FANCD2 – Related Projects

Regulation of FANCD2 monoubiquitination by the ATR checkpoint kinase and relationship to DNA replication.

Regulation by ATR suggests a possible function of FA proteins at the replication fork, which we are continuing to investigate to better understand the role of monoubiquitinated FANCD2 in the maintenance of genome stability. 

Regulation and function of monoubiquitinated FANCD2 in chromatin.

FANCD2 assembles into foci in chromatin, including our finding of an association with telomeres, a specialized heterochromatin structure, in cells that employ alternative lengthening of telomeres. Ongoing work seeks to better understand the function of FA proteins in chromatin with or without exogenous DNA damage.