Publications

Shao TY, Jiang TT, Stevens J, Russi AE, Troutman TD, Bernieh A, Pham G, Erickson JJ, Eshleman EM, Alenghat T, Jameson SC, Hogquist KA, Weaver CT, Haslam DB, Deshmukh H, Way SS. Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation. Cell Rep. 2023 Nov 28;42(11):113323. doi: 10.1016/j.celrep.2023.113323. Epub 2023 Oct 26. PMID: 37889750; PMCID: PMC10822050.

Wilburn AN, McAlees JW, Haslam DB, Graspeuntner S, Schmudde I, Laumonnier Y, Rupp J, Chougnet CA, Deshmukh H, Zacharias WJ, König P, Lewkowich IP. Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice. Am J Respir Cell Mol Biol. 2023 May;68(5):498-510. doi: 10.1165/rcmb.2022-0367OC. PMID: 36622830; PMCID: PMC10174167.

Shao TY, Kinder JM, Harper G, Pham G, Peng Y, Liu J, Gregory EJ, Sherman BE, Wu Y, Iten AE, Hu YC, Russi AE, Erickson JJ, Miller-Handley H, Way SS. Reproductive outcomes after pregnancy-induced displacement of preexisting microchimeric cells. Science. 2023 Sep 22;381(6664):1324-1330. doi: 10.1126/science.adf9325. Epub 2023 Sep 21. PMID: 37733857.

Eshleman EM, Shao TY, Woo V, Rice T, Engleman L, Didriksen BJ, Whitt J, Haslam DB, Way SS, Alenghat T. Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity. J Clin Invest. 2023 Feb 15;133(4):e162190. doi: 10.1172/JCI162190. PMID: 36602872; PMCID: PMC9927950.

Abu-Raya B, Esser MJ, Nakabembe E, Reiné J, Amaral K, Diks AM, Imede E, Way SS, Harandi AM, Gorringe A, Le Doare K, Halperin SA, Berkowska MA, Sadarangani M. Antibody and B-cell Immune Responses Against Bordetella Pertussis Following Infection and Immunization. J Mol Biol. 2023 Dec 15;435(24):168344. doi: 10.1016/j.jmb.2023.168344. Epub 2023 Nov 4. PMID: 37926426.

Giles ML, Way SS, Marchant A, Aghaepour N, James T, Schaltz-Buchholzer F, Zazara D, Arck P, Kollmann TR. Maternal Vaccination to Prevent Adverse Pregnancy Outcomes: An Underutilized Molecular Immunological Intervention? J Mol Biol. 2023 Jul 1;435(13):168097. doi: 10.1016/j.jmb.2023.168097. Epub 2023 Apr 18. PMID: 37080422.

Choi Y, Lichterman JN, Coughlin LA, Poulides N, Li W, Del Valle P, Palmer SN, Gan S, Kim J, Zhan X, Gao Y, Evers BM, Hooper LV, Pasare C, Koh AY. Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity. Sci Immunol. 2023 Mar 10;8(81):eabo2003. doi: 10.1126/sciimmunol.abo2003. Epub 2023 Mar 3. PMID: 36867675; PMCID: PMC10080670.

Overcast GR, Meibers HE, Eshleman EM, Saha I, Waggoner L, Patel KN, Jain VG, Haslam DB, Alenghat T, VanDussen KL, Pasare C. IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation. J Exp Med. 2023 Jun 5;220(6):e20212523. doi: 10.1084/jem.20212523. Epub 2023 Mar 28. PMID: 36976181; PMCID: PMC10067527.

Meibers HE, Warrick KA, VonHandorf A, Vallez CN, Kawarizadeh K, Saha I, Donmez O, Jain VG, Kottyan LC, Weirauch MT, Pasare C. Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells. Cell Rep. 2023 Oct 31;42(10):113180. doi: 10.1016/j.celrep.2023.113180. Epub 2023 Oct 3. PMID: 37794597; PMCID: PMC10654673.

Bennett H, Troutman TD, Zhou E, Spann NJ, Link VM, Seidman JS, Nickl CK, Abe Y, Sakai M, Pasillas MP, Marlman JM, Guzman C, Hosseini M, Schnabl B, Glass CK. Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes. Nat Immunol. 2023 Nov;24(11):1825-1838. doi: 10.1038/s41590-023-01631-w. Epub 2023 Sep 21. PMID: 37735593; PMCID: PMC10602851.

Arimoto KI, Miyauchi S, Troutman TD, Zhang Y, Liu M, Stoner SA, Davis AG, Fan JB, Huang YJ, Yan M, Glass CK, Zhang DE. Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis. Nat Commun. 2023 Jan 17;14(1):251. doi: 10.1038/s41467-022-35348-5. PMID: 36646704; PMCID: PMC9842760.

Steele H, Cheng J, Willicut A, Dell G, Breckenridge J, Culberson E, Ghastine A, Tardif V, Herro R. TNF superfamily control of tissue remodeling and fibrosis. Front Immunol. 2023 Jul 3;14:1219907. doi: 10.3389/fimmu.2023.1219907. PMID: 37465675; PMCID: PMC10351606.

Miki H, Kiosses WB, Manresa MC, Gupta RK, Sethi GS, Herro R, Da Silva Antunes R, Dutta P, Miller M, Fung K, Chawla A, Dobaczewska K, Ay F, Broide DH, Tumanov AV, Croft M. Lymphotoxin beta receptor signaling directly controls airway smooth muscle deregulation and asthmatic lung dysfunction. J Allergy Clin Immunol. 2023 Apr;151(4):976-990.e5. doi: 10.1016/j.jaci.2022.11.016. Epub 2022 Dec 5. PMID: 36473503; PMCID: PMC10081945.

Overcast GR, Meibers HE, Eshleman EM, Saha I, Waggoner L, Patel KN, Jain VG, Haslam DB, Alenghat T, VanDussen KL, Pasare C. IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation. J Exp Med. 2023 Jun 5;220(6):e20212523. doi: 10.1084/jem.20212523. Epub 2023 Mar 28. PMID: 36976181; PMCID: PMC10067527.

Eshleman EM, Alenghat T. Cleaving an epithelial path to food tolerance. Cell Res. 2023 Dec;33(12):896-897. doi: 10.1038/s41422-023-00856-6. PMID: 37491601; PMCID: PMC10709587.

Velez Lopez A, Waddell A, Antonacci S, Castillo D, Santucci N, Ollberding NJ, Eshleman EM, Denson LA, Alenghat T. Microbiota-derived butyrate dampens linaclotide stimulation of the guanylate cyclase C pathway in patient-derived colonoids. Neurogastroenterol Motil. 2023 Dec;35(12):e14681. doi: 10.1111/nmo.14681. Epub 2023 Sep 22. PMID: 37736865; PMCID: PMC10841278.

Kharofa J, Apewokin S, Alenghat T, Ollberding NJ. Metagenomic analysis of the fecal microbiome in colorectal cancer patients compared to healthy controls as a function of age. Cancer Med. 2023 Feb;12(3):2945-2957. doi: 10.1002/cam4.5197. Epub 2022 Sep 3. PMID: 36056757; PMCID: PMC9939174.

Sawada K, Chung H, Softic S, Moreno-Fernandez ME, Divanovic S. The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease. Cell Metab. 2023 Nov 7;35(11):1852-1871. doi: 10.1016/j.cmet.2023.10.009. PMID: 37939656; PMCID: PMC10680147.

Doll JR, Moreno-Fernandez ME, Stankiewicz TE, Wayland JL, Wilburn A, Weinhaus B, Chougnet CA, Giordano D, Cappelletti M, Presicce P, Kallapur SG, Salomonis N, Tilburgs T, Divanovic S. BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth. Cell Rep. 2023 Apr 25;42(4):112352. doi: 10.1016/j.celrep.2023.112352. Epub 2023 Apr 5. PMID: 37027297; PMCID: PMC10551044.

Park SH, Helsley RN, Fadhul T, Willoughby JLS, Noetzli L, Tu HC, Solheim MH, Fujisaka S, Pan H, Dreyfuss JM, Bons J, Rose J, King CD, Schilling B, Lusis AJ, Pan C, Gupta M, Kulkarni RN, Fitzgerald K, Kern PA, Divanovic S, Kahn CR, Softic S. Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD. Metabolism. 2023 Aug;145:155591. doi: 10.1016/j.metabol.2023.155591. Epub 2023 May 23. PMID: 37230214; PMCID: PMC10752375.

Oates JR, Sawada K, Giles DA, Alarcon PC, Damen MSMA, Szabo S, Stankiewicz TE, Moreno-Fernandez ME, Divanovic S. Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease. Front Immunol. 2023 Feb 17;14:1095132. doi: 10.3389/fimmu.2023.1095132. PMID: 36875069; PMCID: PMC9982161.

Alarcon PC, Damen MSMA, Ulanowicz CJ, Sawada K, Oates JR, Toth A, Wayland JL, Chung H, Stankiewicz TE, Moreno-Fernandez ME, Szabo S, Zacharias WJ, Divanovic S. Obesity amplifies influenza virus-driven disease severity in male and female mice. Mucosal Immunol. 2023 Dec;16(6):843-858. doi: 10.1016/j.mucimm.2023.09.004. Epub 2023 Sep 18. PMID: 37730122; PMCID: PMC10842771.

Wayland JL, Doll JR, Lawson MJ, Stankiewicz TE, Oates JR, Sawada K, Damen MSMA, Alarcon PC, Haslam DB, Trout AT, DeFranco EA, Klepper CM, Woo JG, Moreno-Fernandez ME, Mouzaki M, Divanovic S. Thermoneutral Housing Enables Studies of Vertical Transmission of Obesogenic Diet-Driven Metabolic Diseases. Nutrients. 2023 Nov 29;15(23):4958. doi: 10.3390/nu15234958. PMID: 38068816; PMCID: PMC10708424.

Wayland JL, Stemen EL, Doll JR, Divanovic S. Protocol for cytokine and uterine immune cell characterization in a mouse model of LPS-induced preterm birth. STAR Protoc. 2023 Oct 18;4(4):102643. doi: 10.1016/j.xpro.2023.102643. Epub ahead of print. PMID: 37858473; PMCID: PMC10594632.

Bewersdorf JP, Xie Z, Bejar R, Borate U, Boultwood J, Brunner AM, Buckstein R, Carraway HE, Churpek JE, Daver NG, Porta MGD, DeZern AE, Fenaux P, Figueroa ME, Gore SD, Griffiths EA, Halene S, Hasserjian RP, Hourigan CS, Kim TK, Komrokji R, Kuchroo VK, List AF, Loghavi S, Majeti R, Odenike O, Patnaik MM, Platzbecker U, Roboz GJ, Sallman DA, Santini V, Sanz G, Sekeres MA, Stahl M, Starczynowski DT, Steensma DP, Taylor J, Abdel-Wahab O, Xu ML, Savona MR, Wei AH, Zeidan AM. Current landscape of translational and clinical research in myelodysplastic syndromes/neoplasms (MDS): Proceedings from the 1st International Workshop on MDS (iwMDS) Of the International Consortium for MDS (icMDS). Blood Rev. 2023 Jul;60:101072. doi: 10.1016/j.blre.2023.101072. Epub 2023 Mar 11. PMID: 36934059.

Xie Z, Starczynowski DT. Are DDX41 variants of unknown significance and pathogenic variants created equal? Haematologica. 2023 Nov 1;108(11):2883-2885. doi: 10.3324/haematol.2023.283416. PMID: 37317927; PMCID: PMC10620556.

Marion W, Koppe T, Chen CC, Wang D, Frenis K, Fierstein S, Sensharma P, Aumais O, Peters M, Ruiz-Torres S, Chihanga T, Boettcher S, Shimamura A, Bauer DE, Schlaeger T, Wells SI, Ebert BL, Starczynowski D, da Rocha EL, Rowe RG. RUNX1 mutations mitigate quiescence to promote transformation of hematopoietic progenitors in Fanconi anemia. Leukemia. 2023 Aug;37(8):1698-1708. doi: 10.1038/s41375-023-01945-6. Epub 2023 Jun 30. PMID: 37391485.

Stahl M, Bewersdorf JP, Xie Z, Porta MGD, Komrokji R, Xu ML, Abdel-Wahab O, Taylor J, Steensma DP, Starczynowski DT, Sekeres MA, Sanz G, Sallman DA, Roboz GJ, Platzbecker U, Patnaik MM, Padron E, Odenike O, Nimer SD, Nazha A, Majeti R, Loghavi S, Little RF, List AF, Kim TK, Hourigan CS, Hasserjian RP, Halene S, Griffiths EA, Gore SD, Greenberg P, Figueroa ME, Fenaux P, Efficace F, DeZern AE, Daver NG, Churpek JE, Carraway HE, Buckstein R, Brunner AM, Boultwood J, Borate U, Bejar R, Bennett JM, Wei AH, Santini V, Savona MR, Zeidan AM. Classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): A state-of-the-art report on behalf of the International Consortium for MDS (icMDS). Blood Rev. 2023 Nov;62:101128. doi: 10.1016/j.blre.2023.101128. Epub 2023 Aug 19. PMID: 37704469.

Bennett J, Ishikawa C, Agarwal P, Yeung J, Sampson A, Uible E, Vick E, Bolanos LC, Hueneman K, Wunderlich M, Kolt A, Choi K, Volk A, Greis KD, Rosenbaum J, Hoyt SB, Thomas CJ, Starczynowski DT. Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML. Blood. 2023 Sep 14;142(11):989-1007. doi: 10.1182/blood.2022018718. PMID: 37172199; PMCID: PMC10517216.

Riabov V, Xu Q, Schmitt N, Streuer A, Ge G, Bolanos L, Wunderlich M, Jann JC, Wein A, Altrock E, Demmerle M, Mukherjee S, Ali AM, Rapp F, Nowak V, Weimer N, Obländer J, Palme I, Göl M, Jawhar A, Darwich A, Wuchter P, Weiss C, Raza A, Foulks JM, Starczynowski DT, Yang FC, Metzgeroth G, Steiner L, Jawhar M, Hofmann WK, Nowak D. ASXL1 mutations are associated with a response to alvocidib and 5-azacytidine combination in myelodysplastic neoplasms. Haematologica. 2023 Nov 2. doi: 10.3324/haematol.2023.282921. Epub ahead of print. PMID: 37916386.

Gorak EJ, Otterstatter M, Al Baghdadi T, Gillis N, Foran JM, Liu JJ, Bejar R, Gore SD, Kroft SH, Harrington A, Saber W, Starczynowski D, Rollison DE, Zhang L, Moscinski L, Wilson S, Thompson J, Borchert C, Sherman S, Hebert D, Walker ME, Padron E, DeZern AE, Sekeres MA. Discordant pathologic diagnoses of myelodysplastic neoplasms and their implications for registries and therapies. Blood Adv. 2023 Oct 24;7(20):6120-6129. doi: 10.1182/bloodadvances.2023010061. PMID: 37552083; PMCID: PMC10582385.

Dean ST, Ishikawa C, Zhu X, Walulik S, Nixon T, Jordan JK, Henderson S, Wyder M, Salomonis N, Wunderlich M, Greis KD, Starczynowski DT, Volk AG. Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development. Blood Adv. 2023 Sep 12;7(17):4822-4837. doi: 10.1182/bloodadvances.2022009438. PMID: 37205848; PMCID: PMC10469560.

Stahl M, Abdel-Wahab O, Wei AH, Savona MR, Xu ML, Xie Z, Taylor J, Starczynowski D, Sanz GF, Sallman DA, Santini V, Roboz GJ, Patnaik MM, Padron E, Odenike O, Nazha A, Nimer SD, Majeti R, Little RF, Gore S, List AF, Kutchroo V, Komrokji RS, Kim TK, Kim N, Hourigan CS, Hasserjian RP, Halene S, Griffiths EA, Greenberg PL, Figueroa M, Fenaux P, Efficace F, DeZern AE, Della Porta MG, Daver NG, Churpek JE, Carraway HE, Brunner AM, Borate U, Bennett JM, Bejar R, Boultwood J, Loghavi S, Bewersdorf JP, Platzbecker U, Steensma DP, Sekeres MA, Buckstein RJ, Zeidan AM. An agenda to advance research in myelodysplastic syndromes: a TOP 10 priority list from the first international workshop in MDS. Blood Adv. 2023 Jun 27;7(12):2709-2714. doi: 10.1182/bloodadvances.2022008747. PMID: 36260702; PMCID: PMC10333740.

Muto T, Walker CS, Agarwal P, Vick E, Sampson A, Choi K, Niederkorn M, Ishikawa C, Hueneman K, Varney M, Starczynowski DT. Inactivation of p53 provides a competitive advantage to del(5q) myelodysplastic syndrome hematopoietic stem cells during inflammation. Haematologica. 2023 Oct 1;108(10):2715-2729. doi: 10.3324/haematol.2022.282349. PMID: 37102608; PMCID: PMC10542836.

Ikumi NM, Koenig Z, Mahajan S, Gray CM, Tilburgs T. Purification of primary human placental leukocytes to study maternal-fetal interactions. STAR Protoc. 2023 May 12;4(2):102277. doi: 10.1016/j.xpro.2023.102277. Epub ahead of print. PMID: 37182206; PMCID: PMC10199256.

Hamilton I, Ikumi NM, Kshirsagar S, Goodman WA, Tilburgs T. Utilizing primary HLA-G+ extravillous trophoblasts and HLA-G+ EVT-like cell lines to study maternal-fetal interactions. STAR Protoc. 2023 May 11;4(2):102276. doi: 10.1016/j.xpro.2023.102276. Epub ahead of print. PMID: 37178111; PMCID: PMC10200998.

Mahajan S, Alexander A, Koenig Z, Saba N, Prasanphanich N, Hildeman DA, Chougnet CA, DeFranco E, Andorf S, Tilburgs T. Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells. JCI Insight. 2023 Sep 8;8(17):e171806. doi: 10.1172/jci.insight.171806. PMID: 37681414; PMCID: PMC10544202.

Ando S, Perkins CM, Sajiki Y, Chastain C, Valanparambil RM, Wieland A, Hudson WH, Hashimoto M, Ramalingam SS, Freeman GJ, Ahmed R, Araki K. mTOR regulates T cell exhaustion and PD-1-targeted immunotherapy response during chronic viral infection. J Clin Invest. 2023 Jan 17;133(2):e160025. doi: 10.1172/JCI160025. PMID: 36378537; PMCID: PMC9843061.

Gill AL, Wang PH, Lee J, Hudson WH, Ando S, Araki K, Hu Y, Wieland A, Im S, Gavora A, Medina CB, Freeman GJ, Hashimoto M, Reiner SL, Ahmed R. PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors. Sci Immunol. 2023 Aug 4;8(86):eadg0539. doi: 10.1126/sciimmunol.adg0539. Epub 2023 Aug 25. PMID: 37624909; PMCID: PMC10798572.

Chen C, Zheng H, Horwitz EM, Ando S, Araki K, Zhao P, Li Z, Ford ML, Ahmed R, Qu CK. Mitochondrial metabolic flexibility is critical for CD8+ T cell antitumor immunity. Sci Adv. 2023 Dec 8;9(49):eadf9522. doi: 10.1126/sciadv.adf9522. Epub 2023 Dec 6. PMID: 38055827; PMCID: PMC10699783.

Parks OB, Eddens T, Sojati J, Lan J, Zhang Y, Oury TD, Ramsey M, Erickson JJ, Byersdorfer CA, Williams JV. Terminally exhausted CD8+ T cells contribute to age-dependent severity of respiratory virus infection. Immun Ageing. 2023 Aug 1;20(1):40. doi: 10.1186/s12979-023-00365-5. PMID: 37528458; PMCID: PMC10391960.

Parks OB, Antos D, Eddens T, Walters S, Johnson M, Oury TD, Gottschalk RA, Erickson JJ, Williams JV. PD-1 Impairs CD8+ T Cell Granzyme B Production in Aged Mice during Acute Viral Respiratory Infection. Immunohorizons. 2023 Nov 1;7(11):771-787. doi: 10.4049/immunohorizons.2300094. PMID: 38015461; PMCID: PMC10696419.