Kopan Lab

Publications

Swaminathan, B; Youn, SW; Naiche, LA; Du, J; Villa, SR; Metz, JB; Feng, H; Zhang, C; Kopan, R; Sims, PA; Kitajewski, JK. Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration. Scientific Reports. 2022; 12:1655.

Duvall, K; Crist, L; Perl, AJ; Shakked, NP; Chaturvedi, P; Kopan, R. Revisiting the role of Notch in nephron segmentation confirms a role for proximal fate selection during mouse and human nephrogenesis. Development (Cambridge). 2022; 149:dev200446.

Murrison, LB; Ren, X; Preusse, K; He, H; Kroner, J; Chen, X; Jenkins, S; Johansson, E; Biagini, JM; Weirauch, MT; Kopan, R; Martin, LJ; Khurana Hershey, GK. TSLP disease-associated genetic variants combined with airway TSLP expression influence asthma risk. Journal of Allergy and Clinical Immunology. 2022; 149:79-88.

Jarmas, AE; Brunskill, EW; Chaturvedi, P; Salomonis, N; Kopan, R. Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis. Nature Communications. 2021; 12:6332.

Kuang, Y; Pyo, A; Eafergan, N; Cain, B; Gutzwiller, LM; Axelrod, O; Gagliani, EK; Weirauch, MT; Kopan, R; Kovall, RA; Sprinzak, D; Gebelein, B. Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor. Editor, Aster JC. PLoS Genetics. 2021; 17:e1009039.

Makayes, Y; Resnick, E; Hinden, L; Aizenshtein, E; Shlomi, T; Kopan, R; Nechama, M; Volovelsky, O. Increasing mTORC1 Pathway Activity or Methionine Supplementation during Pregnancy Reverses the Negative Effect of Maternal Malnutrition on the Developing Kidney. Journal of the American Society of Nephrology : JASN. 2021; 32:1898-1912.

Hass, MR; Brissette, D; Parameswaran, S; Pujato, M; Donmez, O; Kottyan, LC; Weirauch, MT; Kopan, R. Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets. Editor, Greally JM. PLoS Genetics. 2021; 17:e1009574.

Schuh, MP; Alkhudairy, L; Potter, A; Potter, SS; Chetal, K; Thakkar, K; Salomonis, N; Kopan, R. The Rhesus Macaque Serves As a Model for Human Lateral Branch Nephrogenesis. Journal of the American Society of Nephrology : JASN. 2021; 32:1097-1112.

Kobia, FM; Preusse, K; Dai, Q; Weaver, N; Hass, MR; Chaturvedi, P; Stein, SJ; Pear, WS; Yuan, Z; Kovall, RA; Sprinzak, D; Gebelein, B; Brunskill, EW; Kopan, R. Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation. Editor, Koo B-K. PLoS biology. 2020; 18:e3000850.

Mukherjeel, M; Ratnayake, I; Janga, M; Fogarty, E; Scheidt, S; Grassmeyer, J; DeRiso, J; Chandrasekar, I; Ahrenkiel, SP; Kopan, R; Surendran, K. Notch signaling regulates Akap12 expression and primary cilia length during renal tubule morphogenesis. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020; 34:9512-9530.

Kuang, Y; Golan, O; Preusse, K; Cain, B; Christensen, CJ; Salomone, J; Campbell, I; Okwubido-Williams, FV; Hass, MR; Yuan, Z; Kovall, RA; Kopan, R; Sprinzak, D; Gebelein, B. Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism. eLife. 2020; 9:e53659.

Seymour, PA; Collin, CA; Egeskov-Madsen, AL R; Jorgensen, MC; Shimojo, H; Imayoshi, I; de Lichtenberg, KH; Kopan, R; Kageyama, R; Serup, P. Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors. Developmental Cell. 2020; 52:731-747.e8.