Tilburgs Lab
Publications

Publications

Li, G; Mahajan, S; Ma, S; Jeffery, ED; Zhang, X; Bhattacharjee, A; Venkatasubramanian, M; Weirauch, MT; Miraldi, ER; Grimes, HL; Sheynkman, GM; Tilburgs, T; Salomonis, N. Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy. Science Translational Medicine. 2024; 16:eade2886.

Mahajan, S; Alexander, A; Koenig, Z; Saba, N; Prasanphanich, N; Hildeman, DA; Chougnet, CA; DeFranco, E; Andorf, S; Tilburgs, T. Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells. JCI insight. 2023; 8.

Crespo, AC; Mulik, S; Dotiwala, F; Ansara, JA; Sen Santara, S; Ingersoll, K; Ovies, C; Junqueira, C; Tilburgs, T; Strominger, JL; Lieberman, J. Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts. Cell. 2020; 182:1125-1139.e18.

Papuchova, H; Kshirsagar, S; Xu, L; Gomes, HA B; Li, Q; Iyer, V; Norwitz, ER; Strominger, JL; Tilburgs, T. Three types of HLA-G+ extravillous trophoblasts that have distinct immune regulatory properties. Proceedings of the National Academy of Sciences of USA. 2020; 117:15772-15777.

Vieira, RD M; Meagher, A; Crespo, AC; Kshirsagar, SK; Iyer, V; Norwitz, ER; Strominger, JL; Tilburgs, T. Human Term Pregnancy Decidual NK Cells Generate Distinct Cytotoxic Responses. Journal of immunology (Baltimore, Md. : 1950). 2020; 204:3149-3159.

Papuchova, H; Meissner, TB; Li, Q; Strominger, JL; Tilburgs, T. The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface. Frontiers in Immunology. 2019; 10:2730.

Salvany-Celades, M; van der Zwan, A; Benner, M; Setrajcic-Dragos, V; Gomes, HA B; Iyer, V; Norwitz, ER; Strominger, JL; Tilburgs, T. Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal Interface. Cell Reports. 2019; 27:2537-2547.e5.

van der Zwan, A; Bi, K; Norwitz, ER; Crespo, AC; Claas, FH J; Strominger, JL; Tilburgs, T. Mixed signature of activation and dysfunction allows human decidual CD8+ T cells to provide both tolerance and immunity. Proceedings of the National Academy of Sciences of USA. 2018; 115:385-390.

Ferreira, LM R; Meissner, TB; Tilburgs, T; Strominger, JL. HLA-G: At the Interface of Maternal-Fetal Tolerance. Trends in Immunology. 2017; 38:272-286.

Crespo, AC; Strominger, JL; Tilburgs, T. Expression of KIR2DS1 by decidual natural killer cells increases their ability to control placental HCMV infection. Proceedings of the National Academy of Sciences of USA. 2016; 113:15072-15077.

Tilburgs, T; Scherjon, SA; van der Mast, BJ; Haasnoot, GW; Versteeg-v.d. Voort-Maarschalk, M; Roelen, DL; van Rood, JJ; Claas, FH J. Fetal-maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells. Journal of Reproductive Immunology. 2009; 82:148-157.

Tilburgs, T; Roelen, DL; van der Mast, BJ; de Groot-Swings, GM; Kleijburg, C; Scherjon, SA; Claas, FH. Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy. Journal of immunology (Baltimore, Md. : 1950). 2008; 180:5737-5745.

Froehlich, F; Landerholm, K; Neeb, J; Meß, AK; Seiler, DL; Tilburgs, T; Karsten, CM. Emerging role of C5aR2: novel insights into the regulation of uterine immune cells during pregnancy. Frontiers in Immunology. 2024; 15:1411315.

DeTomaso, A; Kim, H; Shauh, J; Adulla, A; Zigo, S; Ghoul, M; Presicce, P; Kallapur, SG; Goodman, W; Tilburgs, T; Way, SS; Hackney, D; Moore, J; Mesiano, S. Progesterone inactivation in decidual stromal cells: A mechanism for inflammation-induced parturition. Proceedings of the National Academy of Sciences of USA. 2024; 121:e2400601121.

Tsuda, S; Shichino, S; Tilburgs, T; Shima, T; Morita, K; Yamaki-Ushijima, A; Roskin, K; Tomura, M; Sameshima, A; Saito, S; Nakashima, A. CD4+ T cell heterogeneity in gestational age and preeclampsia using single-cell RNA sequencing. Frontiers in Immunology. 2024; 15:1401738.

Li, G; Mahajan, S; Ma, S; Jeffery, ED; Zhang, X; Bhattacharjee, A; Venkatasubramanian, M; Weirauch, MT; Miraldi, ER; Grimes, HL; Sheynkman, GM; Tilburgs, T; Salomonis, N. Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy. Science Translational Medicine. 2024; 16:eade2886.

Mahajan, S; Alexander, A; Koenig, Z; Saba, N; Prasanphanich, N; Hildeman, DA; Chougnet, CA; DeFranco, E; Andorf, S; Tilburgs, T. Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells. JCI insight. 2023; 8.

Hamilton, I; Ikumi, NM; Kshirsagar, S; Goodman, WA; Tilburgs, T. Utilizing primary HLA-G+ extravillous trophoblasts and HLA-G+ EVT-like cell lines to study maternal-fetal interactions. Star Protocols. 2023; 4:102276.

Ikumi, NM; Koenig, Z; Mahajan, S; Gray, CM; Tilburgs, T. Purification of primary human placental leukocytes to study maternal-fetal interactions. Star Protocols. 2023; 4:102277.

Doll, JR; Moreno-Fernandez, ME; Stankiewicz, TE; Wayland, JL; Wilburn, A; Weinhaus, B; Chougnet, CA; Giordano, D; Cappelletti, M; Presicce, P; Kallapur, SG; Salomonis, N; Tilburgs, T; Divanovic, S. BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth. Cell Reports. 2023; 42:112352.

Severance, AL; Kinder, JM; Xin, L; Burg, AR; Shao, TY; Pham, G; Tilburgs, T; Goodman, WA; Mesiano, S; Way, SS. Maternal-fetal conflict averted by progesterone- induced FOXP3+ regulatory T cells. iScience. 2022; 25:104400.

Crespo, ÂC; Alexander, A; Tilburgs, T. Purification of Primary Decidual Natural Killer Cells for Functional Analysis. Methods in molecular biology (Clifton, N.J.). 2022; 2463:11-29.

Ikumi, NM; Pillay, K; Tilburgs, T; Malaba, TR; Dzanibe, S; Enninga, EA L; Chakraborty, R; Lamorde, M; Myer, L; Khoo, S; Jaspan, HB; Gray, CM. T-Cell Homeostatic Imbalance in Placentas From Women With Human Immunodeficiency Virus in the Absence of Vertical Transmission. The Journal of Infectious Diseases. 2021; 224:S670-S682.

Lekva, T; Roland, MC P; Estensen, ME; Norwitz, ER; Tilburgs, T; Henriksen, T; Bollerslev, J; Normann, KR; Magnus, P; Olstad, OK; Aukrust, P; Ueland, T. Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence. Scientific Reports. 2021; 11:19735.

Li, Q; Meissner, TB; Wang, F; Du, Z; Ma, S; Kshirsagar, S; Tilburgs, T; Buenrostro, JD; Uesugi, M; Strominger, JL. ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts. Proceedings of the National Academy of Sciences of USA. 2021; 118.

Tilburgs, T. Chapter 2 Presentation and recognition of placental, fetal, and pathogen-derived antigens in human pregnancy. Reproductive Immunology. : Elsevier; Elsevier; 2021.

Cappelletti, M; Doll, JR; Stankiewicz, TE; Lawson, MJ; Sauer, V; Wen, B; Kalinichenko, VV; Sun, X; Tilburgs, T; Divanovic, S. Maternal regulation of inflammatory cues is required for induction of preterm birth. JCI insight. 2020; 5.

Crespo, AC; Mulik, S; Dotiwala, F; Ansara, JA; Sen Santara, S; Ingersoll, K; Ovies, C; Junqueira, C; Tilburgs, T; Strominger, JL; Lieberman, J. Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts. Cell. 2020; 182:1125-1139.e18.

Papuchova, H; Kshirsagar, S; Xu, L; Gomes, HA B; Li, Q; Iyer, V; Norwitz, ER; Strominger, JL; Tilburgs, T. Three types of HLA-G+ extravillous trophoblasts that have distinct immune regulatory properties. Proceedings of the National Academy of Sciences of USA. 2020; 117:15772-15777.

Vieira, RD M; Meagher, A; Crespo, AC; Kshirsagar, SK; Iyer, V; Norwitz, ER; Strominger, JL; Tilburgs, T. Human Term Pregnancy Decidual NK Cells Generate Distinct Cytotoxic Responses. Journal of immunology (Baltimore, Md. : 1950). 2020; 204:3149-3159.

Ng, S; Norwitz, GA; Pavlicev, M; Tilburgs, T; Simon, C; Norwitz, ER. Endometrial Decidualization: The Primary Driver of Pregnancy Health. International Journal of Molecular Sciences. 2020; 21.