Lewkowich Lab

Publications

McAlees, JW; Baker, T; Houshel, L; McKnight, C; Lindsley, A; Strait, RT; Zhang, X; Cannata, A; Biagini, JM; Butsch Kovacic, M; Lewkowich, IP. Increased nasal epithelial cell responsiveness to IL-17A in paediatric asthmatics with low blood neutrophil count, low traffic-related air pollution exposure and good asthma control. Clinical and Experimental Allergy. 2022; 52:569-573.

McAlees, JW; Baker, T; Kaur, D; McKnight, C; Lindsley, A; Strait, RT; Zhang, X; Myers, JM B; Kovacic, MB; Lewkowich, IP. Age and early maternal smoking contribute to epithelial cell IL-13 responsiveness in a pediatric asthma population. Allergy: European Journal of Allergy and Clinical Immunology. 2019; 74:2485-2487.

Kim, D; McAlees, JW; Bischoff, LJ; Kaur, D; Houshel, LK; Gray, J; Hargis, J; Davis, X; Dudas, PL; Deshmukh, H; Lewkowich, IP. Combined administration of anti-IL-13 and anti-IL-17A at individually sub-therapeutic doses limits asthma-like symptoms in a mouse model of Th2/Th17 high asthma. Clinical and Experimental Allergy. 2019; 49:317-330.

Richgels, PK; Yamani, A; Chougnet, CA; Lewkowich, IP. Maternal house dust mite exposure during pregnancy enhances severity of house dust mite-induced asthma in murine offspring. Journal of Allergy and Clinical Immunology. 2017; 140:1404-1415.e9.

Hall, SL; Baker, T; Lajoie, S; Richgels, PK; Yang, Y; McAlees, JW; van Lier, A; Wills-Karp, M; Sivaprasad, U; Acciani, TH; LeCras, TD; Myers, JB; Kovacic, MB; Lewkowich, IP. IL-17A enhances IL-13 activity by enhancing IL-13-induced signal transducer and activator of transcription 6 activation. Journal of Allergy and Clinical Immunology. 2017; 139:462-471.e14.

McAlees, JW; Lajoie, S; Dienger, K; Sproles, AA; Richgels, PK; Yang, Y; Khodoun, M; Azuma, M; Yagita, H; Fulkerson, PC; Wills-Karp, M; Lewkowich, IP. Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma. European Journal of Immunology. 2015; 45:1019-1029.

Lewkowich, IP; Lajoie, S; Stoffers, SL; Suzuki, Y; Richgels, PK; Dienger, K; Sproles, AA; Yagita, H; Hamid, Q; Wills-Karp, M. PD-L2 modulates asthma severity by directly decreasing dendritic cell IL-12 production. Mucosal Immunology. 2013; 6:728-739.

Lajoie, S; Lewkowich, IP; Suzuki, Y; Clark, JR; Sproles, AA; Dienger, K; Budelsky, AL; Wills-Karp, M. Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Nature Immunology. 2010; 11:928-935.

Lewkowich, IP; Herman, NS; Schleifer, KW; Dance, MP; Chen, BL; Dienger, KM; Sproles, AA; Shah, JS; Kohl, J; Belkaid, Y; Wills-Karp, M. CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. The Journal of Experimental Medicine. 2005; 202:1549-1561.

Wilburn, AN; McAlees, JW; Haslam, DB; Graspeuntner, S; Schmudde, I; Laumonnier, Y; Rupp, J; Chougnet, CA; Deshmukh, H; Zacharias, WJ; König, P; Lewkowich, IP. Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice. American Journal of Respiratory Cell and Molecular Biology. 2023; 68:498-510.

Ghosh, D; McAlees, J; Bernstein, J; Lewkowich, I. Maternal Exposure To Phthalate Drives Skin Changes Associated With Increased Susceptibility To House Dust Mite Induced Atopic Dermatitis In Offspring. Journal of Allergy and Clinical Immunology. 2023; 151:ab150.

Lingel, I; Wilburn, AN; Hargis, J; McAlees, JW; Laumonnier, Y; Chougnet, CA; Deshmukh, H; König, P; Lewkowich, IP; Schmudde, I. Prenatal antibiotics exposure does not influence experimental allergic asthma in mice. Frontiers in Immunology. 2022; 13:937577.

Shankar, A; McAlees, JW; Lewkowich, IP. Modulation of IL-4/IL-13 cytokine signaling in the context of allergic disease. Journal of Allergy and Clinical Immunology. 2022; 150:266-276.

Stevens, J; Steinmeyer, S; Bonfield, M; Peterson, L; Wang, T; Gray, J; Lewkowich, I; Xu, Y; Du, Y; Guo, M; Miller, L; Chougnet, C; O’Connor, DH; Deshmukh, H. The balance between protective and pathogenic immune responses to pneumonia in the neonatal lung is enforced by gut microbiota. Science Translational Medicine. 2022; 14:eabl3981.

McAlees, JW; Baker, T; Houshel, L; McKnight, C; Lindsley, A; Strait, RT; Zhang, X; Cannata, A; Biagini, JM; Butsch Kovacic, M; Lewkowich, IP. Increased nasal epithelial cell responsiveness to IL-17A in paediatric asthmatics with low blood neutrophil count, low traffic-related air pollution exposure and good asthma control. Clinical and Experimental Allergy. 2022; 52:569-573.

Jackson, CM; Demmert, M; Mukherjee, S; Isaacs, T; Thompson, R; Chastain, C; Gray, J; Senthamaraikannan, P; Presicce, P; Chetal, K; Zacharias, WJ; Lewkowich, IP; Deshmukh, H; Chougnet, CA. A potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation. Mucosal Immunology. 2022; 15:730-744.

Toth, A; Steinmeyer, S; Kannan, P; Gray, J; Jackson, CM; Mukherjee, S; Demmert, M; Sheak, JR; Benson, D; Kitzmiller, J; Chougnet, CA; Jobe, AH; Deshmukh, H; Zacharias, WJ. Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates. Science Translational Medicine. 2022; 14:eabl8574.

Allgire, E; McAlees, JW; Lewkowich, IP; Sah, R. Asthma and posttraumatic stress disorder (PTSD): Emerging links, potential models and mechanisms. Brain, Behavior, and Immunity. 2021; 97:275-285.

Jackson, CM; Mukherjee, S; Wilburn, AN; Cates, C; Lewkowich, IP; Deshmukh, H; Zacharias, WJ; Chougnet, CA. Pulmonary Consequences of Prenatal Inflammatory Exposures: Clinical Perspective and Review of Basic Immunological Mechanisms. Frontiers in Immunology. 2020; 11:1285.

Oherle, K; Acker, E; Bonfield, M; Wang, T; Gray, J; Lang, I; Bridges, J; Lewkowich, I; Xu, Y; Ahlfeld, S; Zacharias, W; Alenghat, T; Deshmukh, H. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Immunity. 2020; 52:275-294.e9.

McAlees, JW; Baker, T; Kaur, D; McKnight, C; Lindsley, A; Strait, RT; Zhang, X; Myers, JM B; Kovacic, MB; Lewkowich, IP. Age and early maternal smoking contribute to epithelial cell IL-13 responsiveness in a pediatric asthma population. Allergy: European Journal of Allergy and Clinical Immunology. 2019; 74:2485-2487.

McMurray, KM J; Vollmer, LL; Ahlbrand, R; Thomas, J; Winter, A; Lewkowich, IP; Sah, R. Immunomodulatory T cell death associated gene-8 (TDAG8) receptor in depression-associated behaviors. Physiology and Behavior. 2019; 209:112598.

Brandt, EB; Lewkowich, IP. RAGE-induced asthma: A role for the receptor for advanced glycation end-products in promoting allergic airway disease. Journal of Allergy and Clinical Immunology. 2019; 144:651-653.

Schroeder, T; Wiese, AV; Ender, F; Quell, KM; Vollbrandt, T; Duhn, J; Suenderhauf, A; Kuenstner, A; Moreno-Fernandez, ME; Derer, S; Divanovic, S; Sina, C; Koehl, J; Laumonnier, Y. Short-term high-fat diet feeding protects from the development of experimental allergic asthma in mice. Clinical and Experimental Allergy. 2019; 49:1245-1257.

Kim, D; McAlees, JW; Bischoff, LJ; Kaur, D; Houshel, LK; Gray, J; Hargis, J; Davis, X; Dudas, PL; Deshmukh, H; Lewkowich, IP. Combined administration of anti-IL-13 and anti-IL-17A at individually sub-therapeutic doses limits asthma-like symptoms in a mouse model of Th2/Th17 high asthma. Clinical and Experimental Allergy. 2019; 49:317-330.