What will happen in the study?

The study involves a full day visit to Cincinnati Children’s, plus an optional extra visit.

The following is a list of procedures that may take place during the study:

• An initial health screening
• Reading/math related questions
• Parent questionnaires about behavior
• MRI brain scan for research: a procedure which allows us to look at the brain’s structure and the level of important chemicals, including neurotransmitters
• Transcranial Magnetic Stimulation (TMS): a procedure which activates the brain so we can measure how it controls movements
• Computer games and tests of coordination
• Optional extra visit: participants will be given a small dose of a carbidopa/levodopa (sinemet®) pill or placebo (a pill that looks like the study drug but contains no medication), which is converted by the body to dopamine (dopamine is made naturally in the brain and is important for attention and motivation)

Parents interested in having their child participate will be emailed/mailed/given a consent form that thoroughly explains all of the details of the study. The form covers all of the procedures, the risks, the benefits, the pay, who to contact with questions or concerns and more. A member of the study staff will review the consent form with you and will be sure that all of your questions are answered. Study procedures will not begin until a parent or guardian has signed this form and, if of age, the child has given at minimum his/her verbal agreement.