Pasare Lab

Publications

Carroll, SL; Pasare, C; Barton, GM. Control of adaptive immunity by pattern recognition receptors. Immunity. 2024; 57:632-648.

Meibers, HE; Warrick, KA; VonHandorf, A; Vallez, CN; Kawarizadeh, K; Saha, I; Donmez, O; Jain, VG; Kottyan, LC; Weirauch, MT; Pasare, C. Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells. Cell Reports. 2023; 42:113180.

Anna Nowacka, A; Pasare, C; Köhl, J. 70 C5a receptor 1 controls antigen and TLR-driven T cell proliferation and differentiation by splenic conventional type 2 dendritic cells. Immunobiology. 2023; 228:152521.

Overcast, GR; Meibers, HE; Eshleman, EM; Saha, I; Waggoner, L; Patel, KN; Jain, VG; Haslam, DB; Alenghat, T; Vandussen, KL; Pasare, C. IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation. The Journal of Experimental Medicine. 2023; 220:e20212523.

Choi, Y; Lichterman, JN; Coughlin, LA; Poulides, N; Li, W; Del Valle, P; Palmer, SN; Gan, S; Kim, J; Zhan, X; Gao, Y; Evers, BM; Hooper, LV; Pasare, C; Koh, AY. Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity. Science Immunology. 2023; 8:eabo2003.

Shi, T; Malik, A; vom Hofe, AY; Matuschek, L; Mullen, M; Lages, CS; Kudira, R; Singh, R; Zhang, W; Setchell, KD R; Hildeman, D; Pasare, C; Wagner, B; Miethke, AG. Farnesoid X receptor antagonizes macrophage-dependent licensing of effector T lymphocytes and progression of sclerosing cholangitis. Science Translational Medicine. 2022; 14:eabi4354.

Saha, I; Pasare, C. The B cell adapter for PI3K (BCAP) promotes M2 macrophage phenotype and safeguards tumors from immune surveillance. Journal of immunology (Baltimore, Md. : 1950). 2022; 208:61.08.

Kawarizadeh, K; Warrick, K; Pasare, C. BCAP plays a central role in regulating canonical M2 macrophage polarization upon various cell extrinsic signals. Journal of immunology (Baltimore, Md. : 1950). 2022; 208:111.04.

Meibers, H; McDaniel, MM; Jain, A; Chawla, AS; Pasare, C. Effector memory CD4 T cells engage myeloid cells through TNFR and CD40 to induce innate inflammation and autoimmune pathology independent of pattern recognition receptors. Journal of immunology (Baltimore, Md. : 1950). 2022; 208:164.19.

McDaniel, MM; Chawla, AS; Jain, A; Meibers, HE; Saha, I; Gao, Y; Jain, V; Roskin, K; Way, SS; Pasare, C. Effector memory CD4+ T cells induce damaging innate inflammation and autoimmune pathology by engaging CD40 and TNFR on myeloid cells. Science Immunology. 2022; 7:eabk0182.

McDaniel, MM; Meibers, HE; Pasare, C. Innate control of adaptive immunity and adaptive instruction of innate immunity: bi-directional flow of information. Current Opinion in Immunology. 2021; 73:25-33.

Brusilovsky, M; Rochman, M; Rochman, Y; Caldwell, JM; Mack, LE; Felton, JM; Habel, JE; Porollo, A; Pasare, C; Rothenberg, ME. Environmental allergens trigger type 2 inflammation through ripoptosome activation. Nature Immunology. 2021; 22:1316-1326.

Song, R; Gao, Y; Dozmorov, I; Malladi, V; Saha, I; McDaniel, MM; Parameswaran, S; Liang, C; Arana, C; Zhang, B; Weirauch, MT; Kottyan, LC; Wakeland, EK; Pasare, C. IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility. Cell Reports. 2021; 34:108891.

Irizarry-Caro, RA; McDaniel, MM; Overcast, GR; Jain, VG; Troutman, TD; Pasare, C. TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation. Proceedings of the National Academy of Sciences of USA. 2020; 117:30628-30638.

Raj, P; Song, R; Zhu, H; Riediger, L; Jun, DJ; Liang, C; Arana, C; Zhang, B; Gao, Y; Wakeland, BE; Zuo, X; Karp, DR; Li, QZ; Wakeland, EK. Deep sequencing reveals a DAP1 regulatory haplotype that potentiates autoimmunity in systemic lupus erythematosus. Genome Biology: biology for the post-genomic era. 2020; 21:281.

Zhang, J; Tracy, C; Pasare, C; Zeng, J; Kraemer, H. Hypersensitivity of Vps33B mutant flies to non-pathogenic infections is dictated by aberrant activation of p38b MAP kinase. Traffic. 2020; 21:578-589.

Jain, VG; Kong, F; Kallapur, SG; Presicce, P; Senthamaraikannnan, P; Cappelletti, M; Chougnet, CA; Bhattacharyya, S; Pasare, C; Muglia, LJ. IRAK1 Is a Critical Mediator of Inflammation-Induced Preterm Birth. Journal of immunology (Baltimore, Md. : 1950). 2020; 204:2651-2660.

McDaniel, MM; Kottyan, LC; Singh, H; Pasare, C. Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming. Cell Reports. 2020; 31:107604.

Overcast, G; Eshleman, E; Alenghat, T; Pasare, C. Epithelial cell intrinsic IL-1R signaling regulates intestinal homeostasis and inflammation. Journal of immunology (Baltimore, Md. : 1950). 2020; 204:235.6.

McDaniel, M; Pasare, C. Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs is Critical for T cell Priming. Journal of immunology (Baltimore, Md. : 1950). 2020; 204:69.5.

Meibers, H; McDaniel, M; Pasare, C. Vps33B is a crucial regulator of Type I Interferon response downstream of the cGAS-STING pathway. Journal of immunology (Baltimore, Md. : 1950). 2020; 204:68.13.

Gao, Y; Deason, K; Jain, A; Irizarry-Caro, RA; Dozmorov, I; Coughlin, LA; Rauch, I; Evers, BM; Koh, AY; Wakeland, EK; Pasare, C. Transcriptional profiling identifies caspase-1 as a T cell-intrinsic regulator of Th17 differentiation. The Journal of Experimental Medicine. 2020; 217:e20190476.

Antoniou, K; Ender, F; Vollbrandt, T; Laumonnier, Y; Rathmann, F; Pasare, C; Singh, H; Koehl, J. Allergen-Induced C5a/C5aR1 Axis Activation in Pulmonary CD11b+ cDCs Promotes Pulmonary Tolerance through Downregulation of CD40. Cells. 2020; 9:E300.

Jain, A; Irizarry-Caro, RA; McDaniel, MM; Chawla, AS; Carroll, KR; Overcast, GR; Philip, NH; Oberst, A; Chervonsky, AV; Katz, JD; Pasare, C. T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity. Nature Immunology. 2020; 21:65-74.