A potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation. Mucosal Immunology. 2022; 15:730-744.
.Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates. Science Translational Medicine. 2022; 14:eabl8574.
.IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression. Science Advances. 2020; 6:eabb0806.
.Pulmonary Consequences of Prenatal Inflammatory Exposures: Clinical Perspective and Review of Basic Immunological Mechanisms. Frontiers in Immunology. 2020; 11:1285.
.2018; 218:s80.
. 111: IL-1 signaling mediates IL-6 expression at the maternal-fetal interface during intrauterine inflammation (IUI). American Journal of Obstetrics and Gynecology.High density lipoproteins selectively promote the survival of human regulatory T cells. Journal of Lipid Research. 2017; 58:1514-1523.
.Pro-inflammatory immune responses in leukocytes of premature infants exposed to maternal chorioamnionitis or funisitis. Pediatric Research. 2017; 81:384-390.
.Regulatory T-Cell-Mediated Suppression of Conventional T-Cells and Dendritic Cells by Different cAMP Intracellular Pathways. Frontiers in Immunology. 2016; 7:216.
.Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1-Dependent Inflammatory FOXP3+ CD4+ T Cells in the Fetal Rhesus Macaque. Journal of immunology (Baltimore, Md. : 1950). 2016; 196:3706-3715.
.Loss of Phagocytic and Antigen Cross-Presenting Capacity in Aging Dendritic Cells Is Associated with Mitochondrial Dysfunction. Journal of immunology (Baltimore, Md. : 1950). 2015; 195:2624-2632.
.IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age. Journal of immunology (Baltimore, Md. : 1950). 2015; 195:944-952.
.AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy. Science. 2015; 349:436-440.
.Regulatory T Cells Diminish HIV Infection in Dendritic Cells - Conventional CD4(+) T Cell Clusters. Frontiers in Immunology. 2014; 5:199.
.IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels. Frontiers in Immunology. 2013; 4:161.
.Regulatory T cells control HIV replication in activated T cells through a cAMP-dependent mechanism. Blood. 2011; 117:5372-5380.
.Human regulatory T cells are targets for human immunodeficiency Virus (HIV) infection, and their susceptibility differs depending on the HIV type 1 strain. Journal of Virology. 2009; 83:12925-12933.
.Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. Journal of immunology (Baltimore, Md. : 1950). 2008; 181:1835-1848.
.HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS. Blood. 2006; 108:3808-3817.
.Failure of HIV-exposed CD4+ T cells to activate dendritic cells is reversed by restoration of CD40/CD154 interactions. Blood. 2006; 107:1989-1995.
.The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients. Journal of immunology (Baltimore, Md. : 1950). 2005; 174:3143-3147.
.IL-1 and TNF mediates IL-6 signaling at the maternal-fetal interface during intrauterine inflammation. Frontiers in Immunology. 2024; 15:1416162.
.Interactions Between HDL and CD4+ T Cells: A Novel Understanding of HDL Anti-Inflammatory Properties. Arteriosclerosis, Thrombosis, and Vascular Biology. 2024; 44:1191-1201.
.Amnion responses to intrauterine inflammation and effects of inhibition of TNF signaling in preterm Rhesus macaque. iScience. 2023; 26:108118.
.Accumulation of immune-suppressive CD4 + T cells in aging - tempering inflammaging at the expense of immunity. Seminars in Immunology. 2023; 70:101836.
.Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells. JCI insight. 2023; 8.
.Apolipoprotein E-containing HDL decreases caspase-dependent apoptosis of memory regulatory T lymphocytes. Journal of Lipid Research. 2023; 64:100425.
.Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice. American Journal of Respiratory Cell and Molecular Biology. 2023; 68:498-510.
.BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth. Cell Reports. 2023; 42:112352.
.Elevated CD153 Expression on Aged T Follicular Helper Cells is Vital for B cell Responses. 2023.
.An atlas of gene regulatory networks for memory CD4 + T cells in youth and old age. 2023.
.Impaired response of memory Treg to high density lipoproteins is associated with intermediate/high cardiovascular disease risk in persons with HIV. Frontiers in Immunology. 2023; 14:1146624.
.Pro-Inflammatory Alterations of Circulating Monocytes in Latent Tuberculosis Infection. Open Forum Infectious Diseases. 2022; 9:ofac629.
.Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease. Scientific Reports. 2022; 12:19471.
.Fetal maturation revealed by amniotic fluid cell-free transcriptome in rhesus macaques. JCI insight. 2022; 7.
.Prenatal antibiotics exposure does not influence experimental allergic asthma in mice. Frontiers in Immunology. 2022; 13:937577.
.The balance between protective and pathogenic immune responses to pneumonia in the neonatal lung is enforced by gut microbiota. Science Translational Medicine. 2022; 14:eabl3981.
.2022; 208:56.01.
. Apolipoprotein E enhance survival of effector memory regulatory T lymphocytes by regulating caspase-dependent apoptosis and lipid metabolism. Journal of immunology (Baltimore, Md. : 1950).A potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation. Mucosal Immunology. 2022; 15:730-744.
.Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates. Science Translational Medicine. 2022; 14:eabl8574.
.Cytomegalovirus Infection Is Associated With Increased Prevalence of Latent Tuberculosis Infection. Open Forum Infectious Diseases. 2021; 8:ofab539.
.Implications of Inflammatory States on Dysfunctional Immune Responses in Aging and Obesity. Frontiers in Aging. 2021; 2:732414.
.The induction of preterm labor in rhesus macaques is determined by the strength of immune response to intrauterine infection. PLoS Biology. 2021; 19:e3001385.
.Aging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner. Nutrition and Diabetes. 2021; 11:15.
.Prenatal inflammation enhances antenatal corticosteroid-induced fetal lung maturation. JCI insight. 2020; 5.
.IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression. Science Advances. 2020; 6:eabb0806.
.Pulmonary Consequences of Prenatal Inflammatory Exposures: Clinical Perspective and Review of Basic Immunological Mechanisms. Frontiers in Immunology. 2020; 11:1285.
.Immune Cells in the Placental Villi Contribute to Intra-amniotic Inflammation. Frontiers in Immunology. 2020; 11:866.
.IRAK1 Is a Critical Mediator of Inflammation-Induced Preterm Birth. Journal of immunology (Baltimore, Md. : 1950). 2020; 204:2651-2660.
.TNF-Signaling Modulates Neutrophil-Mediated Immunity at the Feto-Maternal Interface During LPS-Induced Intrauterine Inflammation. Frontiers in Immunology. 2020; 11:558.
.Fetal and amniotic fluid iron homeostasis in healthy and complicated murine, macaque, and human pregnancy. JCI insight. 2020; 5.
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