Lin Fei, PhD

Professor, UC Department of Pediatrics

lin.fei@cchmc.org

About

Biography

As a professor and researcher, I design clinical and non-clinical studies, perform data analysis and presentation and examine mathematical modeling. My primary interests are probability and statistical theory applied to medical research, including distributional theory and optimization.

My interest in this field stems from my mathematical and statistical training and quantitative research. One of my notable discoveries is the probabilistic relationship between sample size and discovery rate in clinical studies, which can be reviewed in some of my publications.

I have been a researcher for over 29 years and began working with Cincinnati Children’s in 2012.

Interests

Statistics; ranking and selection; sequential testing; multiple comparisons; probability modeling; stochastic process inference

Research Areas

Biostatistics and Epidemiology

Publications

One-food versus 4-food elimination diet for pediatric eosinophilic esophagitis: A multisite randomized trial. Kliewer, KL; Abonia, JP; Aceves, SS; Atkins, D; Bonis, PA; Capocelli, KE; Chehade, M; Collins, MH; Dellon, ES; Fei, L; Sun, Q; Wechsler, JB; Yang, GY; Rothenberg, ME. Journal of Allergy and Clinical Immunology. 2025; 155:S0091-6749(24)00907-2.

Liberal Fluid Resuscitation is Associated with Improved Outcomes in Pediatric Acute Pancreatitis. Norris, N; Farrell, P; Ibrahim, S; Fei, L; Sun, Q; Vitale, DS; Abu-El-Haija, M. The Journal of Pediatrics. 2025; 276:114329.

Longitudinal Links between Changes in Body Composition and Liver Disease Severity in Children and Adolescents with Metabolic Dysfunction-Associated Steatotic Liver Disease. Speakman, A; Hitchcock, K; Romantic, E; Quiambao, V; Lepolt, A; Ley, S; Arce-Clachar, AC; Bramlage, K; Fei, L; Sun, Q; Xanthakos, S; Mouzaki, M. The Journal of Pediatrics. 2025; 276:114301.

MRI and Blood-based Biomarkers Are Associated With Surgery in Children and Adults With Ileal Crohn's Disease. Dillman, JR; Tkach, JA; Fletcher, JG; Bruining, DH; Lu, A; Kugathasan, S; Alazraki, AL; Knight-Scott, J; Stidham, RW; Adler, J; Anton, CG; Imbus, RA; Dudley, JA; Denson, LA. Inflammatory Bowel Diseases. 2024; 30:2181-2190.

S800 Auricular Neurostimulation Improves Abdominal Pain, Nausea, Psychological Functioning, and Sleep in Patients Over 18 Years of Age. VonAxelson, A; Santucci, N; Waheed, U; El-Chamas, K; Graham, K; Hardy, J; Miller, M; Sahay, R; Fei, L. The American Journal of Gastroenterology (Elsevier). 2024; 119:s552.

Predictors of celiac disease in patients with type 1 diabetes and positive tissue transglutaminase immunoglobulin A. Rutsky, J; Krueger, A; Sun, Q; Fei, L; Mallon, D. Journal of Pediatric Gastroenterology and Nutrition. 2024; 79:622-630.

Perioperative management protocol for pediatric endoluminal functional lumen imaging probe in esophageal motility disorders. Mansi, S; Dorfman, L; El-Chammas, K; Santucci, N; Graham, K; Fei, L; Wittkugel, E; Levi, S; Kaul, A. Journal of Pediatric Gastroenterology and Nutrition. 2024; 79:746-751.

Diagnostic accuracy of serum matrix metalloproteinase-7 as a biomarker of biliary atresia in a large North American cohort. Pandurangi, S; Mourya, R; Nalluri, S; Fei, L; Dong, S; Harpavat, S; Guthery, SL; Molleston, JP; Rosenthal, P; Sokol, RJ; Shneider, BL; Horslen, SP; Teckman, JH; Bezerra, JA. Hepatology. 2024; 80:152-162.

High prevalence of gastrointestinal disorders in a large cohort of patients with joint hypermobility. Sood, V; Kaul, A; El-Chammas, KI; Mukkada, VA; Sun, Q; Fei, L; Santucci, NR. Journal of Pediatric Gastroenterology and Nutrition. 2024; 79:42-47.

Exploring Diagnostic Priorities: The Role of Colonic Manometry in Evaluating Pediatric Patients with Intractable Idiopathic Constipation Prior to Sacral Nerve Stimulation. Dorfman, L; El-Chammas, K; Singh, A; Fei, L; Mansi, S; Santucci, NR; Kaul, A. Children. 2024; 11:768.