Helmrath Lab

Publications

Swertfeger, D; Kim, A; Sexmith, H; Moreno-Fernandez, ME; Davidson, WS; Helmrath, M; Jenkins, T; Okura, T; Geh, E; Xanthakos, SA; Szabo, S; Nakamura, T; Divanovic, S; Shah, AS. Presurgery health influences outcomes following vertical sleeve gastrectomy in adolescents. Obesity. 2024; 32:1187-1197.

Pode-Shakked, N; Slack, M; Sundaram, N; Schreiber, R; McCracken, KW; Dekel, B; Helmrath, M; Kopan, R. RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis. Nature Communications. 2023; 14:8159.

Múnera, JO; Kechele, DO; Bouffi, C; Qu, N; Jing, R; Maity, P; Enriquez, JR; Han, L; Campbell, I; Mahe, MM; Hu, YC; Takebe, T; Helmrath, MA; Wells, JM. Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon. Cell Stem Cell. 2023; 30:1434-1451.e9.

Minneci, PC; Bergus, KC; Lutz, C; Aldrink, J; Bence, C; Breech, L; Dillon, PA; Downard, C; Ehrlich, PF; Fallat, M; Sato, TT; St Peter, SD; Cooper, J; Deans, K. Reducing Unnecessary Oophorectomies for Benign Ovarian Neoplasms in Pediatric Patients. Journal of the American Medical Association. 2023; 330:1247-1254.

Schaaf, L; Ley, S; Riegler, A; Poetker, A; Xanthakos, S; Sizemore, J; Crimmins, N; Helmrath, M; Tracy, R; Arce-Clachar, AC; Crail, J; Morwessel, N; Frenck, K; Tariq, F; Shah, AS. Development and Implementation of a Multidisciplinary Clinic Focused on the Care of Adolescents with Youth-Onset Type 2 Diabetes. Journal of Multidisciplinary Healthcare. 2023; 16:2799-2807.

Moran-Lev, H; Kocoshis, SA; Oliveira, SB; Helmrath, M; Cole, CR. Chronic Mucosal Inflammation in Pediatric Intestinal Failure Patients-A Unique Phenomenon. Journal of Pediatric Gastroenterology and Nutrition. 2023; 77:e29-e35.

Oliveira, S; Moran-Lev, H; Helmrath, M; Cole, C; Kocoshis, S. 84: Inflammatory Bowel Disease-Like Findings in Pediatric Intestinal Failure Patients. Transplantation. 2023; 107:50.

SHAH, AS; KELSEY, MM; JENKINS, TM; SCHAAF, LR; XANTHAKOS, S; TROUT, AT; BAUMGARTNER, AM Y; RIEGLER, A; KRISHNAN, N; BAILEY, A; INGE, T; HELMRATH, M; NADEAU, KJ. 1115-P: Advanced Medical Therapy (AMT) for Youth-Onset Type 2 Diabetes (T2D)—Early Results from the Run-in Phase of ST2OMP. Diabetes. 2023; 72.

SCHAAF, LR; CRAIL, J; XANTHAKOS, S; SIZEMORE, J; CRIMMINS, NA; HELMRATH, M; LEY, S; MORWESSEL, N; RIEGLER, A; TARIQ, F; SHAH, AS. 1105-P: Development and Implementation of a Multidisciplinary Clinic Focused on Youth-Onset Type 2 Diabetes. Diabetes. 2023; 72.

Bouffi, C; Wikenheiser-Brokamp, KA; Chaturvedi, P; Sundaram, N; Goddard, GR; Wunderlich, M; Brown, NE; Staab, JF; Latanich, R; Zachos, NC; Mulloy, JC; Zorn, AM; Wells, JM; Helmrath, MA. In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice. Nature Biotechnology. 2023; 41:824-831.

Arora, K; Sundaram, N; Ramananda, Y; Helmrath, M; Naren, AP. Applying patient personalized organoid model system to understand complex GI manifestations in cystic fibrosis disease. Physiology (Bethesda, Md.). 2023; 38:5711443.

Singh, A; Poling, HM; Chaturvedi, P; Thorner, K; Sundaram, N; Kechele, DO; Childs, CJ; McCauley, HA; Fisher, GW; Brown, NE; Spence, JR; Wells, JM; Helmrath, MA. Transplanted human intestinal organoids: a resource for modeling human intestinal development. Development (Cambridge). 2023; 150:dev201416.

Zeller, MH; Strong, H; Reiter-Purtill, J; Jenkins, TM; Mitchell, JE; Michalsky, MP; Helmrath, MA. Marijuana, e-cigarette, and tobacco product use in young adults who underwent pediatric bariatric surgery. Surgery for Obesity and Related Diseases. 2023; 19:512-521.

Gil, LA; Lutz, CM; Dillon, PA; Downard, CD; Ehrlich, PF; Fallat, ME; Fraser, JD; Grabowski, JE; Helmrath, MA; Hertweck, SP; Deans, KJ; Minneci, PC; Hewitt, GD; Aldrink, JH. Use and Accuracy of Intraoperative Frozen Section Analysis for Ovarian Masses in Children and Adolescents. Journal of Pediatric and Adolescent Gynecology. 2023; 36:155-159.

Marquart, JP; Bowder, AN; Bence, CM; St. Peter, SD; Gadepalli, SK; Sato, TT; Szabo, A; Minneci, PC; Hirschl, RB; Rymeski, BA; Silverberg, J; Slidell, MB; Wright, TN; Lal, DR. Thoracoscopy versus thoracotomy for esophageal atresia and tracheoesophageal fistula: Outcomes from the Midwest Pediatric Surgery Consortium. Journal of Pediatric Surgery. 2023; 58:27-33.

Rosselot, AE; Park, M; Kim, M; Matsu-Ura, T; Wu, G; Flores, DE; Subramanian, KR; Lee, S; Sundaram, N; Broda, TR; Wells, JM; Hogenesch, JB; Moore, SR; Hong, CI. Ontogeny and function of the circadian clock in intestinal organoids. The EMBO Journal. 2022; 41:e106973.

Fraser, JA; Deans, KJ; Fallat, ME; Helmrath, M; Kabre, R; Leys, CM; Markel, TA; Dillon, PA; Downard, C; Wright, TN; Sato, TT; Slater, BJ; Peter, SD S; Fraser, JD. Evaluating the risk of peri-umbilical hernia after sutured or sutureless gastroschisis closure. Journal of Pediatric Surgery. 2022; 57:786-791.

Chakrabarti, J; Dua-Awereh, M; Schumacher, M; Engevik, A; Hawkins, J; Helmrath, MA; Zavros, Y. Sonic Hedgehog acts as a macrophage chemoattractant during regeneration of the gastric epithelium. npj Regenerative Medicine. 2022; 7:3.

Kunisaki, SM; Saito, JM; Fallat, ME; Peter, SD S; Lal, DR; Karmakar, M; Deans, KJ; Gadepalli, SK; Hirschl, RB; Minneci, PC; Helmrath, MA. Fetal Risk Stratification and Outcomes in Children with Prenatally Diagnosed Lung Malformations: Results from a Multi-Institutional Research Collaborative. Annals of Surgery. 2022; 276:e622-e630.

Decker, KM; Reiter-Purtill, J; Bejarano, CM; Goldschmidt, AB; Mitchell, JE; Jenkins, TM; Helmrath, M; Inge, TH; Michalsky, MP; Zeller, MH. Psychosocial predictors of problematic eating in young adults who underwent adolescent bariatric surgery. Obesity Science and Practice. 2022; 8:545-555.

Pitstick, AL; Poling, HM; Sundaram, N; Lewis, PL; Kechele, DO; Sanchez, JG; Scott, MA; Broda, TR; Helmrath, MA; Wells, JM; Mayhew, CN. Aggregation of cryopreserved mid-hindgut endoderm for more reliable and reproducible hPSC-derived small intestinal organoid generation. Stem Cell Reports. 2022; 17:1889-1902.

Ding, L; Chakrabarti, J; Sheriff, S; Li, Q; Thi Hong, HN; Sontz, RA; Mendoza, ZE; Schreibeis, A; Helmrath, MA; Zavros, Y; Merchant, JL. Toll-like Receptor 9 Pathway Mediates Schlafen+-MDSC Polarization During Helicobacter-induced Gastric Metaplasias. Gastroenterology. 2022; 163:411-425.e4.

Engwall-Gill, AJ; Chan, SS; Boyd, KP; Saito, JM; Fallat, ME; St Peter, SD; Bolger-Theut, S; Crotty, EJ; Green, JR; Hulett Bowling, RL; Mak, GZ; Minneci, PC; Wright, TN; Kunisaki, SM. Accuracy of Chest Computed Tomography in Distinguishing Cystic Pleuropulmonary Blastoma From Benign Congenital Lung Malformations in Children. JAMA Network Open. 2022; 5:e2219814.

Bowder, AN; Bence, CM; Rymeski, BA; Gadepalli, SK; Sato, TT; Szabo, A; Arendonk, KV; Minneci, PC; Downard, CD; Hirschl, RB; St Peter, SD; Troutt, M; Wright, TN; Lal, DR. Acid suppression duration does not alter anastomotic stricture rates after esophageal atresia with distal tracheoesophageal fistula repair: A prospective multi-institutional cohort study. Journal of Pediatric Surgery. 2022; 57:975-980.

Minneci, PC; Hade, EM; Gil, LA; Metzger, GA; Saito, JM; Mak, GZ; Hirschl, RB; Gadepalli, S; Helmrath, MA; Leys, CM; Kabre, R; Fallat, ME; Cooper, JN; Deans, KJ. Demographic and Clinical Characteristics Associated With the Failure of Nonoperative Management of Uncomplicated Appendicitis in Children: Secondary Analysis of a Nonrandomized Clinical Trial. JAMA Network Open. 2022; 5:e229712.

Arora, K; Sundaram, N; Helmrath, M; Naren, AP. Mo1117: PATIENT PERSONALIZED TRANSLATIONAL TOOLS TO STUDY GI COMPLICATIONS IN CYSTIC FIBROSIS. Gastroenterology. 2022; 162:s-704-s-705.

Singh, A; Poling, HM; Sundaram, N; Wells, J; O'Connell, AE; Kovbasnjuk, O; Helmrath, M. 29: MESENCHYMAL WNT2B IS REQUIRED FOR MAINTENANCE OF THE HUMAN SMALL INTESTINAL EPITHELIUM. Gastroenterology. 2022; 162:s-11.

Dekonenko, C; Fraser, JD; Deans, K; Fallat, ME; Helmrath, M; Kabre, R; Leys, CM; Burns, RC; Corkum, K; Dillon, PA; Rymeski, B; Sato, TT; Slater, BJ; Peter, SS D. Does Use of a Feeding Protocol Change Outcomes in Gastroschisis? A Report from the Midwest Pediatric Surgery Consortium. European Journal of Pediatric Surgery. 2022; 32:153-159.

Capeling, MM; Huang, S; Childs, CJ; Wu, JH; Tsai, YH; Wu, A; Garg, N; Holloway, EM; Sundaram, N; Bouffi, C; Helmrath, M; Spence, JR. Suspension culture promotes serosal mesothelial development in human intestinal organoids. Cell Reports. 2022; 38:110379.

McNelis, K; Poindexter, A; Goddard, G; Riddle, S; Wessel, J; Helmrath, M. Body Composition of Infants With Congenital Gastroschisis. Journal of Pediatric Gastroenterology and Nutrition. 2022; 74:e35-e38.

Eicher, AK; Kechele, DO; Sundaram, N; Berns, HM; Poling, HM; Haines, LE; Sanchez, JG; Kishimoto, K; Krishnamurthy, M; Han, L; Zorn, AM; Helmrath, MA; Wells, JM. Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells. Cell Stem Cell. 2022; 29:36-51.e6.

Chakrabarti, J; Koh, V; Steele, N; Hawkins, J; Ito, Y; Merchant, JL; Wang, J; Helmrath, MA; Ahmad, SA; So, JB Y; Yong, WP; Zavros, Y. Disruption of Her2-Induced PD-L1 Inhibits Tumor Cell Immune Evasion in Patient-Derived Gastric Cancer Organoids. Cancers. 2021; 13:6158.

Chan, CC; Harley, IT W; Pfluger, PT; Trompette, A; Stankiewicz, TE; Allen, JL; Moreno-Fernandez, ME; Damen, MS M A; Oates, JR; Alarcon, PC; Seeley, RJ; Tschöp, MH; Karp, CL; Divanovic, S. A BAFF/APRIL axis regulates obesogenic diet-driven weight gain. Nature Communications. 2021; 12:2911.

Weller, JH; Peter, SD S; Fallat, ME; Saito, JM; Burns, CR; Deans, KJ; Fraser, JD; Gadepalli, SK; Helmrath, MA; Hirschl, RB; Mak, GZ; Minneci, PC; Wright, TN; Kunisaki, SM. Thoracoscopic versus open lobectomy in infants with congenital lung malformations: A multi-institutional propensity score analysis. Journal of Pediatric Surgery. 2021; 56:2148-2156.

Goddard, GR; McNelis, K; Poindexter, A; Jenkins, T; Wessel, J; Nathan, AT; Helmrath, MA; Poindexter, B. Quality Improvement Efforts Reduce Incidence of Surgical Necrotizing Enterocolitis and Related Deaths. American Journal of Perinatology: neonatal and maternal-fetal medicine. 2021; 38:1386-1392.

Criss, ZK; Bhasin, N; Di Rienzi, SC; Rajan, A; Deans-Fielder, K; Swaminathan, G; Kamyabi, N; Zeng, XL; Doddapaneni, H; Menon, VK; Crawford, SE; Estes, MK; Ramani, S; Shroyer, NF. Drivers of transcriptional variance in human intestinal epithelial organoids. Physiological Genomics. 2021; 53:486-508.

Koh, V; Chakrabarti, J; Torvund, M; Steele, N; Hawkins, JA; Ito, Y; Wang, J; Helmrath, MA; Merchant, JL; Ahmed, SA; Shabbir, A; Yan So, JB; Yong, WP; Zavros, Y. Hedgehog transcriptional effector GLI mediates mTOR-Induced PD-L1 expression in gastric cancer organoids. Cancer Letters. 2021; 518:59-71.

Shah, AS; Helmrath, MA; Inge, TH; Xanthakos, SA; Kelsey, MM; Jenkins, T; Trout, AT; Browne, L; Nadeau, KJ. Study protocol: a prospective controlled clinical trial to assess surgical or medical treatment for paediatric type 2 diabetes (ST2OMP). BMJ Open. 2021; 11:e047766.

Lim, II P; Cushing, CC; Jenkins, T; Troutt, M; Zeller, MH; Hossain, M; Rymeski, B; Helmrath, M; Frischer, JS. Prospective quality of life outcomes in pediatric fecal incontinence following bowel management. Journal of Pediatric Surgery. 2021; 56:1459-1464.

Dekonenko, C; Fraser, JD; Deans, KJ; Fallat, ME; Helmrath, M; Kabre, R; Leys, CM; Burns, RC; Corkumd, K; Dillon, PA; Rymeski, B; Sato, TT; Slater, BJ; St. Peter, SD. Outcomes in gastroschisis: expectations in the postnatal period for simple vs complex gastroschisis. Journal of Perinatology. 2021; 41:1755-1759.

Kasendra, M; Troutt, M; Broda, T; Bacon, WC; Wang, TC; Niland, JC; Helmrath, MA. Intestinal organoids: roadmap to the clinic. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2021; 321:G1-G10.

Moreno-Fernandez, ME; Giles, DA; Oates, JR; Chan, CC; Damen, MS M A; Doll, JR; Stankiewicz, TE; Chen, X; Chetal, K; Karns, R; Inge, TH; Deshmukh, H; Salomonis, N; Divanovic, S. PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease. Cell Metabolism. 2021; 33:1187-1204.e9.

Arora, K; Yang, F; Brewington, J; McPhail, G; Cortez, AR; Sundaram, N; Ramananda, Y; Ogden, H; Helmrath, M; Clancy, JP; Naren, AP. Patient personalized translational tools in cystic fibrosis to transform data from bench to bed-side and back. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2021; 320:G1123-G1130.

Kunisaki, SM; Lal, DR; Saito, JM; Fallat, ME; St. Peter, SD; Fox, ZD; Heider, A; Chan, SS; Boyd, KP; Burns, RC; Mak, GZ; Minneci, PC; Wright, TN; Helmrath, MA. Pleuropulmonary Blastoma in Pediatric Lung Lesions. Pediatrics. 2021; 147:e2020028357.

Bence, CM; Rymeski, B; Gadepalli, S; Sato, TT; Minneci, PC; Downard, C; Hirschl, RB; Amin, RA; Burns, RC; Cherney-Stafford, L; Troutt, M; Walker, S; Wright, T; Lal, DR. Clinical outcomes following implementation of a management bundle for esophageal atresia with distal tracheoesophageal fistula. Journal of Pediatric Surgery. 2021; 56:47-54.

McNelis, K; Goddard, G; Jenkins, T; Poindexter, A; Wessel, J; Helmrath, M; Poindexter, B. Delay in achieving enteral autonomy and growth outcomes in very low birth weight infants with surgical necrotizing enterocolitis. Journal of Perinatology. 2021; 41:150-156.

Chan, CC; Damen, MS M A; Moreno-Fernandez, ME; Stankiewicz, TE; Cappelletti, M; Alarcon, PC; Oates, JR; Doll, JR; Mukherjee, R; Chen, X; Karns, R; Weirauch, MT; Helmrath, MA; Inge, TH; Divanovic, S. Type I interferon sensing unlocks dormant adipocyte inflammatory potential. Nature Communications. 2020; 11:2745.

McCauley, HA; Matthis, AL; Enriquez, JR; Nichol, JT; Sanchez, JG; Stone, WJ; Sundaram, N; Helmrath, MA; Montrose, MH; Aihara, E; Wells, JM. Enteroendocrine cells couple nutrient sensing to nutrient absorption by regulating ion transport. Nature Communications. 2020; 11:4791.

Fraser, JD; Deans, KJ; Fallat, ME; Helmrath, MA; Kabre, R; Leys, CM; Burns, RC; Corkum, K; Dillon, PA; Downard, CD; Slater, BJ; Wilkinson, KH; Wright, TN; St. Peter, SD. Sutureless vs sutured abdominal wall closure for gastroschisis: Operative characteristics and early outcomes from the Midwest Pediatric Surgery Consortium. Journal of Pediatric Surgery. 2020; 55:2284-2288.

Valvi, D; Walker, DI; Inge, T; Bartell, SM; Jenkins, T; Helmrath, M; Ziegler, TR; La Merrill, MA; Eckel, SP; Conti, D; Liang, Y; Jones, DP; McConnell, R; Chatzi, L. Environmental chemical burden in metabolic tissues and systemic biological pathways in adolescent bariatric surgery patients: A pilot untargeted metabolomic approach. Environment International. 2020; 143:105957.

Singh, A; Poling, HM; Spence, JR; Wells, JM; Helmrath, MA. Gastrointestinal organoids: a next-generation tool for modeling human development. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2020; 319:G375-G381.

Singh, A; Poling, HM; Sundaram, N; Brown, N; Wells, JM; Helmrath, MA. Evaluation of transplantation sites for human intestinal organoids. Editor, Papaccio G. PloS one. 2020; 15:e0237885.

Minneci, PC; Hade, EM; Lawrence, AE; Sebastiao, YV; Saito, JM; Mak, GZ; Fox, C; Hirschl, RB; Gadepalli, S; Helmrath, MA; Fallat, ME; Cooper, JN; Deans, KJ; Consortium, MP S. Association of Nonoperative Management Using Antibiotic Therapy vs Laparoscopic Appendectomy With Treatment Success and Disability Days in Children With Uncomplicated Appendicitis. Journal of the American Medical Association. 2020; 324:581-593.

Kunisaki, SM; Saito, JM; Fallat, ME; Peter, SD S; Lal, DR; Johnson, KN; Mon, RA; Adams, C; Aladegbami, B; Bence, C; Walker, SK; Wright, TN; Hirschl, RB; Consortium, MP S. Development of a multi-institutional registry for children with operative congenital lung malformations. Journal of Pediatric Surgery. 2020; 55:1313-1318.

Dewberry, LC; Jalivand, A; Gupta, R; Jenkins, TM; Beamish, A; Inge, TH; Courcoulas, A; Helmrath, M; Brandt, ML; Harmon, CM; Chen, M; Dixon, JB; Zeller, M; Michalsky, MP. Weight Loss and Health Status 5 Years After Adjustable Gastric Banding in Adolescents. Obesity Surgery. 2020; 30:2388-2394.

Arora, K; Yang, F; Brewington, J; Cortez, AR; Sundaram, N; Ramananda, Y; Herbert, O; Helmrath, M; Naren, AP. Su1243 BENCH TO BED-SIDE AND BACK TRANSLATION IN CF USING PATIENT-DERIVED STEM-CELL BASED MODEL SYSTEMS. Gastroenterology. 2020; 158:s-555.

Xanthakos, SA; Khoury, JC; Inge, TH; Jenkins, TM; Modi, AC; Michalsky, MP; Chen, MK; Courcoulas, AP; Harmon, CM; Brandt, ML; Helmrath, MA; Kalkwarf, HJ; Bariatric, LA. Nutritional Risks in Adolescents After Bariatric Surgery. Clinical Gastroenterology and Hepatology. 2020; 18:1070-1081.e5.

DUA-AWEREH, MB; Chakrabarti, J; Hawkins, J; Wang, J; Diwan, T; Helmrath, M; Zavros, Y. 19 OVEREXPRESSION OF CD44V9/SIALYL-LEWIS X METAPLASIA DURING REGENERATION RESULTS IN INCREASED HELICOBACTER PYLORI-INDUCED GASTRIC LOCALIZATION AND DISEASE. Gastroenterology. 2020; 158:s-7.

Shah, AS; Nadeau, KJ; Helmrath, MA; Inge, TH; Xanthakos, SA; Kelsey, MM. Metabolic outcomes of surgery in youth with type 2 diabetes. Seminars in Pediatric Surgery. 2020; 29:150893.

Sitzman, TJ; Carle, AC; Lundberg, JN; Heaton, PC; Helmrath, MA; Trotman, C; Britto, MT. Marked Variation Exists Among Surgeons and Hospitals in the Use of Secondary Cleft Lip Surgery. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. 2020; 57:198-207.

Lamoshi, A; Chernoguz, A; Harmon, CM; Helmrath, M. Complications of bariatric surgery in adolescents. Seminars in Pediatric Surgery. 2020; 29:150888.

Vales, S; Poling, HM; Sundaram, N; Helmrath, MA; Mahe, MM. In Vivo Human PSC-Derived Intestinal Organoids to Study Stem Cell Maintenance. Methods in molecular biology (Clifton, N.J.). 2020; 2171:201-214.

Pradhan, S; Karve, SS; Weiss, AA; Hawkins, J; Poling, HM; Helmrath, MA; Wells, JM; McCauley, HA. Tissue Responses to Shiga Toxin in Human Intestinal Organoids. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2020; 10:171-190.

Leys, CM; Hirschl, RB; Kohler, JE; Cherney-Stafford, L; Marka, N; Fallat, ME; Gadepalli, SK; Fraser, JD; Grabowski, J; Burns, RC; St Peter, SD; Warner, BW; Ostlie, DJ; MWP, MP S C. Changing the Paradigm for Management of Pediatric Primary Spontaneous Pneumothorax: A Simple Aspiration Test Predicts Need for Operation. Journal of Pediatric Surgery. 2020; 55:169-175.