Kenneth M. Kaufman, PhD
The Kaufman laboratory received two special Covid-19 grants to study the immune response to SARs-Cov2: a local grant and a national grant sponsored by the Veterans Administration.Leah C. Kottyan, PhD
Xiaoming Lu, PhD, and Xiaoting Chen, PhD, from the Kottyan and Weirauch labs published their first paper on massively parallel reporter assays in the journal Nature Communications.
Research associate Lu presented his work on massively parallel reporter assays and their application to the disease systemic lupus erythematosus at the American Society of Human Genetics 2020 conference and was a semi-finalist for the prestigious Charles J. Epstein Trainee Awards for Excellence in Human Genetics Research.
The Kottyan lab collaborated with Matthew Weirauch, PhD, and Rafi Kopan's laboratory to perform ATAC-seq as well as ChIP-seq on RBPJ, RUNX1, and RUNX2 for an important study describing the way Runx1 shapes the chromatin and transcriptional landscape in a study published in PLoS Genetics.
Matthew T. Weirauch, PhD
Lu X, Chen X, Forney C, Donmez O, Miller D, Parameswaran S, Hong T, Huang Y, Pujato M, Cazares T, Miraldi ER, Ray JP, de Boer CG, Harley JB, Weirauch MT*, Kottyan LC*. Global discovery of lupus genetic risk variant allelic enhancer activity. Nature Communications. 2021 Mar 12;12(1):1611. PMID: 33712590. *co-corresponding authors
Liu X, Hong T, Parameswaran S, Ernst K, Marazzi I, Weirauch MT*, Fuxman Bass J*. Human virus transcriptional regulators. Cell. 2020 Jul 9;182(1):24-37. doi: 10.1016/j.cell.2020.06.023. PMID: 32649876. PMCID: PMC7346790. *co-senior and co-corresponding authors
Nan Shen, MD
Shen led a study with collaborators Kottyan and Weirauch published in Nature Communications highlighting an integrated strategy to define non-coding RNA functional regulatory elements using disease-associated variants and providing novel mechanistic links between SLE non-coding risk genetic variation and disease etiology.Stephen N. Waggoner, PhD
Waggoner received the 2020 Richard Akeson Excellence in Teaching Award after receiving nominations from almost two dozen current and former trainees.
Ayad Ali, a T32-supported MSTP student in the Waggoner Lab, won a 2020 Albert J. Ryan Foundation Fellowship and 2021 Presidential Medal of Graduate Student Excellence Award prior to defending his PhD in Immunology in May 2021.
Waggoner joined the HIVD study section as a standing member in July 2020 for a four-year term. He also participates in multiple NIH study sections reviewing grant proposals concerning the COVID-19 pandemic.
The Waggoner lab received an NIAID R21 to use collaborative cross mice to study the genetics underlying heterogeneity of organ damage in lupus.
Our lab filed a patent describing new technology for targeting pathogenic cells in autoimmune disease that express high levels of the receptor PD-1 (based on our 2020 paper by Seth Reighard in Cell Reports Medicine).
Reighard, a MSTP and Immunology PhD student in the Waggoner lab, published a paper in Cytotherapy concerning the perils of using cytokine-based therapies to expand immunoregulatory cytotoxic lymphocytes in mice with lupus-like disease.
Ivayla Gyurova finished her PhD studies in the Waggoner lab and moved to San Francisco to work for Sana Biotechnology.
