Research Focus Areas
Our clinical research has four main focuses:
- Identification of risk factors, exposures, healthcare disparities/SDOH, and environment interactions that lead to early childhood wheezing and severe asthma.
- Participation in NIH funded, multi-center asthma clinical trials in both preschool- and school-aged children.
- Participation in pharmaceutical trials to bring new pediatric asthma therapies to the market.
- Utilization of stakeholder input from patients, families, schools, community pediatricians, and medical providers to develop, implement, and test technology-based interventions for children with asthma.
Lab Projects
Preventing Asthma in High Risk Kids (PARK) Study
PARK study of omalizumab compared to placebo to reduce the diagnosis of childhood asthma in high risk 2-3-year-olds with a history of recurrent wheezing. This study is funded by the National Institutes of Health.
Oral Bacterial Extract (ORBEX) Study
ORBEX study of bronchovaxam compared to placebo to reduced the diagnosis of childhood wheezing and asthma in high risk 6-18-month-olds with personal or family history of allergic disease. This study is funded by the National Institutes of Health.
Asthma and Genetics of Obesity
A study to assess the intrinsic adipose tissue pathways that are associated with asthma and asthma-related morbidity in overweight/obese children with and without asthma. This study is funded by the National Institutes of Health.
Childhood Asthma in Urban Settings (CAUSE) Clinical Research Network
CAUSE conducts both network-wide and site-specific clinical studies and trials with the ultimate goal of developing effective asthma treatment and prevention approaches applicable to children residing in low-income urban settings.
Project Details
- Collaborators: Gurjit Khurana Hershey, MD, PhD
- Grants/Funding Information: National Institutes of Health
Tate Open-label Study
A study of benralizumab compared to placebo in 6-11 year olds with h/o severe eosinophilic asthma. This study is funded by AstraZeneca.
Rapid Observational Study
A study of dupilumab compared to placebo in 12+ year olds with severe eosinophilic asthma. This study is funded by Regeneron.
Swift Study
A study determining the efficacy and safety of Depemokimab compared to placebo in > 12 year olds with severe uncontrolled, eosinophilic asthma. This study is funded by GlaxoSmithKline.
Nimble Study
A study determining the efficacy and safety of Depemokimab compared to compared with continuation of mepolizumab or benralizumab in > 12 year olds with severe uncontrolled, eosinophilic asthma. This study is funded by GlaxoSmithKline.
Kalos Study
A study of Budesonide-Guaifenesin-Formoterol inhaler as compared to Budesonide/Formoterol in 12 year olds with moderate-severe asthma. This study is funded by AstraZeneca.
