Like most U.S. hospitals, Cincinnati Children's is affected by the IV fluid shortage caused by damage to Baxter International's North Carolina production facility during Hurricane Helene. Our teams will continue to watch this situation and will provide any updates as needed.
Molecular mechanism of hematopoietic stem cell regeneration
Molecular mechanism of hematopoietic stem cell regeneration
The hematopoietic system is organized in a hierarchical manner. Hematopoietic stem cells reside at the top of the hematopoietic system and give rise to all mature blood and immune cells through a hierarchical process of cell lineage commitment. HSCs also have the ability of regenerating themselves through so-called self-renewal. The key functional outcome of these characteristics is that life-long multipotent self-renewing HSCs give rise to long term multilineage repopulation in transplantation settings. Hematopoiesis takes place in the bone marrow and is regulated by both intrinsic and extrinsic factors. A major interest in the lab is to identify what these factors are, and to investigate how they contribute to HSC regulation.
