Lu Lab

Publications

Luo, Z; Xin, D; Liao, Y; Berry, K; Ogurek, S; Zhang, F; Zhang, L; Zhao, C; Rao, R; Dong, X; Zhou, W; Weiss, WA; Andreassen, P; Lu, QR. Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability. Nature Communications. 2023; 14:762.

Hu, X; Wu, X; Berry, K; Zhao, C; Xin, D; Ogurek, S; Liu, X; Zhang, L; Luo, Z; Sakabe, M; Lee, L; Hu, M; Xin, M; Lu, QR. Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumourigenesis. Nature Cell Biology. 2023; 25:323-336.

Luo, Z; Xia, M; Shi, W; Zhao, C; Wang, J; Xin, D; Dong, X; Xiong, Y; Zhang, F; Berry, K; Ma, J; Zhou, W; Taylor, MD; Lu, QR. Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis. Nature. 2022; 612:787-794.

Wang, J; Yang, L; Dong, C; Wang, J; Xu, L; Qiu, Y; Weng, Q; Zhao, C; Xin, M; Lu, QR. EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways. Science Advances. 2020; 6:eaaz6477.

Zhang, L; He, X; Liu, X; Zhang, F; Huang, LF; Potter, AS; Xu, L; Zhou, W; Zheng, T; Luo, Z; Potter, SS; Roussel, MF; Weiss, WA; Lu, QR. Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. Cancer Cell. 2019; 36:302-318.e7.

Weng, Q; Wang, J; Wang, J; He, D; Cheng, Z; Zhang, F; Verma, R; Xu, L; Dong, X; Liao, Y; Waclaw, RR; Potter, SS; Yu, G; Lu, QR. Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis. Cell Stem Cell. 2019; 24:707-723.e8.

He, X; Zhang, L; Queme, LF; Liu, X; Lu, A; Waclaw, RR; Dong, X; Zhou, W; Kidd, G; Yoon, S; Nave, K; Trapp, BD; Jankowski, MP; Lu, QR. A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. Nature Medicine. 2018; 24:338-351.

Lu, F; Chen, Y; Zhao, C; Wang, H; He, D; Xu, L; Wang, J; He, X; Deng, Y; Lu, EE; Bahassi, EM; Canoll, P; Holland, EC; Lu, QR. Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma. Cancer Cell. 2016; 29:669-683.

He, X; Zhang, L; Chen, Y; Remke, M; Shih, D; Lu, F; Wang, H; Deng, Y; Yu, Y; Xia, Y; Hou, Y; Wechsler-Reya, R; Taylor, MD; Lu, QR. The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma. Nature Medicine. 2014; 20:1035-1042.

Yu, Y; Chen, Y; Kim, B; Wang, H; Zhao, C; He, X; Liu, L; Liu, W; Wu, LM N; Mao, M; Chan, JR; Wu, J; Lu, QR. Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell. 2013; 152:248-261.

Liu, X; Xin, DE; Zhong, X; Zhao, C; Li, Z; Zhang, L; Dourson, AJ; Lee, L; Mishra, S; Bayat, AE; Jankowski, MP; Barton, SK; He, X; Lu, QR. Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration. Cell. 2024; 187:2465-2484.e22.

Xin, DE; Liao, Y; Rao, R; Ogurek, S; Sengupta, S; Xin, M; Bayat, AE; Seibel, WL; Graham, RT; Koschmann, C; Lu, QR. Chaetocin-mediated SUV39H1 inhibition targets stemness and oncogenic networks of diffuse midline gliomas and synergizes with ONC201. Neuro-Oncology. 2024; 26:735-748.

Wang, J; Xi, M; Lu, Q; Xia, B; Liu, Y; Yang, J. Single-cell and bulk transcriptomics identifies a tumor-specific CD36+ cancer-associated fibroblast subpopulation in colorectal cancer. Cancer Communications. 2024; 44:495-498.

Koschmann, C; Al-Holou, WN; Alonso, MM; Anastas, J; Bandopadhayay, P; Barron, T; Becher, O; Cartaxo, R; Castro, MG; Chung, C; Yadav, VN; Zhang, X; Zhang, Q; Venneti, S. A road map for the treatment of pediatric diffuse midline glioma. Cancer Cell. 2024; 42:1-5.

Garrett, MC; Albano, R; Carnwath, T; Elahi, L; Behrmann, CA; Pemberton, M; Woo, D; O’Brien, E; VanCauwenbergh, B; Perentesis, J; Roskin, K; Kornblum, H; Plas, DR; Lu, QR. HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma. Scientific Reports. 2023; 13:12433.

Luo, Z; Xin, D; Liao, Y; Berry, K; Ogurek, S; Zhang, F; Zhang, L; Zhao, C; Rao, R; Dong, X; Zhou, W; Weiss, WA; Andreassen, P; Lu, QR. Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability. Nature Communications. 2023; 14:762.

Wang, F; Wang, W; Gu, S; Qi, D; Smith, NA; Peng, W; Dong, W; Yuan, J; Zhao, B; Mao, Y; Shapiro, LA; Yi, SS; Wu, E; Huang, JH. Distinct astrocytic modulatory roles in sensory transmission during sleep, wakefulness, and arousal states in freely moving mice. Nature Communications. 2023; 14:2186.

Talley, MJ; Nardini, D; Ehrman, LA; Lu, QR; Waclaw, RR. Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon. Neural Development. 2023; 18:5.

Fan, C; Wunderlich, M; Cai, X; Yan, Z; Zhang, F; Davis, AK; Xu, L; Guo, F; Lu, QR; Azam, M; Tian, W; Zheng, Y. Kinase-independent role of mTOR and on-/off-target effects of an mTOR kinase inhibitor. Leukemia. 2023; 37:2073-2081.

Xia, B; Liu, Y; Wang, J; Lu, Q; Lv, X; Deng, K; Yang, J. Emerging role of exosome-shuttled noncoding RNAs in gastrointestinal cancers: From intercellular crosstalk to clinical utility. Pharmacological Research. 2023; 195:106880.

Luo, Z; Lu, R. MDB-05. HUMAN FETAL CEREBELLAR CELL ATLAS INFORMS MEDULLOBLASTOMA ORIGIN AND ONCOGENESIS. Neuro-Oncology. 2023; 25:i62.

Lu, R; Luo, Z. MDB-02. NUCLEAR ENVELOPE PHOSPHATASE CTDNEP1 MUTATIONS POTENTIATE AGGRESSIVE MEDULLOBLASTOMA BY TRIGGERING MYC ACTIVATION AND GENOMIC INSTABILITY. Neuro-Oncology. 2023; 25:i61-i62.

Thompson, M; Sakabe, M; Verba, M; Hao, J; Meadows, SM; Lu, QR; Xin, M. PRDM16 regulates arterial development and vascular integrity. Frontiers in Physiology. 2023; 14:1165379.

Zhang, J; Guan, M; Zhou, X; Berry, K; He, X; Lu, QR. Long Noncoding RNAs in CNS Myelination and Disease. The Neuroscientist: reviews at the interface of basic and clinical neurosciences. 2023; 29:287-301.

Verma, R; Chen, X; Xin, D; Luo, Z; Ogurek, S; Xin, M; Rao, R; Berry, K; Lu, QR. Olig1/2-Expressing Intermediate Lineage Progenitors Are Predisposed to PTEN/p53-Loss-Induced Gliomagenesis and Harbor Specific Therapeutic Vulnerabilities. Cancer Research. 2023; 83:890-905.

Hu, X; Wu, X; Berry, K; Zhao, C; Xin, D; Ogurek, S; Liu, X; Zhang, L; Luo, Z; Sakabe, M; Lee, L; Hu, M; Xin, M; Lu, QR. Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumourigenesis. Nature Cell Biology. 2023; 25:323-336.

Luo, Z; Xia, M; Shi, W; Zhao, C; Wang, J; Xin, D; Dong, X; Xiong, Y; Zhang, F; Berry, K; Ma, J; Zhou, W; Taylor, MD; Lu, QR. Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis. Nature. 2022; 612:787-794.

Sakabe, M; Thompson, M; Chen, N; Verba, M; Hassan, A; Lu, R; Xin, M. Inhibition of β1-AR/Gαs signaling promotes cardiomyocyte proliferation in juvenile mice through activation of RhoA-YAP axis. eLife. 2022; 11:e74576.

Garrett, MC; Albano, R; Carnwath, T; Shah, S; Woo, D; Lamba, M; Plas, DR; Paranjpe, A; Roskin, K; Zhao, C; Lu, R. Chromatin structure predicts survival in glioma patients. Scientific Reports. 2022; 12:8221.

Kalim, KW; Yang, JQ; Wunderlich, M; Modur, V; Nguyen, P; Li, Y; Wen, T; Davis, AK; Verma, R; Lu, QR; Jegga, AG; Zheng, Y; Guo, F. Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity. Journal for ImmunoTherapy of Cancer. 2022; 10:e004806.

Intisar, A; Shin, HY; Kim, WH; Kang, HG; Kim, MY; Kim, YS; Cho, Y; Mo, YJ; Lim, H; Lee, S; Lu, QR; Lee, YI; Kim, MS. Implantable Electroceutical Approach Improves Myelination by Restoring Membrane Integrity in a Mouse Model of Peripheral Demyelinating Neuropathy. Advanced Science. 2022; 9:e2201358.

Berry, K; Ogurek, S; Rao, R; Lu, R. TMIC-47. SINGLE-CELL TRANSCRIPTOMICS REVEALS ANTITUMOR IMMUNE RESPONSES OF PROTON TREATMENT IN GLIOBLASTOMA. Neuro-Oncology. 2022; 24:vii281-vii282.

Luo, Z; Lu, R. STEM-24. SINGLE-CELL ATLAS OF HUMAN FETAL CEREBELLUM DECODING MEDULLOBLASTOMA ORIGIN AND ONCOGENESIS. Neuro-Oncology. 2022; 24:vii36.

Wang, J; Yang, L; Jiang, M; Zhao, C; Liu, X; Berry, K; Waisman, A; Langseth, AJ; Novitch, BG; Bergles, DE; Nishiyama, A; Lu, QR. Olig2 Ablation in Immature Oligodendrocytes Does Not Enhance CNS Myelination and Remyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022; 42:8542-8555.

Liao, Y; Luo, Z; Lin, Y; Chen, H; Chen, T; Xu, L; Orgurek, S; Berry, K; Dzieciatkowska, M; Reisz, JA; D’Alessandro, A; Zhou, W; Lu, QR. PRMT3 drives glioblastoma progression by enhancing HIF1A and glycolytic metabolism. Cell Death and Disease. 2022; 13:943.

Wu, LM N; Zhang, F; Rao, R; Adam, M; Pollard, K; Szabo, S; Liu, X; Belcher, KA; Luo, Z; Ogurek, S; Suva, M; Pratilas, CA; Potter, S; Lu, QR. Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy. Science Advances. 2022; 8:eabo5442.

Dong, C; Zhao, C; Chen, X; Berry, K; Wang, J; Zhang, F; Liao, Y; Han, R; Ogurek, S; Xu, L; Campbell, K; Nakafuku, M; Waclaw, RR; Lu, QR. Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022; 42:8373-8392.

Yi, J; Kim, BW; Shi, X; Zhan, X; Lu, QR; Xuan, Z; Wu, J. PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma. Cancer Research. 2022; 82:2874-2886.

Tu, Z; Fan, C; Davis, AK; Hu, M; Wang, C; Dandamudi, A; Seu, KG; Kalfa, TA; Lu, QR; Zheng, Y. Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling. Cell Reports. 2022; 40:111072.

Rao, R; Han, R; Ogurek, S; Xue, C; Wu, LM; Zhang, L; Zhang, L; Hu, J; Phoenix, TN; Waggoner, SN; Lu, QR. Glioblastoma genetic drivers dictate the function of tumor-associated macrophages/microglia and responses to CSF1R inhibition. Neuro-Oncology. 2022; 24:584-597.

Del Águila, Á; Adam, M; Ullom, K; Shaw, N; Qin, S; Ehrman, J; Nardini, D; Salomone, J; Gebelein, B; Lu, QR; Potter, SS; Waclaw, R; Campbell, K; Nakafuku, M. Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice. Development (Cambridge). 2022; 149:dev200028.

Zhang, M; Wang, J; Zhang, K; Lu, G; Liu, Y; Ren, K; Wang, W; Xin, D; Xu, L; Mao, H; Mikoshiba, K; Wu, S; Lu, QR; Zhao, X. Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain. Nature Communications. 2021; 12:5091.

Wargent, ET; Ahmad, SJ S; Lu, QR; Kostenis, E; Arch, JR S; Stocker, CJ. Leanness and Low Plasma Leptin in GPR17 Knockout Mice Are Dependent on Strain and Associated With Increased Energy Intake That Is Not Suppressed by Exogenous Leptin. Frontiers in Endocrinology. 2021; 12:698115.

Guo, D; Wang, Y; Cheng, Y; Liao, S; Hu, J; Du, F; Xu, G; Liu, Y; Cai, KQ; Cheung, M; Wainwright, BJ; Lu, QR; Zhao, Y; Yang, ZJ. Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse. The Journal of Experimental Medicine. 2021; 218:e20202350.

Geraldo, LH; Xu, Y; Jacob, L; Pibouin-Fragner, L; Rao, R; Maissa, N; Verreault, M; Lemaire, N; Knosp, C; Lesaffre, C; Lima, FR S; Thomas, JL; Eichmann, A; Mathivet, T. SLIT2/ROBO signaling in tumor-associated microglia and macrophages drives glioblastoma immunosuppression and vascular dysmorphia. The Journal of Clinical Investigation. 2021; 131:141083.

Tu, Z; Wang, C; Davis, AK; Hu, M; Zhao, C; Xin, M; Lu, QR; Zheng, Y. The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood. 2021; 138:221-233.

Liao, Y; Luo, Z; Deng, Y; Zhang, F; Rao, R; Wang, J; Xu, L; Kumar, SS; Sengupta, S; Dewire-Schottmiller, M; Berry, K; Garrett, M; Fouladi, M; Drissi, R; Lu, QR. OLIG2 maintenance is not essential for diffuse intrinsic pontine glioma cell line growth but regulates tumor phenotypes. Neuro-Oncology. 2021; 23:1183-1196.

Luo, Z; Dong, X; Yu, J; Xia, Y; Berry, KP; Rao, R; Xu, L; Xue, P; Chen, T; Lin, Y; Yu, J; Huang, G; Li, H; Zhou, W; Lu, QR. Genomic and Transcriptomic Analyses Reveals ZNF124 as a Critical Regulator in Highly Aggressive Medulloblastomas. Frontiers in Cell and Developmental Biology. 2021; 9:634056.

Fan, C; Zhao, C; Zhang, F; Kesarwani, M; Tu, Z; Cai, X; Davis, AK; Xu, L; Hochstetler, CL; Chen, X; Azam, M; Tian, W; Lu, QR; Zheng, Y. Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Proceedings of the National Academy of Sciences of USA. 2021; 118:e2020102118.

Wang, J; He, X; Meng, H; Li, Y; Dmitriev, P; Tian, F; Page, JC; Lu, QR; He, Z. Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia. Neuron. 2020; 108:876-886.e4.

Wang, J; Wang, J; Yang, L; Zhao, C; Wu, LN; Xu, L; Zhang, F; Weng, Q; Wegner, M; Lu, QR. CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair. Nature Communications. 2020; 11:4133.

Ueno, M; Nakamura, Y; Nakagawa, H; Niehaus, JK; Maezawa, M; Gu, Z; Kumanogoh, A; Takebayashi, H; Lu, QR; Takada, M; Yoshida, Y. Olig2-Induced Semaphorin Expression Drives Corticospinal Axon Retraction After Spinal Cord Injury. Cerebral Cortex. 2020; 30:5702-5716.

Althoff, MJ; Nayak, RC; Hegde, S; Wellendorf, AM; Bohan, B; Filippi, MD; Xin, M; Richard Lu, Q; Geiger, H; Zheng, Y; Diaz-Meco, MT; Moscat, J; Cancelas, JA. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood. 2020; 136:1824-1836.

Wang, J; Lu, QR. Convergent epigenetic regulation of glial plasticity in myelin repair and brain tumorigenesis: A focus on histone modifying enzymes. Neurobiology of Disease. 2020; 144:105040.

Wang, J; Yang, L; Dong, C; Wang, J; Xu, L; Qiu, Y; Weng, Q; Zhao, C; Xin, M; Lu, QR. EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways. Science Advances. 2020; 6:eaaz6477.

Parras, C; Marie, C; Zhao, C; Lu, QR. Chromatin remodelers in oligodendroglia. Glia. 2020; 68:1604-1618.

Berry, K; Wang, J; Richard Lu, Q. Epigenetic regulation of oligodendrocyte myelination in developmental disorders and neurodegenerative diseases. F1000Research. 2020; 9:f1000 faculty rev-105.

Berry, KP; Lu, QR. Chromatin modification and epigenetic control in functional nerve regeneration. Seminars in Cell and Developmental Biology. 2020; 97:74-83.

Weng, Q; Zhao, M; Zheng, J; Yang, L; Xu, Z; Zhang, Z; Wang, J; Wang, J; Yang, B; Lu, QR; Ying, M; He, Q. STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia. Cell Death and Differentiation. 2020; 27:130-145.