Precision Diagnosis for Managing Recurrent Respiratory Papillomatosis

Why is this test done, and how does it help doctors manage papillomatosis?

Recurrent respiratory papillomatosis (RRP) is most frequently caused by low-risk HPV-6 and HPV-11. Therefore, HPV detection in patient biopsies aids in the diagnosis of RRP. HPV strain has been shown to predict RRP severity, with HPV-11 positive disease being associated with an increased need for surgical intervention and a higher risk of progression to malignancy. This HPV-6/HPV-11 test is a clinically approved test performed in a CLIA-certified, CAP-accredited laboratory. Thus, the test results can be used to guide patient management.

How does the HPV test work?

The HPV test is performed on biopsy tissue specimens that have been reviewed by a pathologist. Ultra-high sensitivity droplet digital PCR (ddPCR) platform is used to test for both the presence of HPV-6 and HPV-11 viruses separately in the same specimen. Low levels of infection in respiratory papillomas can be identified using this test. For additional information about the test, read the information sheet.

Do I need another surgery for this test?

No. This HPV test can be performed on the same biopsy tissue specimen that was used for the initial pathologic diagnosis. If the diagnosis was established on tissue that was obtained in the past, this test can also be performed on the previously obtained tissue.

How can my doctor request this test?

It is simple. Your doctor can complete this requisition form and send it along with paraffin tissue block or slides to the MGPS laboratory. The test information link above will provide your doctor with detailed information on how to send the sample.