Like most U.S. hospitals, Cincinnati Children's is affected by the IV fluid shortage caused by damage to Baxter International's North Carolina production facility during Hurricane Helene. Our teams will continue to watch this situation and will provide any updates as needed.
Obesity is a significant health problem. Results from the current study, together with published data from our laboratory, suggest that obesity is detrimental during murine sepsis. In this study, we found that obesity affects cardiac function and leads to cardiac injury after sepsis. The mechanism of myocardial injury is, in part, through activation of the STAT3 pathway.
This is the first manuscript reporting that hyperchloremia is an independent risk factor for mortality among children with septic shock. Since hyperchloremia is a modifiable clinical variable, the study has the potential to positively change clinical practice.
This manuscript reports a new and improved stratification model for pediatric septic shock that includes both protein and mRNA biomarkers. The stratification model has the potential to serve as a reliable prognostic enrichment tool to enable precision critical care medicine for children with septic shock.
This manuscript reports a new stratification model for pediatric acute respiratory distress syndrome (PARDS). The stratification model has the potential to serve as a reliable prognostic enrichment tool to enable precision critical care medicine for children with PARDS.