About

Biography

As a pediatric hematologist, I specialize in disorders of bleeding and blood clotting. I treat children and adolescents with conditions such as hemophilia, von Willebrand disease and disordered menstrual bleeding. I often see patients in the Young Women’s Bleeding Disorder Clinic and the Hemophilia Treatment Center.

I was inspired to pursue my career by my family’s general practitioner, Dr. Cash, who was an exemplary model of how to take care of patients. During medical school at University of Missouri, I was drawn to hematology/oncology because of the science involved in this specialty. I chose pediatrics because I discovered and appreciate that children are much more responsive to following their care plan than adults.

Dr. Bob Janco encouraged my interest in hematology and blood clotting disorders during my residency at Vanderbilt University Medical Center. My fellowship at Cincinnati Children’s Hospital included mentoring by Dr. Ralph Gruppo and Dr. Jay Degen, who pointed me in the direction of my current position.

In addition to treating patients, I perform research. My team and I are examining the impact of blood clotting factors on neurologic disease – diseases of the brain, spinal cord and nerves. We have found that blood clotting plays a key role in the progression of multiple sclerosis, and we hope to find ways to intervene in this disease process.

MD: University of Missouri, Columbia, MO.

Residency: Vanderbilt University Medical Center, Nashville, TN, 2001-2004.

Fellowship: Pediatric Hematology / Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2004-2007; Pediatric Hemostasis Fellowship, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2007-2008; Chief Fellow, Pediatric Hematology / Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2007-2008.

Board Certifications: Pediatrics, 2004-Present; Pediatric Hematology/Oncology, 2009-Present.

Interests

Care of children and adolescents with bleeding and thrombotic disorders; hemophilia; von Willebrand disease; Young Women’s Bleeding Disorder Clinic; disordered menstrual bleeding; Hemophilia Treatment Center

Services and Specialties

Cancer and Blood Diseases, Thrombosis, Hemophilia

Interests

Interaction of coagulation factors with immunity and inflammation; inflammatory diseases; multiple sclerosis; sickle cell disease; mouse models of these diseases; coagulation factor knockouts; how hemostatic factors modify the inflammatory response

Research Areas

Hematology, Cancer and Blood Diseases

Insurance Information

Cincinnati Children's strives to accept a wide variety of health plans. Please contact your health insurance carrier to verify coverage for your specific benefit plan.

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Publications

Selected

Plasmin-mediated fibrinolysis enables macrophage migration in a murine model of inflammation. Silva, LM; Lum, AG; Tran, C; Shaw, MW; Gao, Z; Flick, MJ; Moutsopoulos, NM; Bugge, TH; Mullins, ES. Blood. 2019; 134:291-303.

Selected

Abnormal Uterine Bleeding in Adolescent Women. Mullins, ES; Miller, RJ; Mullins, TL K. Current Pediatrics Reports. 2018; 6:123-131.

Selected

Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease. Shaw, MA; Gao, Z; McElhinney, KE; Thornton, S; Flick, MJ; Lane, A; Degen, JL; Ryu, JK; Akassoglou, K; Mullins, ES. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2017; 37:3776-3788.

Selected

Extended half-life pegylated, full-length recombinant factor VIII for prophylaxis in children with severe haemophilia A. Mullins, ES; Stasyshyn, O; Alvarez-Roman, MT; Osman, D; Liesner, R; Engl, W; Sharkhawy, M; Abbuehl, BE. Haemophilia. 2017; 23:238-246.

Selected

Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice. Shaw, MA; Kombrinck, KW; McElhinney, KE; Sweet, DR; Flick, MJ; Palumbo, JS; Cheng, M; Esmon, NL; Esmon, CT; Brill, A; Wagner, DD; Degen, JL; Mullins, ES. Blood. 2016; 128:721-731.

Selected

Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice. Arumugam, PI; Mullins, ES; Shanmukhappa, SK; Monia, BP; Loberg, A; Shaw, MA; Rizvi, T; Wansapura, J; Degen, JL; Malik, P. Blood. 2015; 126:1844-1855.

Selected

Evaluation and Management of Adolescents with Abnormal Uterine Bleeding. Mullins, TL K; Miller, RJ; Mullins, ES. Pediatric Annals: a journal of continuing pediatric education. 2015; 44:e218-e222.

Selected

Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain. Mullins, ES; Kombrinck, KW; Talmage, KE; Shaw, MA; Witte, DP; Ullman, JM; Degen, SJ; Sun, W; Flick, MJ; Degen, JL. Blood. 2009; 113:696-704.

Thrombotic risk associated with gender-affirming hormone therapy. Mullins, TL K; Mullins, ES. Journal of Thrombosis and Haemostasis. 2024; 22:2129-2139.

From the Blog

Know the Symptoms and Risk Factors of Thrombosis in Kids
Blog Cancer and Blood Diseases

Know the Symptoms and Risk Factors of Thrombosis in Kids

By Eric Mullins, MD10/13/2023

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4.6
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