Ikegami Lab
Publications

Publications

Selected Publications

Gucwa, M; Ikegami, K. Lack of evidence for transcription-to-RNA maturation lags across G1-to-G2-phase boundary in fibroblasts. Life Science Alliance. 2026; 9(10).

Secchia, S; Beilinson, V; Chen, X; Gucwa, M; Denson, LA; Miraldi, ER; Weirauch, MT; Ikegami, K. Starvation activates ECM-remodeling gene transcription and putative enhancers in fibroblasts despite inducing quiescence. Cell reports. 2025; 44(7):115896.

En, A; Bogireddi, H; Thomas, B; Stutzman, AV; Ikegami, S; Laforest, B; Almakki, O; Pytel, P; Moskowitz, IP; Ikegami, K. Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice. Cell reports. 2024; 43(6):114284.

Steimle, JD; Kim, C; Rowton, M; Nadadur, RD; Wang, Z; Stocker, M; Hoffmann, AD; Hanson, E; Kweon, J; Sinha, T; Choi, K; Black, BL; Cunningham, JM; Moskowitz, IP; Ikegami, K. ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment. Cell reports. 2023; 42(6):112665.

Rowton, M; Perez-Cervantes, C; Hur, S; Jacobs-Li, J; Lu, E; Deng, N; Guzzetta, A; Hoffmann, AD; Stocker, M; Steimle, JD; Basu, A; Ikegami, K; Pott, S; Moskowitz, IP. Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages. Developmental Cell. 2022; 57(18):2181-2203.e9.

Rankin, SA; Steimle, JD; Yang, XH; Rydeen, AB; Agarwal, K; Chaturvedi, P; Ikegami, K; Herriges, MJ; Moskowitz, IP; Zorn, AM. Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development. eLife. 2021; 10.

Liu, SY; Ikegami, K. Nuclear lamin phosphorylation: an emerging role in gene regulation and pathogenesis of laminopathies. Nucleus. 2020; 11(1):299-314.

Ikegami, K; Secchia, S; Almakki, O; Lieb, JD; Moskowitz, IP. Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria. Developmental Cell. 2020; 52(6):699-713.e11.

Gucwa, M; Ikegami, K. Lack of evidence for transcription-to-RNA maturation lags across G1-to-G2-phase boundary in fibroblasts. Life Science Alliance. 2026; 9(10).

Secchia, S; Beilinson, V; Chen, X; Gucwa, M; Denson, LA; Miraldi, ER; Weirauch, MT; Ikegami, K. Starvation activates ECM-remodeling gene transcription and putative enhancers in fibroblasts despite inducing quiescence. Cell reports. 2025; 44(7):115896.

En, A; Bogireddi, H; Thomas, B; Stutzman, AV; Ikegami, S; Laforest, B; Almakki, O; Pytel, P; Moskowitz, IP; Ikegami, K. Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice. Cell reports. 2024; 43(6):114284.

Broman, MT; Nadadur, RD; Perez-Cervantes, C; Burnicka-Turek, O; Lazarevic, S; Gams, A; Laforest, B; Steimle, JD; Iddir, S; Wang, Z; Weber, CR; Mcnally, EM; Svensson, EC; Moskowitz, IP. A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. Circulation. 2024; 149(15):1205-1230.

Steimle, JD; Kim, C; Rowton, M; Nadadur, RD; Wang, Z; Stocker, M; Hoffmann, AD; Hanson, E; Kweon, J; Sinha, T; Choi, K; Black, BL; Cunningham, JM; Moskowitz, IP; Ikegami, K. ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment. Cell reports. 2023; 42(6):112665.

Rowton, M; Perez-Cervantes, C; Hur, S; Jacobs-Li, J; Lu, E; Deng, N; Guzzetta, A; Hoffmann, AD; Stocker, M; Steimle, JD; Basu, A; Ikegami, K; Pott, S; Moskowitz, IP. Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages. Developmental Cell. 2022; 57(18):2181-2203.e9.

Sinha, T; Lammerts Van Bueren, K; Dickel, DE; Zlatanova, I; Thomas, R; Lizama, CO; Xu, S-M; Zovein, AC; Ikegami, K; Moskowitz, IP; Pollard, KS; Pennacchio, LA; Black, BL. Differential Etv2 threshold requirement for endothelial and erythropoietic development. Cell reports. 2022; 39(9):110881.

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