Innovation Ventures Search Results

Autologous cell and gene therapy for Gaucher Disease

Therapy for neuronopathic Gaucher Disease using gene therapy and a specialized neuronal lineage iPS cell that facilitates entry to and engraftment in the brain.

Bivalent VLP Ebola Vaccine

Bi-valent spherical virus like particle (VLP) vaccine against Ebola virus.

Human Natural Killer cells expressing chimeric antigen receptor that targets aberrant immune system signaling that is involved in auto-antibody production associated with Systemic Lupus Erythematosus.

Combination Therapy for Leukemia and Solid Tumors

A pharmaceutical therapy that has demonstrated, in vivo, the ability to eliminate leukemic, lung adenocarcinoma and lung squamous carcinoma cells.

Complement 5a increases inflammation in Hunter Syndrome

Methods for treating inflammation and autoimmune disease.

Microbiota-derived retinoid boosts immunity

Probiotic bacteria strains increase infection resistance.

Novel Small Molecule RAC-Pathway Inhibitor for the Treatment of Cancer

Our proprietary inhibitor binds to VAV3 thereby inhibiting the activation of RAC downstream of several oncogenes.

Rapid reliable method for collection of keratinocyte RNA and DNA samples from children.

Rapid reliable method for collection of keratinocyte RNA, DNA, microbiome, proteins, lipids, and metabolites.

Repurposing Barasertib for Idiopathic Pulmonary Fibrosis

Repurposing a phase I/II compound (AURKB inhibitor - barasertib) for idiopathic pulmonary fibrosis therapy.

Restoring acid-β-glucosidase activity by non-inhibitory small molecule chaperones

Restore GCase activity in the brain for Gaucher and Parkinson's

Serine Protease Inhibitors (SPINK7) for Treatment of EoE

Deficiency of SPINK7 is a novel regulator of pro-inflammatory cytokine production in eosinophilic esophagitis.

Small Molecule Inhibitors for Treating Demyelinating Diseases

Small molecules, targeting HDAC3, enhance myelin repair in demyelinating diseases and injuries

Small molecule perforin inhibitors to enhance vaccine efficacy

Perforin inhibition during vaccination can improve vaccine success against a variety of infections and diseases for which sufficiently efficacious immune response has proven difficult

Stem Cell & Organoid Medicine

Organoids provide an unprecedented opportunity to study human organ development and physiology, and investigate the cause of disease.

Targeted inhibition of UBE2N as a therapeutic approach in myeloid malignancies

Pharmacologic and genetic inhibition of UBE2N suppresses the function and viability of MDS/AML cells lines and patient samples. A commercially available and a novel compound has been identified.

Targeting NTRK1 for Treatment of Allergic Inflammatory Conditions

Pharmacological targeting of NTRK1 using small molecule inhibitors may reduce allergic inflammation.

Therapeutic Inhibition of the WT1-MYCN-PLK1 Axis for Treatment of Idiopathic Pulmonary Fibrosis (IPF)

Repurposing Volasertib, a potent PLK1 inhibitor, as a treatment of Idiopathic Pulmonary Fibrosis

Therapeutic Prevention of Obesity in At-Risk Populations

A method to prevent or treat diet-induced obesity and/or the associated co-morbidities in an at-risk population.

Therapeutic Protein Delivery Across the Blood-Brain Barrier

A delivery mechanism which allows large molecule therapeutics to trancytose the blood-brain barrier for treatment of neurological disorders.

Thrombin Inhibitor as Novel Oral Treatment for Atopic Dermatitis

A newly established link between the mechanistic role of thrombin and fibrinogen and their contribution to AD provides a novel mechanism for oral treatment.

Using Dantrolene to Treat Neuronopathic Gaucher Disease

Dantrolene is an antagonist of ryanodine receptors (Ryrs) and blocks Ryr-mediated endoplasmic reticulum calcium release. It is an FDA-approved drug.

Innovation Ventures
Innovation Ventures Search Results

Results (22)