From Discovery to Development

The Advanced Leukemia Therapies and Research Center fosters research collaborations across many basic science and clinical divisions at Cincinnati Children’s.

Our goals include understanding the basic mechanisms of leukemia pathogenesis, and expediting the translational research process.

Understanding the Basic Mechanisms of Leukemia Pathogenesis

One of our top priorities is to improve our understanding of how and why MDS and AML develop. To that end, our researchers are investigating the mechanistic basis of the genetic and nongenetic factors that drive leukemia development.

We aim to enhance these efforts in a number of ways:

• Leveraging and further developing our existing strengths in mouse modeling, signaling and basic cellular mechanisms
• Harnessing the power of innovative discovery platforms such as functional genomics and next-generation mouse models

Expediting the Translational Research Process

Our unique, cross-disciplinary approach helps streamline our ability to identify novel therapeutic targets and develop safe, effective interventions.

Many of our physicians and researchers work under the same roof, making it easier to integrate basic research with our clinical leukemia programs and investigator-initiated clinical trials. Our team also has access to advanced tools and resources, including:

• The Humanized Mouse Resource Core, a facility that provides the mouse models we use to study leukemia cells in a human-like blood system
• Pre-clinical screening platforms
• Drug discovery and development tools
• Seed funding

Contact us if you’re interested in joining our research team or funding an active area of study.