GT, Gonsalves N, Hirano I, Konda VJA, Lucendo AJ, Moawad F, Peterson KA, Putnam PE, Richter J, Schoepfer AM, Straumann A, McBride DL, Sharma P, Katzka DA. Endoscopic approach to eosinophilic esophagitis: american society for gastrointestinal endoscopy consensus conference. Gastrointest Endosc. 2022 Oct;96(4):576-592.e1. doi: 10.1016/j.gie.2022.05.013. PMID: 35965102.

Tanzer J, Meng D, Ohsaki A, Caldwell JM, Mingler MK, Rothenberg ME, Oyoshi MK. Laundry detergent promotes allergic skin inflammation and esophageal eosinophilia in mice. PLoS One. 2022 Jun 27;17(6):e0268651. doi: 10.1371/journal.pone.0268651. PMID: 35759448; PMCID: PMC9236249.

Rochman M, Wen T, Kotliar M, Dexheimer PJ, Ben-Baruch Morgenstern N, Caldwell JM, Lim HW, Rothenberg ME. Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation. JCI Insight. 2022 Jun 8;7(11):e159093. doi: 10.1172/jci.insight.159093. PMID: 35472002; PMCID: PMC9208762.

Wright BL, Schwartz JT, Ruffner MA, Furuta GT, Gonsalves N, Dellon ES, Aceves SS. Eosinophilic gastrointestinal diseases make a name for themselves: A new consensus statement with updated nomenclature. J Allergy Clin Immunol. 2022 Aug;150(2):291-293. doi: 10.1016/j.jaci.2022.05.012. PMID: 35649464; PMCID: PMC9378528.

Dellon ES, Khoury P, Muir AB, Liacouras CA, Safroneeva E, Atkins D, Collins MH, Gonsalves N, Falk GW, Spergel JM, Hirano I, Chehade M, Schoepfer AM, Menard-Katcher C, Katzka DA, Bonis PA, Bredenoord AJ, Geng B, Jensen ET, Pesek RD, Feuerstadt P, Gupta SK, Lucendo AJ, Genta RM, Hiremath G, McGowan EC, Moawad FJ, Peterson KA, Rothenberg ME, Straumann A, Furuta GT, Aceves SS. A clinical severity index for eosinophilic esophagitis: development, consensus, and future directions. J Allergy Clin Immunol. 2022 Jul;150(1):33-47. doi: 10.1016/j.jaci.2022.03.015. PMID: 35606166; PMCID: PMC9549868.

Dellon ES, Khoury P, Muir AB, Liacouras CA, Safroneeva E, Atkins D, Collins MH, Gonsalves N, Falk GW, Spergel JM, Hirano I, Chehade M, Schoepfer AM, Menard-Katcher C, Katzka DA, Bonis PA, Bredenoord AJ, Geng B, Jensen ET, Pesek RD, Feuerstadt P, Gupta SK, Lucendo AJ, Genta RM, Hiremath G, McGowan EC, Moawad FJ, Peterson KA, Rothenberg ME, Straumann A, Furuta GT, Aceves SS. A clinical severity index for eosinophilic esophagitis: development, consensus, and future directions. Gastroenterology. 2022 Jul;163(1):59-76. doi: 10.1053/j.gastro.2022.03.025. PMID: 35606197; PMCID: PMC9233087.

Rothenberg ME, Roufosse F, Faguer S, Gleich GJ, Steinfeld J, Yancey SW, Mavropoulou E, Kwon N; HES Mepolizumab Study Group. Mepolizumab reduces hypereosinophilic syndrome flares irrespective of blood eosinophil count and interleukin-5. J Allergy Clin Immunol Pract. 2022 Sep;10(9):2367-2374.e3. doi: 10.1016/j.jaip.2022.04.037. PMID: 35568330.

Arva N, Genta RM, Pletneva M, Walker MM, Yang GY, Collins MH. Eosinophilic gastrointestinal disorders:a new path. Pediatr Dev Pathol. 2022 Sep-Oct;25(5):568-569. doi: 10.1177/10935266221096938. PMID: 35535658.

Dill-McFarland KA, Schwartz JT, Zhao H, Shao B, Fulkerson PC, Altman MC, Gill MA. Eosinophil-mediated suppression and anti-IL-5 enhancement of plasmacytoid dendritic cell interferon responses in asthma. J Allergy Clin Immunol. 2022 Sep;150(3):666-675. doi: 10.1016/j.jaci.2022.03.025. PMID: 35413355.

Robida PA, Rische CH, Morgenstern NB, Janarthanam R, Cao Y, Krier-Burris RA, Korver W, Xu A, Luu T, Schanin J, Leung J, Rothenberg ME, Wechsler JB, Youngblood BA, Bochner BS, O'Sullivan JA. Functional and phenotypic characterization of siglec-6 on human mast cells. Cells. 2022 Mar 28;11(7):1138. doi: 10.3390/cells11071138. PMID: 35406705; PMCID: PMC8997871.

Ben-Baruch Morgenstern N, Ballaban AY, Wen T, Shoda T, Caldwell JM, Kliewer K, Felton JM, Abonia JP, Mukkada VA, Putnam PE, Bolton SM, Dwyer DF, Barrett NA, Rothenberg ME. Single-cell RNA sequencing of mast cells in eosinophilic esophagitis reveals heterogeneity, local proliferation, and activation that persists in remission. J Allergy Clin Immunol. 2022 Jun;149(6):2062-2077. doi: 10.1016/j.jaci.2022.02.025. PMID: 35304158; PMCID: PMC9177790.

Kuang FL, De Melo MS, Makiya M, Kumar S, Brown T, Wetzler L, Ware JM, Khoury P, Collins MH, Quezado M, Pittaluga S, Klion AD. Benralizumab completely depletes gastrointestinal tissue eosinophils and improves symptoms in eosinophilic gastrointestinal disease. J Allergy Clin Immunol Pract. 2022 Jun;10(6):1598-1605.e2. doi: 10.1016/j.jaip.2022.02.037. PMID: 35283330; PMCID: PMC9210216.

Zhang S, Shoda T, Aceves SS, Arva NC, Chehade M, Collins MH, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I, Khoury P, Leung J, Spergel AKR, Spergel JM, Wechsler JB, Yang GY, Furuta GT, Rothenberg ME; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) Investigators Group. Mast cell-pain connection in eosinophilic esophagitis. Allergy. 2022 Jun;77(6):1895-1899. doi: 10.1111/all.15260. PMID: 35175645; PMCID: PMC9167217.

Hirano I, Collins MH, King E, Sun Q, Chehade M, Abonia JP, Bonis PA, Capocelli KE, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Leung J, Katzka D, Menard-Katcher P, Khoury P, Klion A, Mukkada VA, Peterson K, Shoda T, Rudman-Spergel AK, Spergel JA, Yang GY, Rothenberg ME, Aceves SS, Furuta GT; CEGIR investigators. Prospective endoscopic activity assessment for eosinophilic gastritis in a multisite cohort. Am J Gastroenterol. 2022 Mar 1;117(3):413-423. doi: 10.14309/ajg.0000000000001625. PMID: 35080202; PMCID: PMC8897269.

Rothenberg ME. The climate change hypothesis for the allergy epidemic. J Allergy Clin Immunol. 2022 May;149(5):1522-1524. doi: 10.1016/j.jaci.2022.02.006. PMID: 35192868.

Greuter T, Straumann A, Fernandez-Marrero Y, Germic N, Hosseini A, Yousefi S, Simon D, Collins MH, Bussmann C, Chehade M, Dellon ES, Furuta GT, Gonsalves N, Hirano I, Moawad FJ, Biedermann L, Safroneeva E, Schoepfer AM, Simon HU. Characterization of eosinophilic esophagitis variants by clinical, histological, and molecular analyses: A cross-sectional multi-center study. Allergy. 2022 Aug;77(8):2520-2533. doi: 10.1111/all.15233.PMID: 35094416; PMCID: PMC9545458.

Dellon ES, Gonsalves N, Abonia JP, Alexander JA, Arva NC, Atkins D, Attwood SE, Auth MKH, Bailey DD, Biederman L, Blanchard C, Bonis PA, Bose P, Bredenoord AJ, Chang JW, Chehade M, Collins MH, Di Lorenzo C, Dias JA, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox AT, Genta RM, Greuter T, Gupta SK, Hirano I, Hiremath GS, Horsley-Silva JL, Ishihara S, Ishimura N, Jensen ET, Gutiérrez-Junquera C, Katzka DA, Khoury P, Kinoshita Y, Kliewer KL, Koletzko S, Leung J, Liacouras CA, Lucendo AJ, Martin LJ, McGowan EC, Menard-Katcher C, Metz DC, Miller TL, Moawad FJ, Muir AB, Mukkada VA, Murch S, Nhu QM, Nomura I, Nurko S, Ohtsuka Y, Oliva S, Orel R, Papadopoulou A, Patel DA, Pesek RD, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Ruffner MA, Safroneeva E, Schreiner P, Schoepfer A, Schroeder SR, Shah N, Souza RF, Spechler SJ, Spergel JM, Straumann A, Talley NJ, Thapar N, Vandenplas Y, Venkatesh RD, Vieira MC, von Arnim U, Walker MM, Wechsler JB, Wershil BK, Wright BL, Yamada Y, Yang GY, Zevit N, Rothenberg ME, Furuta GT, Aceves SS. International consensus recommendations for eosinophilic gastrointestinal disease nomenclature. Clin Gastroenterol Hepatol. 2022 Nov;20(11):2474-2484.e3. doi: 10.1016/j.cgh.2022.02.017. PMID: 35181570; PMCID: PMC9378753.

Chen MM, Roufosse F, Wang SA, Verstovsek S, Durrani SR, Rothenberg ME, Pongdee T, Butterfield J, Lax T, Wechsler ME, Stein ML, Ogbogu PU, Kahwash BM, Mathur SK, Simon D, Akuthota P, Holland N, Wetzler L, Ware JM, Guo C, Fay MP, Khoury P, Klion AD, Bochner BS. An international, retrospective study of off-label biologic use in the treatment of hypereosinophilic syndromes. J Allergy Clin Immunol Pract. 2022 May;10(5):1217-1228.e3. doi: 10.1016/j.jaip.2022.02.006. PMID: 35181548; PMCID: PMC9086180.

Collins MH, Alexander ES, Martin LJ, Grotjan TM, Mukkada VA, Sheil A, Abonia JP, Putnam PE, Rothenberg ME. Acquired esophageal strictures in children: morphometric and immunohistochemical analyses. Pediatr Dev Pathol. 2022 Mar-Apr;25(2):124-133. doi: 10.1177/10935266211041086. PMID: 34515576; PMCID: PMC10102868.

Hiremath G, Sun L, Correa H, Acra S, Collins MH, Bonis P, Arva NC, Capocelli KE, Falk GW, King E, Gonsalves N, Gupta SK, Hirano I, Mukkada VA, Martin LJ, Putnam PE, Spergel JM, Wechsler JB, Yang GY, Aceves SS, Furuta GT, Rothenberg ME, Koyama T, Dellon ES. Development and validation of web-based tool to predict lamina propria fibrosis in eosinophilic esophagitis. Am J Gastroenterol. 2022 Feb 1;117(2):272-279. doi: 10.14309/ajg.0000000000001587. PMID: 34932022; PMCID: PMC8858426.

Droghini HR, Abonia JP, Collins MH, Milner JD, Lyons JJ, Freeman AF, Mukkada VA, Risma KA, Rothenberg ME, Schwartz JT. Targeted IL-4Rα blockade ameliorates refractory allergic eosinophilic inflammation in a patient with dysregulated TGF-β signaling due to ERBIN deficiency. J Allergy Clin Immunol Pract. 2022 Jul;10(7):1903-1906. doi: 10.1016/j.jaip.2022.01.012. PMID: 35093604; PMCID: PMC9271541.

Shoda T, Collins MH, Rochman M, Wen T, Caldwell JM, Mack LE, Osswald GA, Besse JA, Haberman Y, Aceves SS, Arva NC, Capocelli KE, Chehade M, Davis CM, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I, Khoury P, Klion A, Menard-Katcher C, Leung J, Mukkada VA, Putnam PE, Spergel JM, Wechsler JB, Yang GY, Furuta GT, Denson LA, Rothenberg ME; Consortium of Eosinophilic Gastrointestinal Diseases Researchers (CEGIR). Evaluating eosinophilic colitis as a unique disease using colonic molecular profiles: a multi-site study. Gastroenterology. 2022 May;162(6):1635-1649. doi: 10.1053/j.gastro.2022.01.022. PMID: 35085569; PMCID: PMC9038694.

Rothenberg ME. Linking the allergy epidemic to climate change. Nat Immunol. 2022 Feb;23(2):149. doi: 10.1038/s41590-021-01119-5. PMID: 35075280.