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Results (44)
Autologous cell and gene therapy for Gaucher Disease
Therapy for neuronopathic Gaucher Disease using gene therapy and a specialized neuronal lineage iPS cell that facilitates entry to and engraftment in the brain.
Automated Clinical Trial Screening Eligibility Software Algorithm
Structured and natural language processing techniques used to match patients to clinical trials from EHR data.
Automated Risk Assessment (ARIA) for School Violence Prevention
An innovative AI-based system for early detection and prevention of school violence through automated risk assessment.
Biomarker Response Signatures of Children Receiving Infliximab for Crohn’s Disease
Plasma Proteomic Response Signature of Children Receiving Infliximab for Crohn’s Disease
Bivalent VLP Ebola Vaccine
Bi-valent spherical virus like particle (VLP) vaccine against Ebola virus.
Brain Function Mapping with Intracranial SEEG Using Event-related Spectral Modulations
This SEEG-based technique offers a safer, more precise method for functional brain mapping.
CAR-NK Therapy for Lupus
Human Natural Killer cells expressing chimeric antigen receptor that targets aberrant immune system signaling that is involved in auto-antibody production associated with Systemic Lupus Erythematosus.
Clinical Pharmacology Discovery Platform
Novel Approach to datamining and synthesizing Information from very large drug, disease, and adverse effects databases
Combination Therapy for Leukemia and Solid Tumors
A pharmaceutical therapy that has demonstrated, in vivo, the ability to eliminate leukemic, lung adenocarcinoma and lung squamous carcinoma cells.
Comprehensive Method to Package mRNA Gene Therapies, Vaccines and Protein Replacement Therapies
Comprehensive method to package mRNA gene therapies, vaccines and protein replacement therapies
Dosing Algorithm for Inhibitors of Complement-Mediated Activity
A validated algorithm to calculate when the next dose of an inhibitor of complement-mediated (C5) activity is required.
Elevated Oncostatin M Predicts Non-response to Anti-TNF Therapy
Oncostatin M biomarkers are associated with non-response to Infliximab therapy
Learning Health Networks: Integrated Technologies for a Learning Healthcare System
A suite of technologies designed to realize the vision of a Learning Healthcare System, complemented by an innovative agent-based model.
Methods for treating inflammation and autoimmune disease.
Methods for treating inflammation and autoimmune disease.
Microbiota-derived retinoid boosts immunity
Probiotic bacteria strains increase infection resistance.
Morcellator for use with Feeding Tubes
A prototype of a self-contained morcellator for preparing medication for feeding tube delivery
Multi-Biomarker Panel for Reliable Detection of Septic Shock
A novel means to quickly and accurately predict the risk of death for both children and adults with septic shock.
Multi-Frequency Encoded Source Imaging
A new imaging technology to localize and visualize electrical and/or magnetic signals in two or more frequency ranges.
Non-Invasive Eosinophilic Gastritis Diagnostic
Non-Invasive Eosinophilic Gastritis Diagnostic
Non-invasive diagnostic test for Eosinophilic Esophagitis
A non-invasive method for Eosinophilic diagnosis and monitoring using buccal membrane biomarkers
Novel Small Molecule RAC-Pathway Inhibitor for the Treatment of Cancer
Our proprietary inhibitor binds to VAV3 thereby inhibiting the activation of RAC downstream of several oncogenes.
Personalized Pain Management Diagnostic
A method of identifying genetic variants that affect acute treatment for acute pain.
Polymer-based product streamlines population cell analysis
Single cell labeling method to aid in applied medicine and drug development
Predicting Preterm Infants' Cognitive and Language Outcomes
Quantitatively identifying diffuse white matter anomalies using MRI as a systematic approach provides early identification of the need for developmental deficit interventions in preterm infants.
Rapid reliable method for collection of keratinocyte RNA and DNA samples from children.
Rapid reliable method for collection of keratinocyte RNA, DNA, microbiome, proteins, lipids, and metabolites.
Repurposing Barasertib for Idiopathic Pulmonary Fibrosis
Repurposing a phase I/II compound (AURKB inhibitor - barasertib) for idiopathic pulmonary fibrosis therapy.
Restoring acid-β-glucosidase activity by non-inhibitory small molecule chaperones
Restore GCase activity in the brain for Gaucher and Parkinson's
Serine Protease Inhibitors (SPINK7) for Treatment of EoE
Deficiency of SPINK7 is a novel regulator of pro-inflammatory cytokine production in eosinophilic esophagitis.
Serum Biomarkers and Algorithm of Lung Decline in Cystic Fibrosis
Novel serum protein biomarkers and functional data analysis-based algorithm used to develop a predictive test for lung function decline.
Small Molecule Inhibitors for Treating Demyelinating Diseases
Small molecules, targeting HDAC3, enhance myelin repair in demyelinating diseases and injuries
Small molecule perforin inhibitors to enhance vaccine efficacy
Perforin inhibition during vaccination can improve vaccine success against a variety of infections and diseases for which sufficiently efficacious immune response has proven difficult
Spherical implant to improve surgical outcomes for patients with esophageal Atresia
Spheric endo-luminal traction device helps improve surgical outcomes for individuals with long-gap esophageal atresia
Spreading Activation Methodology (SAM) for Differentiating Patients Using Speech
A diagnostic, prognostic, and patient monitoring algorithm that compares text and speech characteristics to a corpus to distinguish patients; validated in suicidal vs. non-suicidal adolescents and epilepsy surgery prediction.
Stem Cell & Organoid Medicine
Organoids provide an unprecedented opportunity to study human organ development and physiology, and investigate the cause of disease.
TOPS is an online family problem-solving treatment for pediatric traumatic brain injury (TBI)
TOPS is an online family problem-solving treatment for pediatric traumatic brain injury (TBI)
Targeted inhibition of UBE2N as a therapeutic approach in myeloid malignancies
Pharmacologic and genetic inhibition of UBE2N suppresses the function and viability of MDS/AML cells lines and patient samples. A commercially available and a novel compound has been identified.
Targeting NTRK1 for Treatment of Allergic Inflammatory Conditions
Pharmacological targeting of NTRK1 using small molecule inhibitors may reduce allergic inflammation.
Therapeutic Inhibition of the WT1-MYCN-PLK1 Axis for Treatment of Idiopathic Pulmonary Fibrosis (IPF)
Repurposing Volasertib, a potent PLK1 inhibitor, as a treatment of Idiopathic Pulmonary Fibrosis
Therapeutic Prevention of Obesity in At-Risk Populations
A method to prevent or treat diet-induced obesity and/or the associated co-morbidities in an at-risk population.
Therapeutic Protein Delivery Across the Blood-Brain Barrier
A delivery mechanism which allows large molecule therapeutics to trancytose the blood-brain barrier for treatment of neurological disorders.
Thrombin Inhibitor as Novel Oral Treatment for Atopic Dermatitis
A newly established link between the mechanistic role of thrombin and fibrinogen and their contribution to AD provides a novel mechanism for oral treatment.
Urinary Protein Biomarker Assay for Idiopathic Nephrotic Syndrome
Biomarker panel for distinguishing idiopathic steroid resistant vs. steroid sensitive nephrotic syndrome.
Using Dantrolene to Treat Neuronopathic Gaucher Disease
Dantrolene is an antagonist of ryanodine receptors (Ryrs) and blocks Ryr-mediated endoplasmic reticulum calcium release. It is an FDA-approved drug.
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