DasGupta Lab

Publications

Muraleedharan, R; Dasgupta, B. AMPK in the brain: its roles in glucose and neural metabolism. FEBS Journal. 2022; 289:2247-2262.

Oatman, N; Dasgupta, N; Arora, P; Choi, K; Gawali, MV; Gupta, N; Parameswaran, S; Salomone, J; Reisz, JA; Lawler, S; Weirauch, MT; D'Alessandro, A; Komurov, K; Dasgupta, B. Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer. Science Advances. 2021; 7:eabd7459.

Muraleedharan, R; Gawali, MV; Tiwari, D; Sukumaran, A; Oatman, N; Anderson, J; Nardini, D; Bhuiyan, MA N; Tkac, I; Ward, AL; Gross, C; Rao, R; Schirmeier, S; Dasgupta, B. AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival. Cell Reports. 2020; 32:108092.

Chhipa, RR; Fan, Q; Anderson, J; Muraleedharan, R; Huang, Y; Ciraolo, G; Chen, X; Waclaw, R; Chow, LM; Khuchua, Z; Nakano, I; Dasgupta, N; Komurov, K; Dasgupta, B. AMP kinase promotes glioblastoma bioenergetics and tumour growth. Nature Cell Biology. 2018; 20:823-835.

Anderson, JL; Muraleedharan, R; Oatman, N; Klotter, A; Sengupta, S; Waclaw, RR; Wu, J; Drissi, R; Miles, L; Raabe, EH; Chow, LM; Hoffman, L; Dewire, M; Dasgupta, B. The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas. Neuro-Oncology. 2017; 19:1068-1078.

Dasgupta, B; Chhipa, RR. Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer. Trends in Pharmacological Sciences. 2016; 37:192-206.

Kim, S; Ezhilarasan, R; Phillips, E; Gallego-Perez, D; Sparks, A; Taylor, D; Ladner, K; Furuta, T; Sabit, H; Chhipa, R; DasGupta, B; Goidts, V; Bhat, KP; Nakano, I. Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner. Cancer Cell. 2016; 29:201-213.

Liu, X; Chhipa, RR; Nakano, I; Dasgupta, B. The AMPK inhibitor compound C is a potent AMPK-independent antiglioma agent. Molecular Cancer Therapeutics. 2014; 13:596-605.

Liu, X; Chhipa, RR; Pooya, S; Wortman, M; Yachyshin, S; Chow, LM L; Kumar, A; Zhou, X; Sun, Y; Quinn, B; Norga, K; Viollet, B; Grabowski, GA; Dasgupta, B. Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK. Proceedings of the National Academy of Sciences of USA. 2014; 111:E435-E444.

Karkare, S; Chhipa, RR; Anderson, J; Liu, X; Henry, H; Gasilina, A; Nassar, N; Roychoudhury, J; Clark, JP; Kumar, A; Pauletti, GM; Ghosh, PK; Dasgupta, B. Direct inhibition of retinoblastoma phosphorylation by nimbolide causes cell-cycle arrest and suppresses glioblastoma growth. Clinical Cancer Research. 2014; 20:199-212.

Desai, PB; Karve, AS; Zawit, M; Arora, P; Dave, N; Awosika, J; Li, N; Fuhrman, B; Medvedovic, M; Sallans, L; Zuccarello, M; Chaudhary, R; Sengupta, S; Wise-Draper, TM. A Phase 0/I Pharmacokinetic and Pharmacodynamics and Safety and Tolerability Study of Letrozole in Combination with Standard Therapy in Recurrent High-Grade Gliomas. Clinical Cancer Research. 2024; 30:2068-2077.

Karve, AS; Desai, JM; Dave, N; Wise-Draper, TM; Gudelsky, GA; Phoenix, TN; DasGupta, B; Sengupta, S; Plas, DR; Desai, PB. Potentiation of temozolomide activity against glioblastoma cells by aromatase inhibitor letrozole. Cancer Chemotherapy and Pharmacology. 2022; 90:345-356.

Desai, JM; Karve, AS; Gudelsky, GA; Gawali, MV; Seibel, W; Sallans, L; DasGupta, B; Desai, PB. Brain pharmacokinetics and metabolism of the AMP-activated protein kinase selective inhibitor SBI-0206965, an investigational agent for the treatment of glioblastoma. Investigational New Drugs. 2022; 40:944-952.

Muraleedharan, R; Dasgupta, B. AMPK in the brain: its roles in glucose and neural metabolism. FEBS Journal. 2022; 289:2247-2262.

Muraleedharan, R; Nardini, D; Waclaw, RR; Dasgupta, B. Analysis of reactive astrogliosis in mouse brain using in situ hybridization combined with immunohistochemistry. STAR Protocols. 2021; 2:100375.

Oatman, N; Dasgupta, N; Arora, P; Choi, K; Gawali, MV; Gupta, N; Parameswaran, S; Salomone, J; Reisz, JA; Lawler, S; Weirauch, MT; D'Alessandro, A; Komurov, K; Dasgupta, B. Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer. Science Advances. 2021; 7:eabd7459.

Golan, K; Singh, AK; Kollet, O; Bertagna, M; Althoff, MJ; Khatib-Massalha, E; Petrovich-Kopitman, E; Wellendorf, AM; Massalha, H; Levin-Zaidman, S; Gawali, MV; Dasgupta, B; Lapidot, T; Cancelas, JA. Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma. Blood. 2020; 136:2607-2619.

Muraleedharan, R; Gawali, MV; Tiwari, D; Sukumaran, A; Oatman, N; Anderson, J; Nardini, D; Bhuiyan, MA N; Tkac, I; Ward, AL; Gross, C; Rao, R; Schirmeier, S; Dasgupta, B. AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival. Cell Reports. 2020; 32:108092.

Sukumaran, A; Choi, K; Dasgupta, B. Insight on Transcriptional Regulation of the Energy Sensing AMPK and Biosynthetic mTOR Pathway Genes. Frontiers in Cell and Developmental Biology. 2020; 8:671.