Rothenberg CURED Lab
Rothenberg CURED Lab

Best of Our Research

Publications from the Rothenberg Lab

These journal article publications are the culmination of our research projects, steps forward in our understanding of biological and diseases processes, a sharing of our findings with others, and a basis for further research. 

These steps forward would not be possible without the generous support of many foundations and agencies, such as the Campaign Urging Research for Eosinophilic Disease (CURED) and the National Institutes of Health (NIH). 

Publications

Kliewer, KL; Murray-Petzold, C; Collins, MH; Abonia, JP; Bolton, SM; DiTommaso, LA; Martin, LJ; Zhang, X; Mukkada, VA; Putnam, PE; Lyles, JL; Shoda, T; Klion, AD; Rothenberg, ME. Benralizumab for eosinophilic gastritis: a single-site, randomised, double-blind, placebo-controlled, phase 2 trial. The Lancet Gastroenterology and Hepatology. 2023; 8:803-815.

Kliewer, KL; Gonsalves, N; Dellon, ES; Katzka, DA; Abonia, JP; Aceves, SS; Arva, NC; Besse, JA; Bonis, PA; Caldwell, JM; Yang, GY; Zhang, X; Furuta, GT; Rothenberg, ME. One-food versus six-food elimination diet therapy for the treatment of eosinophilic oesophagitis: a multicentre, randomised, open-label trial. The Lancet Gastroenterology and Hepatology. 2023; 8:408-421.

Dellon, ES; Rothenberg, ME; Collins, MH; Hirano, I; Chehade, M; Bredenoord, AJ; Lucendo, AJ; Spergel, JM; Aceves, S; Sun, X; Shumel, B; Maloney, J; Giannelou, A; Shabbir, A. Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis. The New England Journal of Medicine. 2022; 387:2317-2330.

Shoda, T; Kaufman, KM; Wen, T; Caldwell, JM; Osswald, GA; Purnima, P; Zimmermann, N; Collins, MH; Rehn, K; Foote, H; Mukkada, VA; Putnam, PE; Martin, LJ; Rothenberg, ME. Desmoplakin and periplakin genetically and functionally contribute to eosinophilic esophagitis. Nature Communications. 2021; 12:6795.

Brusilovsky, M; Rochman, M; Rochman, Y; Caldwell, JM; Mack, LE; Felton, JM; Habel, JE; Porollo, A; Pasare, C; Rothenberg, ME. Environmental allergens trigger type 2 inflammation through ripoptosome activation. Nature Immunology. 2021; 22:1316-1326.

Azouz, NP; Klingler, AM; Pathre, P; Besse, JA; Ben Baruch-Morgenstern, N; Ballaban, AY; Osswald, GA; Brusilovsky, M; Habel, JE; Caldwell, JM; Ynga-Durand, MA; Abonia, PJ; Hu, Y; Wen, T; Rothenberg, ME. Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis. Science Translational Medicine. 2020; 12.

Wen, T; Aronow, BJ; Rochman, Y; Rochman, M; Kiran, KC; Dexheimer, PJ; Putnam, P; Mukkada, V; Foote, H; Rehn, K; Darko, S; Douek, D; Rothenberg, ME. Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis. The Journal of Clinical Investigation. 2019; 129:2014-2028.

Kottyan, LC; Davis, BP; Sherrill, JD; Liu, K; Rochman, M; Kaufman, K; Weirauch, MT; Vaughn, S; Lazaro, S; Rupert, AM; Abonia, JP; Martin, LJ; Harley, JB; Rothenberg, ME. Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease. Nature Genetics. 2014; 46:895-900.

Rothenberg, ME; Klion, AD; Roufosse, FE; Kahn, JE; Weller, PF; Simon, H; Schwartz, LB; Rosenwasser, LJ; Ring, J; Griffin, EF; Haig, AE; Frewer, PI H; Parkin, JM; Gleich, GJ; Grp, MH E S S. Treatment of patients with the hypereosinophilic syndrome with mepolizumab. The New England Journal of Medicine. 2008; 358:1215-1228.

Oliva, S; Aceves, SS; Zevit, N; Rothenberg, ME; Furuta, GT; Dellon, ES. Crafting a Therapeutic Pyramid for Eosinophilic Esophagitis in the Age of Biologics. Clinical Gastroenterology and Hepatology. 2024.

Sato, H; Dellon, ES; Aceves, SS; Arva, NC; Chehade, M; Collins, MH; Davis, CM; Falk, GW; Furuta, GT; Gonsalves, NP; Wechsler, JB; Yang, GY; Rothenberg, ME; Shoda, T. Clinical and molecular correlates of the Index of Severity for Eosinophilic Esophagitis. Journal of Allergy and Clinical Immunology. 2024; 154:375-386.e4.

Sun, KY; Bai, X; Chen, S; Bao, S; Zhang, C; Kapoor, M; Backman, J; Joseph, T; Maxwell, E; Mitra, G; Marchini, J; Reid, JG; Salerno, W; Balasubramanian, S. A deep catalogue of protein-coding variation in 983,578 individuals. Nature. 2024; 631:583-592.

Sato, H; Taylor, RJ; Sakai, N; Osonoi, K; Rothenberg, ME; Shoda, T. Eosinophil Involvement Outside the Esophagus in Eosinophilic Esophagitis. Clinical Gastroenterology and Hepatology. 2024; 22:1531-1534.e2.

Chehade, M; Dellon, ES; Spergel, JM; Collins, MH; Rothenberg, ME; Pesek, RD; Hirano, I; Liu, R; Laws, E; Mortensen, E; Patel, N; Yancopoulos, GD; Glotfelty, L; Maloney, J. Dupilumab for Eosinophilic Esophagitis in Patients 1 to 11 Years of Age. The New England Journal of Medicine. 2024; 390:2239-2251.

Rothenberg, ME; Dellon, ES; Collins, MH; Bredenoord, AJ; Hirano, I; Peterson, KA; Brooks, L; Caldwell, JM; Fjällbrant, H; Grindebacke, H; McCrae, C; Sinibaldi, D; White, WI; Datto, CJ. Eosinophil Depletion with Benralizumab for Eosinophilic Esophagitis. The New England Journal of Medicine. 2024; 390:2252-2263.

Furuta, GT; Dellon, ES; Straumann, A; Gonsalves, N; Rothenberg, ME; Hirano, I. Building and implementing a research infrastructure for eosinophilic gastrointestinal diseases. Journal of Allergy and Clinical Immunology. 2024; 153:1536-1539.

Shoda, T; Taylor, RJ; Sakai, N; Rothenberg, ME. Common and disparate clinical presentations and mechanisms in different eosinophilic gastrointestinal diseases. Journal of Allergy and Clinical Immunology. 2024; 153:1472-1484.

Lopez-Nunez, O; Bernieh, A; Kliewer, KL; Kemtur, P; Bolton, SM; Mukkada, VA; Schablein, R; Woods, C; Rothenberg, ME; Collins, MH. Transnasal Endoscopy Acquires Esophageal Biopsies Adequate for Comprehensive Pathology Evaluation in Patients With Eosinophilic Esophagitis. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 2024; 27:327-334.

Zhang, S; Caldwell, JM; Rochman, M; Collins, MH; Rothenberg, ME. Machine learning-based identification and characterization of mast cells in eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2024; 153:1381-1391.e6.

Skevaki, C; Nadeau, KC; Rothenberg, ME; Alahmad, B; Mmbaga, BT; Masenga, GG; Sampath, V; Christiani, DC; Haahtela, T; Renz, H. Impact of climate change on immune responses and barrier defense. Journal of Allergy and Clinical Immunology. 2024; 153:1194-1205.

Ruffner, MA; Shoda, T; Lal, M; Mrozek, Z; Muir, AB; Spergel, JM; Dellon, ES; Rothenberg, ME. Persistent esophageal changes after histologic remission in eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2024; 153:1063-1072.

Kim, B; Rothenberg, ME; Sun, X; Bachert, C; Artis, D; Zaheer, R; Deniz, Y; Rowe, P; Cyr, S. Neuroimmune interplay during type 2 inflammation: Symptoms, mechanisms, and therapeutic targets in atopic diseases. Journal of Allergy and Clinical Immunology. 2024; 153:879-893.

Macaluso, M; Rothenberg, ME; Ferkol, T; Kuhnell, P; Kaminski, HJ; Kimberlin, DW; Benatar, M; Chehade, M. Impact of the COVID-19 Pandemic on People Living With Rare Diseases and Their Families: Results of a National Survey. JMIR Public Health and Surveillance. 2024; 10:e48430.

Shook, MS; Lu, X; Chen, X; Parameswaran, S; Edsall, L; Trimarchi, MP; Ernst, K; Granitto, M; Forney, C; Donmez, OA; Diouf, AA; VonHandorf, A; Rothenberg, ME; Weirauch, MT; Kottyan, LC. Systematic identification of genotype-dependent enhancer variants in eosinophilic esophagitis. The American Journal of Human Genetics. 2024; 111:280-294.

Zhang, S; Caldwell, J; Rochman, M; Collins, M; Rothenberg, M. Machine Learning-Based Characterization of Esophageal Mast Cells in Eosinophilic Esophagitis Reveals Mast Cell Degranulation. Journal of Allergy and Clinical Immunology. 2024; 153:ab222.

Proper, SP; Dwyer, AT; Appiagyei, A; Felton, JM; Ben-Baruch Morgenstern, N; Marlman, JM; Kotliar, M; Barski, A; Troutman, TD; Rothenberg, ME; Mersha, TB; Azouz, NP. Aryl hydrocarbon receptor and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitis. Frontiers in Allergy. 2024; 5:1323405.

Papadopoulou, A; Amil-Dias, J; Auth, MK-H; Chehade, M; Collins, MH; Gupta, SK; Gutiérrez-Junquera, C; Orel, R; Vieira, MC; Zevit, N; Strauman, A; Thapar, N; Yang, G; Furuta, GT. Joint ESPGHAN/NASPGHAN Guidelines on Childhood Eosinophilic Gastrointestinal Disorders Beyond Eosinophilic Esophagitis. Journal of Pediatric Gastroenterology and Nutrition. 2024; 78:122-152.

Hirano, I; Dellon, ES; Falk, GW; Gonsalves, NP; Furuta, GT; Bredenoord, AJ; Straumann, A; Schoepfer, A; Chang, JW; Peterson, K; Vanuytsel, T; Woodland, P; Greuter, T; Kuang, FL. Ascending to New Heights for Novel Therapeutics for Eosinophilic Esophagitis. Gastroenterology. 2024; 166:1-10.

Xu, J; Cai, H; Wu, Z; Li, X; Tian, C; Ao, Z; Niu, VC; Xiao, X; Jiang, L; Khodoun, M; Rothenberg, M; Mackie, K; Chen, J; Lee, LP; Guo, F. Acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand management of acute disease. Nature Communications. 2023; 14:869.

Chehade, M; Wright, BL; Atkins, D; Aceves, SS; Ackerman, SJ; Assa'ad, AH; Bauer, M; Collins, MH; Commins, SP; Davis, CM; Wechsler, J; Zimmermann, N; Furuta, GT; Rothenberg, ME. Breakthroughs in understanding and treating eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERs Symposium at the 2022 American Academy of Allergy, Asthma & Immunology Meeting. Journal of Allergy and Clinical Immunology. 2023; 152:1382-1393.

Bedard, MC; Chihanga, T; Carlile, A; Jackson, R; Brusadelli, MG; Lee, D; VonHandorf, A; Rochman, M; Dexheimer, PJ; Chalmers, J; Lambert, PF; Adam, M; Steven Potter, S; Wells, SI. Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer. Nature Communications. 2023; 14:1975.

Melén, E; Lambrecht, BN; Lloyd, CM; Rothenberg, ME; Kabashima, K; Luciani, F; Coquet, JM; Ober, C; Nawijn, MC; Platts-Mills, T; von Mutius, E. A conversation on allergy: recognizing the past and looking to the future. Immunology and Cell Biology. 2023; 101:936-946.

Rothenberg, ME; Dellon, ES; Collins, MH; Hirano, I; Chehade, M; Bredenoord, AJ; Lucendo, AJ; Spergel, JM; Sun, X; Hamilton, JD; McCann, E; Liu, X; Glotfelty, L; Shabbir, A. Efficacy and safety of dupilumab up to 52 weeks in adults and adolescents with eosinophilic oesophagitis (LIBERTY EoE TREET study): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial. The Lancet Gastroenterology and Hepatology. 2023; 8:990-1004.

Hiremath, G; Sun, L; Collins, MH; Bonis, PA; Arva, NC; Capocelli, KE; Chehade, M; Davis, CM; Falk, GW; Gonsalves, N; Furuta, GT; Rothenberg, ME; Koyama, T; Dellon, ES. Esophageal Epithelium and Lamina Propria Are Unevenly Involved in Eosinophilic Esophagitis. Clinical Gastroenterology and Hepatology. 2023; 21:2807-2816.e3.

Rochman, Y; Kotliar, M; Morgenstern, NB B; Barski, A; Wen, T; Rothenberg, ME. TSLP shapes the pathogenic responses of memory CD4+ T cells in eosinophilic esophagitis. Science Signaling. 2023; 16:eadg6360.

Rochman, M; Rochman, Y; Caldwell, JM; Mack, LE; Besse, JA; Manes, NP; Yoon, SH; Shoda, T; Nita-Lazar, A; Rothenberg, ME. The minichromosome maintenance complex drives esophageal basal zone hyperplasia. JCI insight. 2023; 8.

Kliewer, KL; Murray-Petzold, C; Collins, MH; Abonia, JP; Bolton, SM; DiTommaso, LA; Martin, LJ; Zhang, X; Mukkada, VA; Putnam, PE; Lyles, JL; Shoda, T; Klion, AD; Rothenberg, ME. Benralizumab for eosinophilic gastritis: a single-site, randomised, double-blind, placebo-controlled, phase 2 trial. The Lancet Gastroenterology and Hepatology. 2023; 8:803-815.

Uchida, AM; Burk, CM; Rothenberg, ME; Furuta, GT; Spergel, JM. Recent Advances in the Treatment of Eosinophilic Esophagitis. The Journal of Allergy and Clinical Immunology: in Practice. 2023; 11:2654-2663.

Gonsalves, N; Doerfler, B; Zalewski, A; Yang, GY; Martin, LJ; Zhang, X; Shoda, T; Brusilovsky, M; Aceves, S; Thompson, K; Rudman Spergel, AK; Furuta, G; Rothenberg, ME; Hirano, I. Prospective study of an amino acid-based elemental diet in an eosinophilic gastritis and gastroenteritis nutrition trial. Journal of Allergy and Clinical Immunology. 2023; 152:676-688.

Aknin, E; Larey, A; Caldwell, JM; Collins, MH; Rothenberg, ME; Savir, Y. (2023) Harnessing Digital Pathology And Causal Learning To Improve Eosinophilic Esophagitis Dietary Treatment Assignment. Institute of Electrical and Electronics Engineers (IEEE). 00:1-8.

Rothenberg, ME. The immunology that underlies picky eating. Nature. 2023; 620:497-499.

Ben-Baruch Morgenstern, N; Shoda, T; Rochman, Y; Caldwell, JM; Collins, MH; Mukkada, V; Putnam, PE; Bolton, SM; Felton, JM; Rochman, M; Murray-Petzold, C; Kliewer, KL; Rothenberg, ME. Local type 2 immunity in eosinophilic gastritis. Journal of Allergy and Clinical Immunology. 2023; 152:136-144.

Chang, JW; Kliewer, K; Haller, E; Lynett, A; Doerfler, B; Katzka, DA; Peterson, KA; Dellon, ES; Gonsalves, N; Aceves, SS; Rothenberg, ME; Spergel, JM; Strobel, MJ; Wechsler, JB. Development of a Practical Guide to Implement and Monitor Diet Therapy for Eosinophilic Esophagitis. Clinical Gastroenterology and Hepatology. 2023; 21:1690-1698.

Parsons, ES; Liu, F; Kaushik, A; Lee, A; Schuetz, J; Dunham, D; Seastedt, H; Ogulur, I; Heider, A; Tan, G; Leib, R; Akdis, CA; Nadeau, K; Lejeune, S. Detection of gut and mucosal peptides through TOMAHAQ in healthy individuals. Allergy: European Journal of Allergy and Clinical Immunology. 2023; 78:2052-2055.

Hwee, J; Huynh, L; Du, S; Kwon, N; Jakes, RW; Alfonso-Cristancho, R; Baylis, L; Requena, G; Khanal, A; Rothenberg, ME; Sheng Duh, M. Hypereosinophilic syndrome in Europe: Retrospective study of treatment patterns, clinical manifestations, and healthcare resource utilization. Annals of Allergy, Asthma, and Immunology. 2023; 130:768-775.

Kliewer, KL; Gonsalves, N; Dellon, ES; Katzka, DA; Abonia, JP; Aceves, SS; Arva, NC; Besse, JA; Bonis, PA; Caldwell, JM; Yang, GY; Zhang, X; Furuta, GT; Rothenberg, ME. One-food versus six-food elimination diet therapy for the treatment of eosinophilic oesophagitis: a multicentre, randomised, open-label trial. The Lancet Gastroenterology and Hepatology. 2023; 8:408-421.

Soh, WT; Zhang, J; Hollenberg, MD; Vliagoftis, H; Rothenberg, ME; Sokol, CL; Robinson, C; Jacquet, A. Protease allergens as initiators-regulators of allergic inflammation. Allergy: European Journal of Allergy and Clinical Immunology. 2023; 78:1148-1168.

Brusilovsky, M; Rochman, M; Shoda, T; Kotliar, M; Caldwell, JM; Mack, LE; Besse, JA; Chen, X; Weirauch, MT; Barski, A; Rothenberg, ME. Vitamin D receptor and STAT6 interactome governs oesophageal epithelial barrier responses to IL-13 signalling. Gut. 2023; 72:834-845.

Guarnieri, KM; Saba, NK; Schwartz, JT; Devonshire, AL; Bufford, J; Casale, TB; Rothenberg, ME; Andorf, S. Food Allergy Characteristics Associated With Coexisting Eosinophilic Esophagitis in FARE Registry Participants. The Journal of Allergy and Clinical Immunology: in Practice. 2023; 11:1509-1521.e6.

Bousquet, J; Melén, E; Haahtela, T; Koppelman, GH; Togias, A; Valenta, R; Akdis, CA; Czarlewski, W; Rothenberg, M; Valiulis, A; Berghea, EC; Bergmann, KC; Bernstein, D; Bewick, M. Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis. Allergy: European Journal of Allergy and Clinical Immunology. 2023; 78:1169-1203.

Gautam, Y; Caldwell, J; Kottyan, L; Chehade, M; Dellon, ES; Rothenberg, ME; Mersha, TB; Wechsler, J; Davis, C; Furuta, G; Falk, G; Hirano, I; Gonsalves, NP; Peterson, K. Genome-wide admixture and association analysis identifies African ancestry-specific risk loci of eosinophilic esophagitis in African Americans. Journal of Allergy and Clinical Immunology. 2023; 151:1337-1350.

Dellon, ES; Rothenberg, ME; Collins, MH; Hirano, I; Chehade, M; Bredenoord, AJ; Lucendo, AJ; Spergel, JM; Sun, X; Hamilton, JD; Mannent, LP; Maroni, J; Patel, K; Shabbir, A. Dupilumab efficacy and safety up to 52weeks in adult and adolescent patients with eosinophilic esophagitis: Results from parts B and C of the randomized, placebo-controlled, three-part, phase 3 LIBERTY EoE TREET Study. Revue Française d'Allergologie et d'Immunologie Clinique. 2023; 63:103594.

Hirano, I; Rothenberg, ME; Zhang, S; De Oliveira, C; Charriez, CM; Coyne, KS; Bacci, ED; Dellon, ES. Dysphagia Days as an Assessment of Clinical Treatment Outcome in Eosinophilic Esophagitis. The American Journal of Gastroenterology (Elsevier). 2023; 118:744-747.

Talley, NJ; Peterson, KA; Genta, RM; Chang, AT; Dellon, ES; Sandborn, WJ; Lacy, BE; Chehade, M; Hirano, I; Gonsalves, N; Jain, N; Pletneva, MA; Turner, KO; Youngblood, BA. High Discovery Rate of Duodenal and Gastric Eosinophilia in Patients With Unexplained Moderate-Severe Abdominal Symptoms: A Prospective US Multisite Study. Gastroenterology. 2023; 164:680-683.e2.

Shoda, T; Rochman, M; Collins, MH; Caldwell, JM; Mack, LE; Osswald, GA; Mukkada, VA; Putnam, PE; Rothenberg, ME. Molecular analysis of duodenal eosinophilia. Journal of Allergy and Clinical Immunology. 2023; 151:1027-1039.

Applequist, J; Burroughs, C; Merkel, PA; Rothenberg, M; Trapnell, B; Desnick, R; Sahin, M; Krischer, J. Direct-to-Consumer Recruitment Methods via Traditional and Social Media to Aid in Research Accrual for Clinical Trials for Rare Diseases: Comparative Analysis Study. Journal of Medical Internet Research. 2023; 25:e39262.

Dellon, ES; Rothenberg, ME; Bredenoord, AJ. Dupilumab in Patients with Eosinophilic Esophagitis. Reply. The New England Journal of Medicine. 2023; 388:956-957.

Rothenberg, ME; Bousquet, J. News beyond our pages. Journal of Allergy and Clinical Immunology. 2023; 151:679-680.

Furuta, GT; Fillon, SA; Williamson, KM; Robertson, CE; Stevens, MJ; Aceves, SS; Arva, NC; Chehade, M; Collins, MH; Davis, CM; Wechsler, JB; Yang, GY; Rothenberg, ME; Harris, JK. Mucosal Microbiota Associated With Eosinophilic Esophagitis and Eosinophilic Gastritis. Journal of Pediatric Gastroenterology and Nutrition. 2023; 76:347-354.

Sindher, SB; Barshow, S; Tirumalasetty, J; Arasi, S; Atkins, D; Bauer, M; Bégin, P; Collins, MH; Deschildre, A; Doyle, AD; Chin, AR; Long, A; Nadeau, KC; Chinthrajah, RS. The role of biologics in pediatric food allergy and eosinophilic gastrointestinal disorders. Journal of Allergy and Clinical Immunology. 2023; 151:595-606.

Caldwell, J; Ballaban, A; Li, J; Maddux, R; Harris, S; Rothenberg, M. Anti–IL-13 (cendakimab) administration improves esophageal gene expression in eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2023; 151:ab215.

Alvarado, D; Lu, Y; Shoda, T; Caldwell, JM; Keler, T; Rothenberg, ME. Strong association of mast cells with eosinophilic esophagitis-specific signatures. Allergy: European Journal of Allergy and Clinical Immunology. 2023; 78:583-586.

Rothenberg, ME; Bousquet, J. News beyond our pages. Journal of Allergy and Clinical Immunology. 2023; 151:405-406.

Avlas, S; Shani, G; Rhone, N; Itan, M; Dolitzky, A; Hazut, I; Grisaru-Tal, S; Gordon, Y; Shoda, T; Ballaban, A; Benhar, I; Varol, C; Rothenberg, ME; Munitz, A. Epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis. Allergy: European Journal of Allergy and Clinical Immunology. 2023; 78:464-476.

Chehade, M; Furuta, G; Klion, A; Abonia, JP; Aceves, S; Bose, P; Collins, MH; Davis, C; Dellon, ES; Eickel, G; Zicarelli, A; Muir, AB; Wright, BL; Bailey, DD. Enhancing diversity, equity, inclusion, and accessibility in eosinophilic gastrointestinal disease research: the consortium for eosinophilic gastrointestinal disease researchers' journey. Therapeutic Advances in Rare Disease. 2023; 4:26330040231180895.

Rothenberg, ME; Bousquet, J. News beyond our pages. Journal of Allergy and Clinical Immunology. 2023; 151:104-105.

Dellon, ES; Rothenberg, ME; Collins, MH; Hirano, I; Chehade, M; Bredenoord, AJ; Lucendo, AJ; Spergel, JM; Aceves, S; Sun, X; Shumel, B; Maloney, J; Giannelou, A; Shabbir, A. Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis. The New England Journal of Medicine. 2022; 387:2317-2330.

Rothenberg, ME. Scientific journey to the first FDA-approved drug for eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2022; 150:1325-1332.

Rothenberg, ME; Bousquet, J. News beyond our pages. Journal of Allergy and Clinical Immunology. 2022; 150:1401-1402.

Dellon, ES; Gonsalves, N; Abonia, JP; Alexander, JA; Arva, NC; Atkins, D; Attwood, SE; Auth, MK H; Bailey, DD; Biederman, L; Zevit, N; Rothenberg, ME; Furuta, GT; Aceves, SS. International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature. Clinical Gastroenterology and Hepatology. 2022; 20:2474-2484.e3.

Rothenberg, ME; Bousquet, J. News beyond our pages. Journal of Allergy and Clinical Immunology. 2022; 150:1040-1041.

Larey, A; Aknin, E; Daniel, N; Osswald, GA; Caldwell, JM; Rochman, M; Wasserman, T; Collins, MH; Arva, NC; Yang, GY; Rothenberg, ME; Savir, Y. Harnessing artificial intelligence to infer novel spatial biomarkers for the diagnosis of eosinophilic esophagitis. Frontiers in Medicine. 2022; 9:950728.

Schreiner, P; Safroneeva, E; Schoepfer, A; Greuter, T; Biedermann, L; Schlag, C; Labenz, J; Auth, MK H; Bredenoord, AJ; Chang, JW; Dellon, ES; Straumann, A; Furuta, GT; Gonsalves, N. Management of eosinophilic esophagitis associated food impaction in Europe and the United States. Diseases of the Esophagus. 2022; 35.

Grisaru-Tal, S; Rothenberg, ME; Munitz, A. Eosinophil-lymphocyte interactions in the tumor microenvironment and cancer immunotherapy. Nature Immunology. 2022; 23:1309-1316.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2022; 150:575-576.

Rothenberg, ME; Roufosse, F; Faguer, S; Gleich, GJ; Steinfeld, J; Yancey, SW; Mavropoulou, E; Kwon, N; García, GR; Sosso, A; Butterfield, JH; Chupp, GL; Cox, JB; Jhaveri, D. Mepolizumab Reduces Hypereosinophilic Syndrome Flares Irrespective of Blood Eosinophil Count and Interleukin-5. The Journal of Allergy and Clinical Immunology: in Practice. 2022; 10:2367-2374.e3.

Seibold, MA; Moore, CM; Everman, JL; Williams, BJ M; Nolin, JD; Fairbanks-Mahnke, A; Plender, EG; Patel, BB; Arbes, SJ; Bacharier, LB; Zoratti, EM; Togias, A; Fulkerson, PC; Hartert, TV. Risk factors for SARS-CoV-2 infection and transmission in households with children with asthma and allergy: A prospective surveillance study. Journal of Allergy and Clinical Immunology. 2022; 150:302-311.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2022; 150:282-283.

McNaught, E; Treasure, J; Pollard, N. Overview. Eating Disorders. : Oxford University Press (OUP); Oxford University Press (OUP); 2022.

Daniel, N; Larey, A; Aknin, E; Osswald, G; Caldwell, J; Rochman, M; Collins, M; Yang, GY; Arva, N; Capocelli, K; Rothenberg, M; Savir, Y. A Deep Multi-Label Segmentation Network For Eosinophilic Esophagitis Whole Slide Biopsy Diagnostics. 2022; 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022:3211-3217.

Daniel, N; Larey, A; Aknin, E; Osswald, GA; Caldwell, JM; Rochman, M; Collins, MH; Yang, GY; Arva, NC; Capocelli, KE; Rothenberg, ME; Savir, Y. (2022) A Deep Multi-Label Segmentation Network For Eosinophilic Esophagitis Whole Slide Biopsy Diagnostics. 2022:3211-3217.

Fulkerson, PC; Lussier, SJ; Bendixsen, CG; Castina, SM; Gebretsadik, T; Marlin, JS; Russell, PB; Seibold, MA; Everman, JL; Moore, CM; Teach, SJ; Zoratti, EM; Togias, A; Hartert, TV. Human Epidemiology and RespOnse to SARS-CoV-2 (HEROS): Objectives, Design and Enrollment Results of a 12-City Remote Observational Surveillance Study of Households with Children using Direct-to-Participant Methods. 2022.

Dellon, ES; Khoury, P; Muir, AB; Liacouras, CA; Safroneeva, E; Atkins, D; Collins, MH; Gonsalves, N; Falk, GW; Spergel, JM; Rothenberg, ME; Straumann, A; Furuta, GT; Aceves, SS. A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions. Journal of Allergy and Clinical Immunology. 2022; 150:33-47.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2022; 150:54-55.

Droghini, HR; Abonia, JP; Collins, MH; Milner, JD; Lyons, JJ; Freeman, AF; Mukkada, VA; Risma, KA; Rothenberg, ME; Schwartz, JT. Targeted IL-4Rα blockade ameliorates refractory allergic eosinophilic inflammation in a patient with dysregulated TGF-β signaling due to ERBIN deficiency. The Journal of Allergy and Clinical Immunology: in Practice. 2022; 10:1903-1906.

Dellon, ES; Khoury, P; Muir, AB; Liacouras, CA; Safroneeva, E; Atkins, D; Collins, MH; Gonsalves, N; Falk, GW; Spergel, JM; Rothenberg, ME; Straumann, A; Furuta, GT; Aceves, SS. A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions. Gastroenterology. 2022; 163:59-76.

Tanzer, J; Meng, D; Ohsaki, A; Caldwell, JM; Mingler, MK; Rothenberg, ME; Oyoshi, MK. Laundry detergent promotes allergic skin inflammation and esophageal eosinophilia in mice. PloS one. 2022; 17:e0268651.

Rochman, M; Wen, T; Kotliar, M; Dexheimer, PJ; Morgenstern, NB B; Caldwell, JM; Lim, HW; Rothenberg, ME. Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation. JCI insight. 2022; 7.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2022; 149:1934-1935.

Ben-Baruch Morgenstern, N; Ballaban, AY; Wen, T; Shoda, T; Caldwell, JM; Kliewer, K; Felton, JM; Abonia, JP; Mukkada, VA; Putnam, PE; Bolton, SM; Dwyer, DF; Barrett, NA; Rothenberg, ME. Single-cell RNA sequencing of mast cells in eosinophilic esophagitis reveals heterogeneity, local proliferation, and activation that persists in remission. Journal of Allergy and Clinical Immunology. 2022; 149:2062-2077.

Zhang, S; Shoda, T; Aceves, SS; Arva, NC; Chehade, M; Collins, MH; Dellon, ES; Falk, GW; Gonsalves, N; Gupta, SK; Wechsler, JB; Yang, GY; Furuta, GT; Rothenberg, ME. Mast cell-pain connection in eosinophilic esophagitis. Allergy: European Journal of Allergy and Clinical Immunology. 2022; 77:1895-1899.

Eapen, AA; Parameswaran, S; Forney, C; Edsall, LE; Miller, D; Donmez, O; Dunn, K; Lu, X; Granitto, M; Rowden, H; Devonshire, AL; Rothenberg, ME; Weirauch, MT; Kottyan, LC. Epigenetic and transcriptional dysregulation in CD4+ T cells in patients with atopic dermatitis. PLoS Genetics. 2022; 18:e1009973.

Chen, MM; Roufosse, F; Wang, SA; Verstovsek, S; Durrani, SR; Rothenberg, ME; Pongdee, T; Butterfield, J; Lax, T; Wechsler, ME; Fay, MP; Khoury, P; Klion, AD; Bochner, BS. An International, Retrospective Study of Off-Label Biologic Use in the Treatment of Hypereosinophilic Syndromes. The Journal of Allergy and Clinical Immunology: in Practice. 2022; 10:1217-1228.e3.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2022; 149:1572-1573.

Rothenberg, ME. The climate change hypothesis for the allergy epidemic. Journal of Allergy and Clinical Immunology. 2022; 149:1522-1524.

Shoda, T; Collins, MH; Rochman, M; Wen, T; Caldwell, JM; Mack, LE; Osswald, GA; Besse, JA; Haberman, Y; Aceves, SS; Mingler, M; Minnicozzi, M; Muir, A; Murray-Petzold, C. Evaluating Eosinophilic Colitis as a Unique Disease Using Colonic Molecular Profiles: A Multi-Site Study. Gastroenterology. 2022; 162:1635-1649.

Haberman Ziv, Y; Collins, MH; Gonsalves, N; Katzka, DA; Rothenberg, ME. Eosinophilic esophagitis. Yamada's Atlas of Gastroenterology. : Wiley; Wiley; 2022.

Safroneeva, E; Pan, Z; King, E; Martin, LJ; Collins, MH; Yang, GY; Capocelli, KE; Arva, NC; Abonia, JP; Atkins, D; Wershil, BK; Rothenberg, ME; Aceves, SS; Furuta, GT. Long-Lasting Dissociation of Esophageal Eosinophilia and Symptoms After Dilation in Adults With Eosinophilic Esophagitis. Clinical Gastroenterology and Hepatology. 2022; 20:766-775.e4.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2022; 149:1201-1202.

Robida, PA; Rische, CH; Morgenstern, NB B; Janarthanam, R; Cao, Y; Krier-Burris, RA; Korver, W; Xu, A; Luu, T; Schanin, J; Wechsler, JB; Youngblood, BA; Bochner, BS; O’Sullivan, JA. Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells. Cells. 2022; 11.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2022; 149:879-880.

Hirano, I; Collins, MH; King, E; Sun, Q; Chehade, M; Abonia, JP; Bonis, PA; Capocelli, KE; Dellon, ES; Falk, GW; Yang, GY; Rothenberg, ME; Aceves, SS; Furuta, GT. Prospective Endoscopic Activity Assessment for Eosinophilic Gastritis in a Multisite Cohort. The American Journal of Gastroenterology (Elsevier). 2022; 117:413-423.

Dellon, ES; Gonsalves, N; Rothenberg, ME; Hirano, I; Chehade, M; Peterson, KA; Falk, GW; Murray, JA; Gehman, LT; Chang, AT; Singh, B; Rasmussen, HS; Genta, RM. Determination of Biopsy Yield That Optimally Detects Eosinophilic Gastritis and/or Duodenitis in a Randomized Trial of Lirentelimab. Clinical Gastroenterology and Hepatology. 2022; 20:535-545.e15.

Collins, MH; Alexander, ES; Martin, LJ; Grotjan, TM; Mukkada, VA; Sheil, A; Abonia, JP; Putnam, PE; Rothenberg, ME. Acquired Esophageal Strictures in Children: Morphometric and Immunohistochemical Analyses. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 2022; 25:124-133.

Rothenberg, ME; Hottinger, SK B; Gonsalves, N; Furuta, GT; Collins, MH; Talley, NJ; Peterson, K; Menard-Katcher, C; Smith, M; Hirano, I; Gupta, SK; Spergel, JM; Aceves, SS; Dellon, ES. Impressions and aspirations from the FDA GREAT VI Workshop on Eosinophilic Gastrointestinal Disorders Beyond Eosinophilic Esophagitis and Perspectives for Progress in the Field. Journal of Allergy and Clinical Immunology. 2022; 149:844-853.

Dunn, JL M; Rothenberg, ME. 2021 year in review: Spotlight on eosinophils. Journal of Allergy and Clinical Immunology. 2022; 149:517-524.

Rothenberg, ME. Linking the allergy epidemic to climate change. Nature Immunology. 2022; 23:149.

Brusilovsky, M; Bao, R; Rochman, M; Kemter, AM; Nagler, CR; Rothenberg, ME. Host-Microbiota Interactions in the Esophagus During Homeostasis and Allergic Inflammation. Gastroenterology. 2022; 162:521-534.e8.

Min, S; Shoda, T; Wen, T; Rothenberg, ME. Diagnostic merits of the Eosinophilic Esophagitis Diagnostic Panel from a single esophageal biopsy. Journal of Allergy and Clinical Immunology. 2022; 149:782-787.e1.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2022; 149:531-532.

Ma, C; Schoepfer, AM; Dellon, ES; Bredenoord, AJ; Chehade, M; Collins, MH; Feagan, BG; Furuta, GT; Gupta, SK; Hirano, I; Woosley, JT; Yang, GY; Zevit, N; Safroneeva, E. Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS). Journal of Allergy and Clinical Immunology. 2022; 149:659-670.

Shoda, T; Wen, T; Caldwell, JM; Ben-Baruch Morgenstern, N; Osswald, GA; Rochman, M; Mack, LE; Felton, JM; Abonia, JP; Arva, NC; Mingler, M; Minnicozzi, M; Muir, A; MurrayPetzold, C. Loss of Endothelial TSPAN12 Promotes Fibrostenotic Eosinophilic Esophagitis via Endothelial Cell-Fibroblast Crosstalk. Gastroenterology. 2022; 162:439-453.

Hiremath, G; Sun, L; Correa, H; Acra, S; Collins, MH; Bonis, P; Arva, NC; Capocelli, KE; Falk, GW; King, E; Furuta, GT; Rothenberg, ME; Koyama, T; Dellon, ES. Development and Validation of Web-Based Tool to Predict Lamina Propria Fibrosis in Eosinophilic Esophagitis. The American Journal of Gastroenterology (Elsevier). 2022; 117:272-279.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2022; 149:35-36.

Gleich, GJ; Roufosse, F; Chupp, G; Faguer, S; Walz, B; Reiter, A; Yancey, SW; Bentley, JH; Steinfeld, J; García, GR; Akuthota, P; Butterfield, JH; Jhaveri, D; Rothenberg, ME. Safety and Efficacy of Mepolizumab in Hypereosinophilic Syndrome: An Open-Label Extension Study. The Journal of Allergy and Clinical Immunology: in Practice. 2021; 9:4431-4440.e1.

Shoda, T; Kaufman, KM; Wen, T; Caldwell, JM; Osswald, GA; Purnima, P; Zimmermann, N; Collins, MH; Rehn, K; Foote, H; Mukkada, VA; Putnam, PE; Martin, LJ; Rothenberg, ME. Desmoplakin and periplakin genetically and functionally contribute to eosinophilic esophagitis. Nature Communications. 2021; 12:6795.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2021; 148:1468-1469.

Fox-Fisher, I; Piyanzin, S; Ochana, BL; Klochendler, A; Magenheim, J; Peretz, A; Loyfer, N; Moss, J; Cohen, D; Drori, Y; Kaplan, T; Glaser, B; Shemer, R; Dor, Y. Remote immune processes revealed by immune-derived circulating cell-free DNA. eLife. 2021; 10.

Grisaru-Tal, S; Dulberg, S; Beck, L; Zhang, C; Itan, M; Hediyeh-Zadeh, S; Caldwell, J; Rozenberg, P; Dolitzky, A; Avlas, S; Yu, H; Geiger, T; Madi, A; Munitz, A. Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity. Cancer Research. 2021; 81:5555-5571.

Felton, JM; Bouffi, C; Schwartz, JT; Schollaert, KL; Malik, A; Vallabh, S; Wronowski, B; Magier, AZ; Merlin, L; Barski, A; Weirauch, MT; Fulkerson, PC; Rothenberg, ME. Aiolos regulates eosinophil migration into tissues. Mucosal Immunology. 2021; 14:1271-1281.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2021; 148:1146-1147.

Mahoney, M; Damalanka, VC; Tartell, MA; Chung, DH; Lourenço, AL; Pwee, D; Mayer Bridwell, AE; Hoffmann, M; Voss, J; Karmakar, P; Whelan, SP J; O’Donoghue, AJ; Craik, CS; Janetka, JW. A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells. Proceedings of the National Academy of Sciences of USA. 2021; 118.

Jin, K; Bardes, EE; Mitelpunkt, A; Wang, JY; Bhatnagar, S; Sengupta, S; Krummel, DP; Rothenberg, ME; Aronow, BJ. An interactive single cell web portal identifies gene and cell networks in COVID-19 host responses. iScience. 2021; 24:103115.

Brusilovsky, M; Rochman, M; Rochman, Y; Caldwell, JM; Mack, LE; Felton, JM; Habel, JE; Porollo, A; Pasare, C; Rothenberg, ME. Environmental allergens trigger type 2 inflammation through ripoptosome activation. Nature Immunology. 2021; 22:1316-1326.

Ma, C; Schoepfer, AM; Safroneeva, E; Dellon, ES; Bredenoord, AJ; Chehade, M; Collins, MH; Feagan, BG; Furuta, GT; Gupta, SK; Woodland, P; Woosley, JT; Yang, GY; Zevit, N. (2021) A Summary of the Meetings of the Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS) International Multidisciplinary Consensus. 161:778-784.

Hiremath, G; Krischer, JP; Rothenberg, ME; Dellon, ES. Validation of self-reported diagnosis of eosinophilic gastrointestinal disorders patients enrolled in the CEGIR contact registry. Clinics and Research in Hepatology and Gastroenterology. 2021; 45:101555.

Friedlander, JA; Fleischer, DM; Black, JO; Levy, M; Rothenberg, ME; Smith, C; Nguyen, N; Pan, Z; Furuta, GT. Unsedated transnasal esophagoscopy with virtual reality distraction enables earlier monitoring of dietary therapy in eosinophilic esophagitis. The Journal of Allergy and Clinical Immunology: in Practice. 2021; 9:3494-3496.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2021; 148:700-701.

Dunn, JL M; Caldwell, JM; Ballaban, A; Ben-Baruch Morgenstern, N; Rochman, M; Rothenberg, ME. Bidirectional crosstalk between eosinophils and esophageal epithelial cells regulates inflammatory and remodeling processes. Mucosal Immunology. 2021; 14:1133-1143.

Ma, C; Schoepfer, AM; Safroneeva, E; Dellon, ES; Bredenoord, AJ; Chehade, M; Collins, MH; Feagan, BG; Furuta, GT; Gupta, SK; Woodland, P; Woosley, JT; Yang, GY; Zevit, N. Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS): An International Multidisciplinary Consensus. Gastroenterology. 2021; 161:748-755.

Felton, JM; Vallabh, S; Parameswaran, S; Edsall, LE; Ernst, K; Wronowski, B; Malik, A; Kotliar, M; Weirauch, MT; Barski, A; Fulkerson, PC; Rothenberg, ME. Epigenetic Analysis of the Chromatin Landscape Identifies a Repertoire of Murine Eosinophil-Specific PU.1-Bound Enhancers. Journal of immunology (Baltimore, Md. : 1950). 2021; 207:1044-1054.

Morgenstern, NB B; Rochman, M; Rothenberg, ME. Zooming in on T cell clones: Are we heading to personalized treatment of allergy?. Science Immunology. 2021; 6.

Rothenberg, ME; Bousquet, J. News beyond our pages. Journal of Allergy and Clinical Immunology. 2021; 148:342-343.

Rothenberg, ME; Bousquet, J. News beyond our pages. Journal of Allergy and Clinical Immunology. 2021; 148:59-60.

Jin, K; Bardes, EE; Mitelpunkt, A; Wang, JY; Bhatnagar, S; Sengupta, S; Krummel, DP; Rothenberg, ME; Aronow, BJ. Implicating Gene and Cell Networks Responsible for Differential COVID-19 Host Responses via an Interactive Single Cell Web Portal. 2021.

Rothenberg, ME. An Allergic Basis for Abdominal Pain. The New England Journal of Medicine. 2021; 384:2156-2158.

Sabet, C; Klion, AD; Bailey, D; Jensen, E; Chehade, M; Abonia, JP; Rothenberg, ME; Furuta, GT; Muir, AB. Do rural health disparities affect prevalence data in pediatric eosinophilic esophagitis?. The Journal of Allergy and Clinical Immunology: in Practice. 2021; 9:2549-2551.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2021; 147:2058-2059.

Chiang, AW T; Duong, LD; Shoda, T; Nhu, QM; Ruffner, M; Hara, T; Aaron, B; Joplin, E; Manresa, MC; Abonia, JP; Rothenberg, ME; Lewis, NE; Muir, AB; Aceves, SS. Type 2 Immunity and Age Modify Gene Expression of Coronavirus-induced Disease 2019 Receptors in Eosinophilic Gastrointestinal Disorders. Journal of Pediatric Gastroenterology and Nutrition. 2021; 72:718-722.

Rochman, M; Xie, YM; Mack, L; Caldwell, JM; Klingler, AM; Osswald, GA; Azouz, NP; Rothenberg, ME. Broad transcriptional response of the human esophageal epithelium to proton pump inhibitors. Journal of Allergy and Clinical Immunology. 2021; 147:1924-1935.

Azouz, NP; Klingler, AM; Callahan, V; Akhrymuk, IV; Elez, K; Raich, L; Henry, BM; Benoit, JL; Benoit, SW; Noé, F; Kehn-Hall, K; Rothenberg, ME. Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2. Pathogens and Immunity. 2021; 6:55-74.

Jacobsen, EA; Jackson, DJ; Heffler, E; Mathur, SK; Bredenoord, AJ; Pavord, ID; Akuthota, P; Roufosse, F; Rothenberg, ME. Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies. Annual Review of Immunology. 2021; 39:719-757.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2021; 147:1202-1203.

Mersha, TB; Afanador, Y; Johansson, E; Proper, SP; Bernstein, JA; Rothenberg, ME; Hershey, GK K. Resolving Clinical Phenotypes into Endotypes in Allergy: Molecular and Omics Approaches. Clinical Reviews in Allergy and Immunology. 2021; 60:200-219.

Dellon, ES; Collins, MH; Rothenberg, ME; Assouline-Dayan, Y; Evans, L; Gupta, S; Schoepfer, A; Straumann, A; Safroneeva, E; Rodriguez, C; Minton, N; Hua, SY; Hirano, I. Long-term Efficacy and Tolerability of RPC4046 in an Open-Label Extension Trial of Patients With Eosinophilic Esophagitis. Clinical Gastroenterology and Hepatology. 2021; 19:473-483.e17.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2021; 147:851-852.

Dellon, ES; Shaheen, O; Koutlas, NT; Chang, AO; Martin, LJ; Rothenberg, ME; Jensen, ET. Early life factors are associated with risk for eosinophilic esophagitis diagnosed in adulthood. Diseases of the Esophagus. 2021; 34.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2021; 147:490-491.

Hempel, T; Raich, L; Olsson, S; Azouz, NP; Klingler, AM; Hoffmann, M; Pöhlmann, S; Rothenberg, ME; Noé, F. Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat. Chemical Science. 2021; 12:983-992.

Lyles, JL; Martin, LJ; Shoda, T; Collins, MH; Trimarchi, MP; He, H; Kottyan, LC; Mukkada, VA; Rothenberg, ME. Very early onset eosinophilic esophagitis is common, responds to standard therapy, and demonstrates enrichment for CAPN14 genetic variants. Journal of Allergy and Clinical Immunology. 2021; 147:244-254.e6.

Kottyan, LC; Trimarchi, MP; Lu, X; Caldwell, JM; Maddox, A; Parameswaran, S; Lape, M; D'Mello, RJ; Bonfield, M; Ballaban, A; Eapen, AA; Wen, T; Weirauch, MT; Rothenberg, ME. Replication and meta-analyses nominate numerous eosinophilic esophagitis risk genes. Journal of Allergy and Clinical Immunology. 2021; 147:255-266.

O'Shea, KM; Rochman, M; Shoda, T; Zimmermann, N; Caldwell, J; Rothenberg, ME. Eosinophilic esophagitis with extremely high esophageal eosinophil counts. Journal of Allergy and Clinical Immunology. 2021; 147:409-412.e5.

Czyzewski, T; Daniel, N; Rochman, M; Caldwell, J; Osswald, G; Collins, M; Rothenberg, M; Savir, Y. Machine Learning Approach for Biopsy-Based Identification of Eosinophilic Esophagitis Reveals Importance of Global features. IEEE Open Journal of Engineering in Medicine and Biology. 2021; 2:218-223.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 146:1341-1342.

Applequist, J; Burroughs, C; Jr, RA; Merkel, PA; Rothenberg, ME; Trapnell, B; Desnick, RJ; Sahin, M; Krischer, JP. A novel approach to conducting clinical trials in the community setting: utilizing patient-driven platforms and social media to drive web-based patient recruitment. BMC Medical Research Methodology. 2020; 20:58.

Roufosse, F; Kahn, JE; Rothenberg, ME; Wardlaw, AJ; Klion, AD; Kirby, SY; Gilson, MJ; Bentley, JH; Bradford, ES; Yancey, SW; Steinfeld, J; Gleich, GJ. Efficacy and safety of mepolizumab in hypereosinophilic syndrome: A phase III, randomized, placebo-controlled trial. Journal of Allergy and Clinical Immunology. 2020; 146:1397-1405.

Rothenberg, ME. Transferring allergies in the womb. Science. 2020; 370:907-908.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 146:993-994.

Dellon, ES; Peterson, KA; Murray, JA; Falk, GW; Gonsalves, N; Chehade, M; Genta, RM; Leung, J; Khoury, P; Klion, AD; Kamboj, AP; Rasmussen, HS; Rothenberg, ME; Hirano, I. Anti-Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis. The New England Journal of Medicine. 2020; 383:1624-1634.

Jensen, ET; Aceves, SS; Bonis, PA; Bray, K; Book, W; Chehade, M; Collins, MH; Dellon, ES; Falk, GW; Gonsalves, N; Strobel, MJ; Krischer, J; Rothenberg, ME; Abonia, P. High Patient Disease Burden in a Cross-sectional, Multicenter Contact Registry Study of Eosinophilic Gastrointestinal Diseases. Journal of Pediatric Gastroenterology and Nutrition. 2020; 71:524-529.

Ben Baruch-Morgenstern, N; Rochman, M; Rothenberg, ME. Pumping mast cells out of allergic inflammation-are proton pump inhibitors taking center stage?. Journal of Allergy and Clinical Immunology. 2020; 146:783-785.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 146:774-775.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 146:507-508.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 146:256-257.

Brusilovsky, M; Rochman, M; Azouz, NP; Mack, LE; Rothenberg, ME. Uncovering the secretes of allergic inflammation. The Journal of Clinical Investigation. 2020; 130:3419-3421.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 146:50-51.

Pesek, RD; Reed, CC; Collins, MH; Muir, AB; Fulkerson, PC; Menard-Katcher, C; Falk, GW; Kuhl, J; Magier, AZ; Ahmed, FN; Furuta, GT; Rothenberg, ME; Dellon, ES; Gastrointe, CE. Association Between Endoscopic and Histologic Findings in a Multicenter Retrospective Cohort of Patients with Non-esophageal Eosinophilic Gastrointestinal Disorders. Digestive Diseases and Sciences. 2020; 65:2024-2035.

Lindsley, AW; Schwartz, JT; Rothenberg, ME. Eosinophil responses during COVID-19 infections and coronavirus vaccination. Journal of Allergy and Clinical Immunology. 2020; 146:1-7.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 145:1549-1550.

Bousquet, J; Rothenberg, M. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 145:1549-1550.

Dunn, JL M; Shoda, T; Caldwell, JM; Wen, T; Aceves, SS; Collins, MH; Dellon, ES; Falk, GW; Leung, J; Martin, LJ; Yang, G; Furuta, GT; Rothenberg, ME; Gastrointe, CE. Esophageal type 2 cytokine expression heterogeneity in eosinophilic esophagitis in a multisite cohort. Journal of Allergy and Clinical Immunology. 2020; 145:1629-1640.e4.

Azouz, NP; Klingler, AM; Pathre, P; Besse, JA; Ben Baruch-Morgenstern, N; Ballaban, AY; Osswald, GA; Brusilovsky, M; Habel, JE; Caldwell, JM; Ynga-Durand, MA; Abonia, PJ; Hu, Y; Wen, T; Rothenberg, ME. Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis. Science Translational Medicine. 2020; 12.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 145:1350-1351.

Collins, MH; Martin, LJ; Wen, T; Abonia, JP; Putnam, PE; Mukkada, VA; Rothenberg, ME. Eosinophilic Esophagitis Histology Remission Score: Significant Relations to Measures of Disease Activity and Symptoms. Journal of Pediatric Gastroenterology and Nutrition. 2020; 70:598-603.

Oliva, S; Azouz, NP; Stronati, L; Rothenberg, ME. Recent advances in potential targets for eosinophilic esophagitis treatments. Expert Review of Clinical Immunology. 2020; 16:421-428.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 145:1134-1135.

Henderson, A; Magier, A; Schwartz, JT; Martin, LJ; Collins, MH; Putnam, PE; Mukkada, VA; Abonia, JP; Rothenberg, ME; Fulkerson, PC. Monitoring Eosinophilic Esophagitis Disease Activity With Blood Eosinophil Progenitor Levels. Journal of Pediatric Gastroenterology and Nutrition. 2020; 70:482-488.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 145:771-772.

Bitton, A; Avlas, S; Reichman, H; Itan, M; Karo-Atar, D; Azouz, NP; Rozenberg, P; Diesendruck, Y; Nahary, L; Rothenberg, ME; Benhar, I; Munitz, A. A key role for IL-13 signaling via the type 2 IL-4 receptor in experimental atopic dermatitis. Science Immunology. 2020; 5.

Avlas, S; Itan, M; Dolitzky, A; Varol, C; Rothenberg, M; Munitz, A. Intraesophageal administration of oxazolone to skin-sensitized mice results in experimental eosinophilic esophagitis‏ ‏resembling human disease. Journal of Allergy and Clinical Immunology. 2020; 145:ab41.

Mersha, T; Gautam, Y; Caldwell, J; Rothenberg, M. Genome-wide admixture and association analyses identify novel eosinophilic esophagitis-associated loci in African American ancestry. Journal of Allergy and Clinical Immunology. 2020; 145:ab42.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 145:474-475.

Kottyan, LC; Parameswaran, S; Weirauch, MT; Rothenberg, ME; Martin, LJ. The genetic etiology of eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2020; 145:9-15.

Hirano, I; Dellon, ES; Hamilton, JD; Collins, MH; Peterson, K; Chehade, M; Schoepfer, AM; Safroneeva, E; Rothenberg, ME; Falk, GW; Akinlade, B; Stahl, N; Yancopoulos, GD; Radin, A. Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis. Gastroenterology. 2020; 158:111-122.e10.

Aceves, S; Collins, MH; Rothenberg, ME; Furuta, GT; Gonsalves, N; Abonia, JP; Almonte, S; Andrews, R; Arrington, A; Arva, N; Yang, G; Zalewski, A; Zicarelli, A; Gastrointe, CE. Advancing patient care through the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Journal of Allergy and Clinical Immunology. 2020; 145:28-37.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 145:85-86.

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Host-Microbiota Interactions in the Esophagus During Homeostasis and Allergic Inflammation

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The esophagus has a unique microbiome that interacts with the developing host immune system. Disruptions to that balance, if unaddressed, may pose significant implications for long-term health. Read More