Chougnet Lab

Publications

Jackson, CM; Demmert, M; Mukherjee, S; Isaacs, T; Thompson, R; Chastain, C; Gray, J; Senthamaraikannan, P; Presicce, P; Chetal, K; Zacharias, WJ; Lewkowich, IP; Deshmukh, H; Chougnet, CA. A potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation. Mucosal Immunology. 2022; 15:730-744.

Toth, A; Steinmeyer, S; Kannan, P; Gray, J; Jackson, CM; Mukherjee, S; Demmert, M; Sheak, JR; Benson, D; Kitzmiller, J; Chougnet, CA; Jobe, AH; Deshmukh, H; Zacharias, WJ. Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates. Science Translational Medicine. 2022; 14:eabl8574.

Almanan, M; Raynor, J; Ogunsulire, I; Malyshkina, A; Mukherjee, S; Hummel, SA; Ingram, JT; Saini, A; Xie, MM; Alenghat, T; Dent, AL; Holscher, C; Chougnet, C; Hildeman, DA. IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression. Science Advances. 2020; 6:eabb0806.

Jackson, CM; Mukherjee, S; Wilburn, AN; Cates, C; Lewkowich, IP; Deshmukh, H; Zacharias, WJ; Chougnet, CA. Pulmonary Consequences of Prenatal Inflammatory Exposures: Clinical Perspective and Review of Basic Immunological Mechanisms. Frontiers in Immunology. 2020; 11:1285.

Roland, C; Senthamaraikannan, P; Chougnet, CA; Jobe, AH; Kallapur, SG. 111: IL-1 signaling mediates IL-6 expression at the maternal-fetal interface during intrauterine inflammation (IUI). American Journal of Obstetrics and Gynecology. 2018; 218:s80.

Rueda, CM; Lucia Rodriguez-Perea, A; Moreno-Fernandez, M; Jackson, CM; Melchior, JT; Davidson, WS; Chougnet, CA. High density lipoproteins selectively promote the survival of human regulatory T cells. Journal of Lipid Research. 2017; 58:1514-1523.

Jackson, CM; Wells, CB; Tabangin, ME; Meinzen-Derr, J; Jobe, AH; Chougnet, CA. Pro-inflammatory immune responses in leukocytes of premature infants exposed to maternal chorioamnionitis or funisitis. Pediatric Research. 2017; 81:384-390.

Rueda, CM; Jackson, CM; Chougnet, CA. Regulatory T-Cell-Mediated Suppression of Conventional T-Cells and Dendritic Cells by Different cAMP Intracellular Pathways. Frontiers in Immunology. 2016; 7:216.

Rueda, CM; Presicce, P; Jackson, CM; Miller, LA; Kallapur, SG; Jobe, AH; Chougnet, CA. Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1-Dependent Inflammatory FOXP3+ CD4+ T Cells in the Fetal Rhesus Macaque. Journal of immunology (Baltimore, Md. : 1950). 2016; 196:3706-3715.

Chougnet, CA; Thacker, RI; Shehata, HM; Hennies, CM; Lehn, MA; Lages, CS; Janssen, EM. Loss of Phagocytic and Antigen Cross-Presenting Capacity in Aging Dendritic Cells Is Associated with Mitochondrial Dysfunction. Journal of immunology (Baltimore, Md. : 1950). 2015; 195:2624-2632.

Raynor, J; Karns, R; Almanan, M; Li, K; Divanovic, S; Chougnet, CA; Hildeman, DA. IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age. Journal of immunology (Baltimore, Md. : 1950). 2015; 195:944-952.

Lo, B; Zhang, K; Lu, W; Zheng, L; Zhang, Q; Kanellopoulou, C; Zhang, Y; Liu, Z; Fritz, JM; Marsh, R; Su, HC; Rao, VK; Lenardo, MJ; Jordan, MB. AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy. Science. 2015; 349:436-440.

Moreno-Fernandez, ME; Joedicke, JJ; Chougnet, CA. Regulatory T Cells Diminish HIV Infection in Dendritic Cells - Conventional CD4(+) T Cell Clusters. Frontiers in Immunology. 2014; 5:199.

Raynor, J; Sholl, A; Plas, DR; Bouillet, P; Chougnet, CA; Hildeman, DA. IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels. Frontiers in Immunology. 2013; 4:161.

Moreno-Fernandez, ME; Mauricio Rueda, C; Rusie, LK; Chougnet, CA. Regulatory T cells control HIV replication in activated T cells through a cAMP-dependent mechanism. Blood. 2011; 117:5372-5380.

Moreno-Fernandez, ME; Zapata, W; Blackard, JT; Franchini, G; Chougnet, CA. Human regulatory T cells are targets for human immunodeficiency Virus (HIV) infection, and their susceptibility differs depending on the HIV type 1 strain. Journal of Virology. 2009; 83:12925-12933.

Lages, CS; Suffia, I; Velilla, PA; Huang, B; Warshaw, G; Hildeman, DA; Belkaid, Y; Chougnet, C. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. Journal of immunology (Baltimore, Md. : 1950). 2008; 181:1835-1848.

Nilsson, J; Boasso, A; Velilla, PA; Zhang, R; Vaccari, M; Franchini, G; Shearer, GM; Andersson, J; Chougnet, C. HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS. Blood. 2006; 108:3808-3817.

Zhang, R; Lifson, JD; Chougnet, C. Failure of HIV-exposed CD4+ T cells to activate dendritic cells is reversed by restoration of CD40/CD154 interactions. Blood. 2006; 107:1989-1995.

Andersson, J; Boasso, A; Nilsson, J; Zhang, R; Shire, NJ; Lindback, S; Shearer, GM; Chougnet, CA. The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients. Journal of immunology (Baltimore, Md. : 1950). 2005; 174:3143-3147.

Atehortua, L; Davidson, WS; Chougnet, CA. Interactions Between HDL and CD4+ T Cells: A Novel Understanding of HDL Anti-Inflammatory Properties. Arteriosclerosis, Thrombosis, and Vascular Biology. 2024; 44:1191-1201.

Presicce, P; Cappelletti, M; Morselli, M; Ma, F; Senthamaraikannan, P; Protti, G; Nadel, BB; Aryan, L; Eghbali, M; Salwinski, L; Pellegrini, M; Jobe, AH; Chougnet, CA; Kallapur, SG. Amnion responses to intrauterine inflammation and effects of inhibition of TNF signaling in preterm Rhesus macaque. iScience. 2023; 26:108118.

Thomas, AL; Godarova, A; Wayman, JA; Miraldi, ER; Hildeman, DA; Chougnet, CA. Accumulation of immune-suppressive CD4 + T cells in aging - tempering inflammaging at the expense of immunity. Seminars in Immunology. 2023; 70:101836.

Mahajan, S; Alexander, A; Koenig, Z; Saba, N; Prasanphanich, N; Hildeman, DA; Chougnet, CA; DeFranco, E; Andorf, S; Tilburgs, T. Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells. JCI insight. 2023; 8:e171806.

Atehortua, L; Morris, J; Street, SE; Bedel, N; Davidson, WS; Chougnet, CA. Apolipoprotein E-containing HDL decreases caspase-dependent apoptosis of memory regulatory T lymphocytes. Journal of Lipid Research. 2023; 64:100425.

Wilburn, AN; McAlees, JW; Haslam, DB; Graspeuntner, S; Schmudde, I; Laumonnier, Y; Rupp, J; Chougnet, CA; Deshmukh, H; Zacharias, WJ; König, P; Lewkowich, IP. Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice. American Journal of Respiratory Cell and Molecular Biology. 2023; 68:498-510.

Doll, JR; Moreno-Fernandez, ME; Stankiewicz, TE; Wayland, JL; Wilburn, A; Weinhaus, B; Chougnet, CA; Giordano, D; Cappelletti, M; Presicce, P; Kallapur, SG; Salomonis, N; Tilburgs, T; Divanovic, S. BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth. Cell Reports. 2023; 42:112352.

Thomas, AL; Wayman, JA; Almanan, M; Bejjani, AT; Miraldi, ER; Chougnet, CA; Hildeman, DA. Elevated CD153 Expression on Aged T Follicular Helper Cells is Vital for B cell Responses. 2023; 4:2023.03.17.533214.

Wayman, JA; Thomas, A; Bejjani, A; Katko, A; Almanan, M; Godarova, A; Korinfskaya, S; Cazares, TA; Yukawa, M; Kottyan, LC; Barski, A; Chougnet, CA; Hildeman, DA; Miraldi, ER. An atlas of gene regulatory networks for memory CD4 + T cells in youth and old age. 2023; 4:2023.03.07.531590.

Atehortua, L; Baig, M; Morris, J; Trentman, S; Davidson, WS; Fichtenbaum, CJ; Chougnet, CA. Impaired response of memory Treg to high density lipoproteins is associated with intermediate/high cardiovascular disease risk in persons with HIV. Frontiers in Immunology. 2023; 14:1146624.

Feria, MG; Chang, C; Ticona, E; Moussa, A; Zhang, B; Ballena, I; Azañero, R; Ticona, C; De Cecco, CN; Fichtenbaum, CJ; Katz, JD; Chougnet, CA; Deepe, GS; Huaman, MA. Pro-Inflammatory Alterations of Circulating Monocytes in Latent Tuberculosis Infection. Open Forum Infectious Diseases. 2022; 9:ofac629.

Thomas, AL; Lehn, MA; Janssen, EM; Hildeman, DA; Chougnet, CA. Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease. Scientific Reports. 2022; 12:19471.

Schmidt, AF; Schnell, DJ; Eaton, KP; Chetal, K; Kannan, PS; Miller, LA; Chougnet, CA; Swarr, DT; Jobe, AH; Salomonis, N; Kamath-Rayne, BD. Fetal maturation revealed by amniotic fluid cell-free transcriptome in rhesus macaques. JCI insight. 2022; 7:e162101.

Lingel, I; Wilburn, AN; Hargis, J; McAlees, JW; Laumonnier, Y; Chougnet, CA; Deshmukh, H; König, P; Lewkowich, IP; Schmudde, I. Prenatal antibiotics exposure does not influence experimental allergic asthma in mice. Frontiers in Immunology. 2022; 13:937577.

Stevens, J; Steinmeyer, S; Bonfield, M; Peterson, L; Wang, T; Gray, J; Lewkowich, I; Xu, Y; Du, Y; Guo, M; Miller, L; Chougnet, C; O’Connor, DH; Deshmukh, H. The balance between protective and pathogenic immune responses to pneumonia in the neonatal lung is enforced by gut microbiota. Science Translational Medicine. 2022; 14:eabl3981.

Atehortua, LM; Street, S; Davidson, WS; D'Alessandro, A; Chougnet, C. Apolipoprotein E enhance survival of effector memory regulatory T lymphocytes by regulating caspase-dependent apoptosis and lipid metabolism. Journal of immunology (Baltimore, Md. : 1950). 2022; 208:56.01.

Jackson, CM; Demmert, M; Mukherjee, S; Isaacs, T; Thompson, R; Chastain, C; Gray, J; Senthamaraikannan, P; Presicce, P; Chetal, K; Zacharias, WJ; Lewkowich, IP; Deshmukh, H; Chougnet, CA. A potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation. Mucosal Immunology. 2022; 15:730-744.

Toth, A; Steinmeyer, S; Kannan, P; Gray, J; Jackson, CM; Mukherjee, S; Demmert, M; Sheak, JR; Benson, D; Kitzmiller, J; Chougnet, CA; Jobe, AH; Deshmukh, H; Zacharias, WJ. Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates. Science Translational Medicine. 2022; 14:eabl8574.

van der Heijden, YF; Zhang, B; Chougnet, CA; Huaman, MA. Cytomegalovirus Infection Is Associated With Increased Prevalence of Latent Tuberculosis Infection. Open Forum Infectious Diseases. 2021; 8:ofab539.

Thomas, AL; Alarcon, PC; Divanovic, S; Chougnet, CA; Hildeman, DA; Moreno-Fernandez, ME. Implications of Inflammatory States on Dysfunctional Immune Responses in Aging and Obesity. Frontiers in Aging. 2021; 2:732414.

Cappelletti, M; Presicce, P; Feiyang, M; Senthamaraikannan, P; Miller, LA; Pellegrini, M; Sim, MS; Jobe, AH; Divanovic, S; Way, SS; Chougnet, CA; Kallapur, SG. The induction of preterm labor in rhesus macaques is determined by the  strength of immune response to intrauterine infection. Editor, Smith GC. PLoS biology. 2021; 19:e3001385.

Moreno-Fernandez, ME; Sharma, V; Stankiewicz, TE; Oates, JR; Doll, JR; Damen, MS M A; Almanan, MA T A; Chougnet, CA; Hildeman, DA; Divanovic, S. Aging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner. Nutrition and Diabetes. 2021; 11:15.

Schmidt, AF; Kannan, PS; Bridges, J; Presicce, P; Jackson, CM; Miller, LA; Kallapur, SG; Chougnet, CA; Jobe, AH. Prenatal inflammation enhances antenatal corticosteroid-induced fetal lung maturation. JCI insight. 2020; 5:e139452.

Almanan, M; Raynor, J; Ogunsulire, I; Malyshkina, A; Mukherjee, S; Hummel, SA; Ingram, JT; Saini, A; Xie, MM; Alenghat, T; Dent, AL; Holscher, C; Chougnet, C; Hildeman, DA. IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression. Science Advances. 2020; 6:eabb0806.

Jackson, CM; Mukherjee, S; Wilburn, AN; Cates, C; Lewkowich, IP; Deshmukh, H; Zacharias, WJ; Chougnet, CA. Pulmonary Consequences of Prenatal Inflammatory Exposures: Clinical Perspective and Review of Basic Immunological Mechanisms. Frontiers in Immunology. 2020; 11:1285.

Toothaker, JM; Presicce, P; Cappelletti, M; Stras, SF; McCourt, CC; Chougnet, CA; Kallapur, SG; Konnikova, L. Immune Cells in the Placental Villi Contribute to Intra-amniotic Inflammation. Frontiers in Immunology. 2020; 11:866.

Jain, VG; Kong, F; Kallapur, SG; Presicce, P; Senthamaraikannnan, P; Cappelletti, M; Chougnet, CA; Bhattacharyya, S; Pasare, C; Muglia, LJ. IRAK1 Is a Critical Mediator of Inflammation-Induced Preterm Birth. Journal of immunology (Baltimore, Md. : 1950). 2020; 204:2651-2660.

Presicce, P; Cappelletti, M; Senthamaraikannan, P; Ma, F; Morselli, M; Jackson, CM; Mukherjee, S; Miller, LA; Pellegrini, M; Jobe, AH; Chougnet, CA; Kallapur, SG. TNF-Signaling Modulates Neutrophil-Mediated Immunity at the Feto-Maternal Interface During LPS-Induced Intrauterine Inflammation. Frontiers in Immunology. 2020; 11:558.

Fisher, AL; Sangkhae, V; Presicce, P; Chougnet, CA; Jobe, AH; Kallapur, SG; Tabbah, S; Buhimschi, CS; Buhimschi, IA; Ganz, T; Nemeth, E. Fetal and amniotic fluid iron homeostasis in healthy and complicated murine, macaque, and human pregnancy. JCI insight. 2020; 5:135321.