Herr Lab

Publications

Yarawsky, AE; Hopkins, JB; Chatzimagas, L; Hub, JS; Herr, AB. Solution Structural Studies of Pre-amyloid Oligomer States of the Biofilm Protein Aap. Journal of Molecular Biology. 2022; 434:167708.

Erickson, JJ; Archer-Hartmann, S; Yarawsky, AE; Miller, JL C; Seveau, S; Shao, TY; Severance, AL; Miller-Handley, H; Wu, Y; Pham, G; Lau, JT Y; Azadi, P; Herr, AB; Way, SS. Pregnancy enables antibody protection against intracellular infection. Nature. 2022; 606:769-775.

Gonzalez, T; Stevens, ML; Kyzy, AB; Alarcon, R; He, H; Kroner, JW; Spagna, D; Grashel, B; Sidler, E; Martin, LJ; Myers, JM B; Hershey, GK K; Herr, AB. Biofilm propensity of Staphylococcus aureus skin isolates is associated with increased atopic dermatitis severity and barrier dysfunction in the MPAACH pediatric cohort. Allergy: European Journal of Allergy and Clinical Immunology. 2021; 76:302-313.

Yarawsky, AE; Herr, AB. The staphylococcal biofilm protein Aap forms a tetrameric species as a necessary intermediate before amyloidogenesis. The Journal of biological chemistry. 2020; 295:12840-12850.

Yarawsky, AE; Johns, SL; Schuck, P; Herr, AB. The biofilm adhesion protein Aap from Staphylococcus epidermidis forms zinc-dependent amyloid fibers. The Journal of biological chemistry. 2020; 295:4411-4427.

Posgai, MT; Tonddast-Navaei, S; Jayasinghe, M; Ibrahim, GM; Stan, G; Herr, AB. FcαRI binding at the IgA1 CH2-CH3 interface induces long-range conformational changes that are transmitted to the hinge region. Proceedings of the National Academy of Sciences of USA. 2018; 115:E8882-E8891.

Shelton, CL; Conrady, DG; Herr, AB. Functional consequences of B-repeat sequence variation in the staphylococcal biofilm protein Aap: deciphering the assembly code. The Biochemical journal. 2017; 474:427-443.

Zhou, L; Hinerman, JM; Blaszczyk, M; Miller, JL C; Conrady, DG; Barrow, AD; Chirgadze, DY; Bihan, D; Farndale, RW; Herr, AB. Structural basis for collagen recognition by the immune receptor OSCAR. Blood. 2016; 127:529-537.

Strait, RT; Posgai, MT; Mahler, A; Barasa, N; Jacob, CO; Koehl, J; Ehlers, M; Stringer, K; Shanmukhappa, SK; Witte, D; Hossain, MM; Khodoun, M; Herr, AB; Finkelman, FD. IgG1 protects against renal disease in a mouse model of cryoglobulinaemia. Nature. 2015; 517:501-504.

Conrady, DG; Wilson, JJ; Herr, AB. Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms. Proceedings of the National Academy of Sciences of USA. 2013; 110:E202-E211.

Conrady, DG; Brescia, CC; Horii, K; Weiss, AA; Hassett, DJ; Herr, AB. A zinc-dependent adhesion module is responsible for intercellular adhesion in staphylococcal biofilms. Proceedings of the National Academy of Sciences of USA. 2008; 105:19456-19461.

Horii, K; Kahn, ML; Herr, AB. Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI. Blood. 2006; 108:936-942.

Herr, AB; Ballister, ER; Bjorkman, PJ. Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc. Nature. 2003; 423:614-620.

ORNITZ, DM; HERR, AB; NILSSON, M; WESTMAN, J; SVAHN, CM; WAKSMAN, G. FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides. Science. 1995; 268:432-436.

Mills, KB; Maciag, JJ; Wang, C; Crawford, JA; Enroth, TJ; Keim, KC; Dufrêne, YF; Robinson, DA; Fey, PD; Herr, AB; Horswill, AR. Staphylococcus aureus skin colonization is mediated by SasG lectin variation. Cell Reports. 2024; 43:114022.

Smith, CA; Sonneson, GJ; Hoey, RJ; Hinerman, JM; Sheehy, K; Walter, R; Herr, AB; Horn, JR. Molecular recognition requires dimerization of a VHH antibody. mAbs. 2023; 15:2215363.

Yarawsky, AE; Ori, AL; English, LR; Whitten, ST; Herr, AB. Convergent behavior of extended stalk regions from staphylococcal surface proteins with widely divergent sequence patterns. Protein Science. 2023; 32:e4707.

Yarawsky, AE; Dinu, V; Harding, SE; Herr, AB. Strong non-ideality effects at low protein concentrations: considerations for elongated proteins. European Biophysics Journal. 2023; 52:427-438.

Yadav, R; Shaikh, T; Tikole, S; Herr, AB; Fitzkee, NC. 1H, 15N, and 13C chemical shift backbone resonance NMR assignment of the accumulation-associated protein (Aap) lectin domain from Staphylococcus epidermidis. Biomolecular NMR Assignments. 2023; 17:95-99.

Kappes, EC; Kattamuri, C; Czepnik, M; Yarawsky, AE; Brûlé, E; Wang, Y; Ongaro, L; Herr, AB; Walton, KL; Bernard, DJ; Thompson, TB. Follistatin Forms a Stable Complex With Inhibin A That Does Not Interfere With Activin A Antagonism. Endocrinology. 2023; 164:bqad017.

Kleven, RT; Huang, S; Ford, SM; Sakthivel, K; Thomas, SR; Zuccarello, M; Herr, AB; Holland, CK. Effect of Recombinant Tissue Plasminogen Activator and 120-kHz Ultrasound on Porcine Intracranial Thrombus Density. Ultrasound in Medicine and Biology. 2023; 49:539-548.

Wang, C; Chantraine, C; Viljoen, A; Herr, AB; Fey, PD; Horswill, AR; Mathelié-Guinlet, M; Dufrêne, YF. The staphylococcal biofilm protein Aap mediates cell-cell adhesion through mechanically distinct homophilic and lectin interactions. Editor, Yooseph S. 2022; 1:pgac278.

Yarawsky, AE; Hopkins, JB; Chatzimagas, L; Hub, JS; Herr, AB. Solution Structural Studies of Pre-amyloid Oligomer States of the Biofilm Protein Aap. Journal of Molecular Biology. 2022; 434:167708.

Erickson, JJ; Archer-Hartmann, S; Yarawsky, AE; Miller, JL C; Seveau, S; Shao, TY; Severance, AL; Miller-Handley, H; Wu, Y; Pham, G; Lau, JT Y; Azadi, P; Herr, AB; Way, SS. Pregnancy enables antibody protection against intracellular infection. Nature. 2022; 606:769-775.

Locker, KC S; Kachapati, K; Wu, Y; Bednar, KJ; Adams, D; Patel, C; Tsukamoto, H; Heuer, LS; Aronow, BJ; Herr, AB; Ridgway, WM. Endosomal Sequestration of TLR4 Antibody Induces Myeloid-Derived Suppressor Cells and Reverses Acute Type 1 Diabetes. Diabetes. 2022; 71:470-482.

Borowska, MT; Drees, C; Yarawsky, AE; Viswanathan, M; Ryan, SM; Bunker, JJ; Herr, AB; Bendelac, A; Adams, EJ. The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe. Proceedings of the National Academy of Sciences of USA. 2021; 118:e2023898118.

Zamakhaeva, S; Chaton, CT; Rush, JS; Ajay Castro, S; Kenner, CW; Yarawsky, AE; Herr, AB; van Sorge, NM; Dorfmueller, HC; Frolenkov, GI; Korotkov, KV; Korotkova, N. Modification of cell wall polysaccharide guides cell division in Streptococcus mutans. Nature Chemical Biology. 2021; 17:878-887.

Locker, KC S; Herr, AB. Binding Proteins | Antibodies: Structure and Immune Effector Functions. Encyclopedia of Biological Chemistry III. : Elsevier; Elsevier; 2021.

Davis, G; York, AJ; Bacon, WC; Lin, SC; McNeal, MM; Yarawsky, AE; Maciag, JJ; Miller, JL C; Locker, KC S; Bailey, M; Jordan, MB; Herr, AB; Hildeman, DA; Molkentin, JD. Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020. Editor, Kumar B. PloS one. 2021; 16:e0254667.

Slater, A; Di, Y; Clark, JC; Jooss, NJ; Martin, EM; Alenazy, F; Thomas, MR; Ariëns, RA S; Herr, AB; Poulter, NS; Emsley, J; Watson, SP. Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer. Blood. 2021; 137:3443-3453.

Khodoun, MV; Morris, SC; Shao, WH; Potter, C; Angerman, E; Kiselev, A; Yarawsky, AE; Herr, AB; Klausz, K; Otte, A; Peipp, M; Finkelman, FD. Suppression of IgE-mediated anaphylaxis and food allergy with monovalent anti-FcεRIα mAbs. Journal of Allergy and Clinical Immunology. 2021; 147:1838-1854.e4.

Gonzalez, T; Stevens, ML; Kyzy, AB; Alarcon, R; He, H; Kroner, JW; Spagna, D; Grashel, B; Sidler, E; Martin, LJ; Myers, JM B; Hershey, GK K; Herr, AB. Biofilm propensity of Staphylococcus aureus skin isolates is associated with increased atopic dermatitis severity and barrier dysfunction in the MPAACH pediatric cohort. Allergy: European Journal of Allergy and Clinical Immunology. 2021; 76:302-313.

Stevens, ML; Gonzalez, T; Schauberger, E; Baatyrbek kyzy, A; Andersen, H; Spagna, D; Kalra, MK; Martin, LJ; Haslam, D; Herr, AB; Biagini Myers, JM; Khurana Hershey, GK. Simultaneous skin biome and keratinocyte genomic capture reveals microbiome differences by depth of sampling. Journal of Allergy and Clinical Immunology. 2020; 146:1442-1445.

DeVore, SB; Gonzalez, T; Sherenian, MG; Herr, AB; Khurana Hershey, GK. On the surface: Skin microbial exposure contributes to allergic disease. Annals of Allergy, Asthma, and Immunology. 2020; 125:628-638.

Yarawsky, AE; Herr, AB. The staphylococcal biofilm protein Aap forms a tetrameric species as a necessary intermediate before amyloidogenesis. The Journal of biological chemistry. 2020; 295:12840-12850.

Liu, S; Refaei, M; Liu, S; Decker, A; Hinerman, JM; Herr, AB; Howell, M; Musier-Forsyth, K; Tsang, P. Hairpin RNA-induced conformational change of a eukaryotic-specific lysyl-tRNA synthetase extension and role of adjacent anticodon-binding domain. The Journal of biological chemistry. 2020; 295:12071-12085.

Herr, AB. Secret(ory) revealed: the long-awaited structures of secretory IgA. Cell Research. 2020; 30:558-559.

Myers, JM B; Sherenian, MG; Kyzy, AB; Alarcon, R; An, A; Flege, Z; Morgan, D; Gonzalez, T; Stevens, ML; He, H; Grashel, B; Martin, LJ; Herr, AB; Hershey, GK K. Events in Normal Skin Promote Early-Life Atopic Dermatitis-The MPAACH Cohort. Journal of Allergy and Clinical Immunology: In Practice. 2020; 8:2285-2293.e6.

Yarawsky, AE; Johns, SL; Schuck, P; Herr, AB. The biofilm adhesion protein Aap from Staphylococcus epidermidis forms zinc-dependent amyloid fibers. The Journal of biological chemistry. 2020; 295:4411-4427.

Khodoun, MV; Morris, SC; Angerman, E; Potter, C; Schuman, R; Wunderlich, M; Maciag, JJ; Locker, KC S; Mulloy, JC; Herr, AB; Finkelman, FD. Rapid desensitization of humanized mice with anti-human FcεRIα monoclonal antibodies. Journal of Allergy and Clinical Immunology. 2020; 145:907-921.e3.

Myers, JB; Sherenian, M; Kyzy, AB; Alarcon, R; An, A; Flege, Z; Morgan, D; Gonzalez, T; Stevens, M; He, H; Grashel, B; Martin, L; Herr, A; Hershey, GK. The Mechanisms of Atopic Dermatitis to Asthma in Children (MPAACH) Cohort: Novel Atopic Dermatitis Endotypes. Journal of Allergy and Clinical Immunology. 2020; 145:ab337.