Gravholt, CH; Andersen, NH; Conway, GS; Dekkers, OM; Geffner, ME; Klein, KO; Lin, AE; Mauras, N; Quigley, CA; Rubin, K; Sandberg, DE; Sas, TCJ; Silberbach, M; Soderstrom-Anttila, V; Stochholm, K; van Alfen-van derVelden, JA; Woelfle, J; Backeljauw, PF; Grp, I. Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting. European Journal of Endocrinology. 2017; 177(3):G1-G70.
This paper establishes clinical practice guidelines for care of girls and women with Turner syndrome developed at the 2016 Cincinnati International Turner Syndrome meeting.
Davidson, WS; Heink, A; Sexmith, H; Dolan, LM; Gordon, SM; Otvos, JD; Melchior, JT; Elder, DA; Khoury, J; Geh, E; Shah, AS. Obesity is associated with an altered HDL subspecies profile among adolescents with metabolic disease. Journal of lipid research. 2017; 58(9):1916-1923.
This paper establishes that obesity is the major risk factor associated with the altered HDL subspecies profile previously reported in adolescents with T2D, with smaller contributions from insulin resistance and diabetes.
Sanchez-Gurmaches, J; Tang, Y; Jespersen, NZ; Wallace, M; Calejman, C; Gujja, S; Li, H; Edwards, YJK; Wolfrum, C; Metallo, CM; Nielsen, S; Scheele, C; Guertin, DA. Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis. Cell Metabolism. 2018; 27(1):195-209.e6.
The regulation and function of adipocyte de novo lipogenesis and its association with thermogenesis are not understood. This paper provides evidence suggesting that AKT2 drives de novo lipogenesis in adipocytes by stimulating ChREBPβ transcriptional activity and that cold induces the AKT2-ChREBP pathway in BAT to optimize fuel storage and thermogenesis. These data provide insight into adipocyte de novo lipogenesis regulation and function and illustrate the metabolic flexibility of thermogenesis.
Redel, JM; DiFrancesco, M; Vannest, J; Altaye, M; Beebe, D; Khoury, J; Dolan, LM; Lee, G; Brunner, H; Holland, S; Brady, C; Shah, AS. Brain gray matter volume differences in obese youth with type 2 diabetes: a pilot study. Journal of Pediatric Endocrinology and Metabolism. 2018; 31(3):261-268.
This paper identified global and regional differences in brain gray matter volume between obese youth with T2D and healthy controls. This cross-sectional study raises the possibility that the brain may be susceptible to end-organ effects of obesity and/or T2D in adolescents.
Smego, A; Lawson, S; Courter, JD; Warden, D; Corathers, S. Decreasing the Time to Insulin Administration for Hospitalized Patients With Cystic Fibrosis-Related Diabetes. Hospital pediatrics. 2018; 8(5):288-292.
This paper provides a blue print for hospital units to promptly administer rapid acting insulin while reducing untoward effects associated with insulin administration.