Gebelein Lab

Publications

Salomone, J; Farrow, E; Gebelein, B. Homeodomain complex formation and biomolecular condensates in Hox gene regulation. Seminars in Cell and Developmental Biology. 2024; 152-153:93-100.

Cain, B; Webb, J; Yuan, Z; Cheung, D; Lim, HW; Kovall, RA; Weirauch, MT; Gebelein, B. Prediction of cooperative homeodomain DNA binding sites from high-throughput-SELEX data. Nucleic Acids Research. 2023; 51:6055-6072.

Gagliani, EK; Gutzwiller, LM; Kuang, Y; Odaka, Y; Hoffmeister, P; Hauff, S; Turkiewicz, A; Harding-Theobald, E; Dolph, PJ; Borggrefe, T; Oswald, F; Gebelein, B; Kovall, RA. A Drosophila Su(H) model of Adams-Oliver Syndrome reveals cofactor titration as a mechanism underlying developmental defects. Editor, Wappner P. PLoS Genetics. 2022; 18:e1010335.

Del Águila, Á; Adam, M; Ullom, K; Shaw, N; Qin, S; Ehrman, J; Nardini, D; Salomone, J; Gebelein, B; Lu, QR; Potter, SS; Waclaw, R; Campbell, K; Nakafuku, M. Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice. Development (Cambridge). 2022; 149:dev200028.

Neilson, DE; Zech, M; Hufnagel, RB; Slone, J; Wang, X; Homan, S; Gutzwiller, LM; Leslie, EJ; Leslie, ND; Xiao, J; Eckenweiler, M; Winkelmann, J; Gilbert, DL; Huang, T. A Novel Variant of ATP5MC3 Associated with Both Dystonia and Spastic Paraplegia. Movement Disorders. 2022; 37:375-383.

Cain, B; Gebelein, B. Mechanisms Underlying Hox-Mediated Transcriptional Outcomes. Frontiers in Cell and Developmental Biology. 2021; 9:787339.

Kuang, Y; Pyo, A; Eafergan, N; Cain, B; Gutzwiller, LM; Axelrod, O; Gagliani, EK; Weirauch, MT; Kopan, R; Kovall, RA; Sprinzak, D; Gebelein, B. Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor. Editor, Aster JC. PLoS Genetics. 2021; 17:e1009039.

Oatman, N; Dasgupta, N; Arora, P; Choi, K; Gawali, MV; Gupta, N; Parameswaran, S; Salomone, J; Reisz, JA; Lawler, S; Weirauch, MT; D'Alessandro, A; Komurov, K; Dasgupta, B. Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer. Science Advances. 2021; 7:eabd7459.

Salomone, J; Qin, S; Fufa, TD; Cain, B; Farrow, E; Guan, B; Hufnagel, RB; Nakafuku, M; Lim, HW; Campbell, K; Gebelein, B. Conserved Gsx2/Ind homeodomain monomer versus homodimer DNA binding defines regulatory outcomes in flies and mice. Genes and Development. 2021; 35:157-174.

Kobia, FM; Preusse, K; Dai, Q; Weaver, N; Hass, MR; Chaturvedi, P; Stein, SJ; Pear, WS; Yuan, Z; Kovall, RA; Sprinzak, D; Gebelein, B; Brunskill, EW; Kopan, R. Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation. Editor, Koo B-K. PLoS biology. 2020; 18:e3000850.

Elliott, KH; Chen, X; Salomone, J; Chaturvedi, P; Schultz, PA; Balchand, SK; Servetas, JD; Zuniga, A; Zeller, R; Gebelein, B; Weirauch, MT; Peterson, KA; Brugmann, SA. Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks. eLife. 2020; 9:e56450.

Kuang, Y; Golan, O; Preusse, K; Cain, B; Christensen, CJ; Salomone, J; Campbell, I; Okwubido-Williams, FV; Hass, MR; Yuan, Z; Kovall, RA; Kopan, R; Sprinzak, D; Gebelein, B. Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism. eLife. 2020; 9:e53659.

Roychoudhury, K; Salomone, J; Qin, S; Cain, B; Adam, M; Pottert, SS; Nakafuku, M; Gebelein, B; Campbell, K. Physical interactions between Gsx2 and Ascl1 balance progenitor expansion versus neurogenesis in the mouse lateral ganglionic eminence. Development (Cambridge). 2020; 147:dev185348.