What will happen in the study?

This study includes 4 study visits over a 5 month period and a telephone contact prior to each study visit.

Participants will be randomized (selection random like flipping a coin) to receive 1 of 3 doses of a prebiotic or a placebo (looks like the supplement but does not contain the prebiotic). The study supplement will be in a single dose packet, and you will take the study supplement once per day in the morning with water.

Throughout the study, we will review your electronic medical record to obtain any relevant information such as medical history, medication changes, etc.

Here are some of the other things that will happen in this study:

You will:

• Submit saliva and blood samples
• If female and having a menstrual cycle, have a pregnancy test
• Submit symptom questionnaires to report any symptoms related to your IBD
• Complete quality of life questionnaires
• Have physical exams
• Submit stool samples (can be collected at home with a stool collection kit we will give you)
• Be asked to report what you have eaten in the past 24 hours either over the phone or at a study visit at an unannounced day and time
• Be asked to report any symptoms such as stomach pain and diarrhea while taking the prebiotic/placebo using the GSRS (Gastrointestinal Symptom Rating Scale) symptom questionnaire.

We will ask you to record each daily dose of the study supplement.

You will be given a consent form that thoroughly explains all of the details of the study. A member of the study staff will review the consent form with you and will be sure that all of your questions are answered.