Mizuno Lab

The Mizuno Lab at Cincinnati Children’s utilizes quantitative modeling and simulations, pharmacometrics, pharmacogenetics, and systems pharmacology approaches to develop and implement personalized precision dosing strategies in children and adults.

Most medications on the market come with dosage recommendations for the average patient. However, the optimal dose varies among patients due to substantial variability and complex interactions in patient physiology, drug response, and disease characteristics. Our overarching goal is to optimize drug dosing strategies by predicting drug behaviors, therapeutic efficacy, and disease profiles by using computational models at both population and individual levels.

Applying Mechanism-Based and Data-Driven Quantitative Modeling and Simulation for Personalized Precision Dosing

The Mizuno Lab also applies quantitative modeling and simulation technologies to facilitate safer, faster, and more cost-effective drug development through clinical trial design optimization, pediatric dose selection, implementing model-informed individualized dosing in clinical trials, and sophisticated pharmacometrics data analyses. We offer clinical pharmacology and model-informed drug development (MIDD) consulting for both academic programs and bio-pharmaceutical industries as part of Cincinnati Children’s Pharmacometric Services.