What will happen in the study?

In these studies, children who are eligible to participant will start their growth hormone treatment through the study and be required to attend on-site study visits about every 3 months. Each visit lasts about 2-3 hours on average.

In the first year of the study, children are assigned either the FDA approved daily growth hormone medication or the study medication (once weekly long-acting growth hormone medication). After a period of one year in the study, all children taking the daily growth hormone medication will start taking the once weekly long-acting medication.

Participants will:

• Have blood drawn at multiple visits (some of them will require fasting).
• Have height, weight, body composition and vital signs (blood pressure, breathing rate, heart rate) taken.
• Have physical exams performed by the study doctor (some will include an exam to check for signs of puberty).
• Have electrocardiograms (ECG) or echocardiograms (TTE) performed at some of the visits depending on your diagnosis.
• Have x-rays taken of their hand.
• Be trained on the use and care of the study medication (daily or weekly).
• Be required to log their daily or weekly injections into a study app on a cell phone
• Complete study questionnaires.

Families interested in having their child participate will be given a consent form that thoroughly explains all of the details of the study. A member of the study staff will review the consent form with you and will be sure that all of your questions are answered at the first study visit.