Alenghat Lab

Publications

Eshleman, EM; Rice, T; Potter, C; Waddell, A; Hashimoto-Hill, S; Woo, V; Field, S; Engleman, L; Lim, HW; Schumacher, MA; Frey, MR; Denson, LA; Finkelman, FD; Alenghat, T. Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity. Immunity. 2024; 57:319-332.e6.

Eshleman, EM; Shao, TY; Woo, V; Rice, T; Engleman, L; Didriksen, BJ; Whitt, J; Haslam, DB; Way, SS; Alenghat, T. Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity. The Journal of Clinical Investigation. 2023; 133:e162190.

Woo, V; Eshleman, EM; Hashimoto-Hill, S; Whitt, J; Wu, SE; Engleman, L; Rice, T; Karns, R; Qualls, JE; Haslam, DB; Vallance, BA; Alenghat, T. Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection. Cell Host and Microbe. 2021; 29:1744-1756.e5.

Wu, S; Hashimoto-Hill, S; Woo, V; Eshleman, EM; Whitt, J; Engleman, L; Karns, R; Denson, LA; Haslam, DB; Alenghat, T. Microbiota-derived metabolite promotes HDAC3 activity in the gut. Nature. 2020; 586:108-112.

Oherle, K; Acker, E; Bonfield, M; Wang, T; Gray, J; Lang, I; Bridges, J; Lewkowich, I; Xu, Y; Ahlfeld, S; Zacharias, W; Alenghat, T; Deshmukh, H. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Immunity. 2020; 52:275-294.e9.

Kelly, D; Kotliar, M; Woo, V; Jagannathan, S; Whitt, J; Moncivaiz, J; Aronow, BJ; Dubinsky, MC; Hyams, JS; Markowitz, JF; Karns, R; Barski, A; Denson, LA; Alenghat, T. Microbiota-sensitive epigenetic signature predicts inflammation in Crohn's disease. JCI insight. 2018; 3:e122104.

Whitt, J; Woo, V; Lee, P; Moncivaiz, J; Haberman, Y; Denson, L; Tso, P; Alenghat, T. Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice. Gastroenterology. 2018; 155:501-513.

Jiang, TT; Shao, T; Ang, WX G; Kinder, JM; Turner, LH; Pham, G; Whitt, J; Alenghat, T; Way, SS. Commensal Fungi Recapitulate the Protective Benefits of Intestinal Bacteria. Cell Host and Microbe. 2017; 22:809-816.e4.

Whitsett, JA; Alenghat, T. Respiratory epithelial cells orchestrate pulmonary innate immunity. Nature Immunology. 2015; 16:27-35.

Alenghat, T; Osborne, LC; Saenz, SA; Kobuley, D; Ziegler, CG K; Mullican, SE; Choi, I; Grunberg, S; Sinha, R; Wynosky-Dolfi, M; Bushman, FD; Won, K; Lazar, MA; Artis, D. Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis. Nature. 2013; 504:153-157.

Didriksen, BJ; Eshleman, EM; Alenghat, T. Epithelial regulation of microbiota-immune cell dynamics. Mucosal Immunology. 2024; 17:303-313.

Eshleman, EM; Rice, T; Potter, C; Waddell, A; Hashimoto-Hill, S; Woo, V; Field, S; Engleman, L; Lim, HW; Schumacher, MA; Frey, MR; Denson, LA; Finkelman, FD; Alenghat, T. Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity. Immunity. 2024; 57:319-332.e6.

Velez Lopez, A; Waddell, A; Antonacci, S; Castillo, D; Santucci, N; Ollberding, NJ; Eshleman, EM; Denson, LA; Alenghat, T. Microbiota-derived butyrate dampens linaclotide stimulation of the guanylate cyclase C pathway in patient-derived colonoids. Neurogastroenterology and Motility. 2023; 35:e14681.

Eshleman, EM; Alenghat, T. Cleaving an epithelial path to food tolerance. Cell Research. 2023; 33:896-897.

Shao, TY; Jiang, TT; Stevens, J; Russi, AE; Troutman, TD; Bernieh, A; Pham, G; Erickson, JJ; Eshleman, EM; Alenghat, T; Weaver, CT; Haslam, DB; Deshmukh, H; Way, SS. Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation. Cell Reports. 2023; 42:113323.

Overcast, GR; Meibers, HE; Eshleman, EM; Saha, I; Waggoner, L; Patel, KN; Jain, VG; Haslam, DB; Alenghat, T; Vandussen, KL; Pasare, C. IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation. The Journal of Experimental Medicine. 2023; 220:e20212523.

Eshleman, EM; Shao, TY; Woo, V; Rice, T; Engleman, L; Didriksen, BJ; Whitt, J; Haslam, DB; Way, SS; Alenghat, T. Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity. The Journal of Clinical Investigation. 2023; 133:e162190.

Kharofa, J; Apewokin, S; Alenghat, T; Ollberding, NJ. Metagenomic analysis of the fecal microbiome in colorectal cancer patients compared to healthy controls as a function of age. Cancer Medicine. 2023; 12:2945-2957.

Woo, V; Alenghat, T. Epigenetic regulation by gut microbiota. Gut Microbes. 2022; 14:2022407.

Grasset, EK; Alenghat, T. Good intentions gone wrong: The B cell block to epithelial repair. Immunity. 2022; 55:2222-2224.

Fawad, JA; Luzader, DH; Hanson, GF; Moutinho, TJ; McKinney, CA; Mitchell, PG; Brown-Steinke, K; Kumar, A; Park, M; Lee, S; Alenghat, T; Hong, CI; Papin, JA; Moore, SR. Histone Deacetylase Inhibition by Gut Microbe-Generated Short-Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms. Gastroenterology. 2022; 163:1377-1390.e11.

Hashimoto-Hill, S; Colapietro, L; Woo, V; Antonacci, S; Whitt, J; Engleman, L; Alenghat, T. Dietary phytate primes epithelial antibacterial immunity in the intestine. Frontiers in Immunology. 2022; 13:952994.

Negi, S; Hashimoto-Hill, S; Alenghat, T. Neonatal microbiota-epithelial interactions that impact infection. Frontiers in Microbiology. 2022; 13:955051.

Gardner, L; Bayton, W; Hughes, J; Owen, L; Regada, S; Bochynska, D; Silva, J; Novo Matos, J. Unilateral external jugular vein aneurysm in a dog. Journal of Veterinary Cardiology. 2022; 41:39-43.

Eshleman, EM; Shao, T; Woo, V; Rice, T; Whitt, J; Engleman, L; Way, SS; Alenghat, T. Epithelial MHC class II directs microbiota-specific intestinal immune homeostasis. Journal of immunology (Baltimore, Md. : 1950). 2022; 208:115.03.

Woo, V; Eshleman, EM; Hashimoto-Hill, S; Whitt, J; Wu, SE; Engleman, L; Rice, T; Karns, R; Qualls, JE; Haslam, DB; Vallance, BA; Alenghat, T. Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection. Cell Host and Microbe. 2021; 29:1744-1756.e5.

Eshleman, EM; Alenghat, T. Epithelial sensing of microbiota-derived signals. Genes and Immunity. 2021; 22:237-246.

Hashimoto-Hill, S; Alenghat, T. Inflammation-Associated Microbiota Composition Across Domestic Animals. Frontiers in Genetics. 2021; 12:649599.

Hashimoto-Hill, S; Kelly, DR; Alenghat, T. Chapter 12 Epigenomics of intestinal disease. Medical Epigenetics. : Elsevier; Elsevier; 2021.

Wu, S; Hashimoto-Hill, S; Woo, V; Eshleman, EM; Whitt, J; Engleman, L; Karns, R; Denson, LA; Haslam, DB; Alenghat, T. Microbiota-derived metabolite promotes HDAC3 activity in the gut. Nature. 2020; 586:108-112.

Almanan, M; Raynor, J; Ogunsulire, I; Malyshkina, A; Mukherjee, S; Hummel, SA; Ingram, JT; Saini, A; Xie, MM; Alenghat, T; Dent, AL; Holscher, C; Chougnet, C; Hildeman, DA. IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression. Science Advances. 2020; 6:eabb0806.

Overcast, G; Eshleman, E; Alenghat, T; Pasare, C. Epithelial cell intrinsic IL-1R signaling regulates intestinal homeostasis and inflammation. Journal of immunology (Baltimore, Md. : 1950). 2020; 204:235.6.

Oherle, K; Acker, E; Bonfield, M; Wang, T; Gray, J; Lang, I; Bridges, J; Lewkowich, I; Xu, Y; Ahlfeld, S; Zacharias, W; Alenghat, T; Deshmukh, H. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Immunity. 2020; 52:275-294.e9.

Boucher, AA; Rosenfeldt, L; Mureb, D; Shafer, J; Sharma, BK; Lane, A; Crowther, RR; McKell, MC; Whitt, J; Alenghat, T; Mackman, N; Flick, MJ; Steinbrecher, KA; Palumbo, JS. Cell type-specific mechanisms coupling protease-activated receptor-1 to infectious colitis pathogenesis. Journal of Thrombosis and Haemostasis. 2020; 18:91-103.