Tchieu Lab

Publications

Peter, J; Caldwell, KC N; McClain, L; Tchieu, J; Ross, AE; Luo, Y. Inhibition of PTPRS function does not affect the survival or regeneration of dopaminergic neurons but alters synaptic function in the nigrostriatal pathway. Neurobiology of Disease. 2025; 213:107023.

Miao, Y; Pek, NM; Tan, C; Jiang, C; Yu, Z; Iwasawa, K; Shi, M; Kechele, DO; Sundaram, N; Pastrana-Gomez, V; Zorn, AM; Chen, YW; Guo, M; Gu, M. Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids. Cell. 2025; 188:4295-4313.e27.

Cai, H; Tian, C; Chen, L; Yang, Y; Sun, AX; McCracken, K; Tchieu, J; Gu, M; Mackie, K; Guo, F. Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids. Cell Stem Cell. 2025; 32:824-837.e5.

Cederquist, GY; Oberst, P; Chang, X; Tchieu, J; Studer, L. Generation of Prefrontal Cortex Neurons from Human Pluripotent Stem Cells Under Chemically Defined Conditions. Synapse Development. : Springer US; Springer US; 2025.

Tschuck, J; Padmanabhan Nair, V; Galhoz, A; Zaratiegui, C; Tai, HM; Ciceri, G; Rothenaigner, I; Tchieu, J; Stockwell, BR; Studer, L; Cabianca, DS; Menden, MP; Vincendeau, M; Hadian, K. Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development. Nature Communications. 2024; 15:7611.

Gu, L; Cai, H; Chen, L; Gu, M; Tchieu, J; Guo, F. Functional Neural Networks in Human Brain Organoids. BME Frontiers. 2024; 5:0065.

Liu, X; Xin, DE; Zhong, X; Zhao, C; Li, Z; Zhang, L; Dourson, AJ; Lee, L; Mishra, S; Bayat, AE; Jankowski, MP; Barton, SK; He, X; Lu, QR. Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration. Cell. 2024; 187:2465-2484.e22.

Cai, H; Ao, Z; Tian, C; Wu, Z; Liu, H; Tchieu, J; Gu, M; Mackie, K; Guo, F. Brain organoid reservoir computing for artificial intelligence. Nature Electronics. 2023; 6:1032-1039.

Majd, H; Amin, S; Ghazizadeh, Z; Cesiulis, A; Arroyo, E; Lankford, K; Majd, A; Farahvashi, S; Chemel, AK; Okoye, M; Kocsis, JD; Chen, S; Studer, L; Fattahi, F. Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy. Cell Stem Cell. 2023; 30:632-647.e10.

Verrall, CE; Patel, S; Travitz, L; Tchieu, J; Dale, RC; Kasparian, NA; Winlaw, DS; Blue, GM. Biological and structural phenotypes associated with neurodevelopmental outcomes in congenital heart disease. Translational Pediatrics. 2023; 12:768-786.

Chang, X; Gu, M; Tchieu, J. Harnessing the Power of Stem Cell Models to Study Shared Genetic Variants in Congenital Heart Diseases and Neurodevelopmental Disorders. Cells. 2022; 11:460.

Padmanabhan Nair, V; Liu, H; Ciceri, G; Jungverdorben, J; Frishman, G; Tchieu, J; Cederquist, GY; Rothenaigner, I; Schorpp, K; Klepper, L; Hadian, K; Frishman, D; Studer, L; Vincendeau, M. Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3. Cell Stem Cell. 2021; 28:1566-1581.e8.

Deng, X; Tchieu, J; Higginson, DS; Hsu, KS; Feldman, R; Studer, L; Shaham, S; Powell, SN; Fuks, Z; Kolesnick, R. Disabling the Fanconi Anemia Pathway in Stem Cells Leads to Radioresistance and Genomic Instability. Cancer Research. 2021; 81:3706-3716.

Guttikonda, SR; Sikkema, L; Tchieu, J; Saurat, N; Walsh, RM; Harschnitz, O; Ciceri, G; Sneeboer, M; Mazutis, L; Setty, M; Zumbo, P; Betel, D; de Witte, LD; Pe’er, D; Studer, L. Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer's disease. Nature Neuroscience. 2021; 24:343-354.