Skelton Lab

Publications

Disdier, C; Lhotellier, C; Guyot, AC; Costa, N; Théodoro, F; Pruvost, A; Skelton, MR; Joudinaud, T; Mabondzo, A; Bénech, H. Dodecyl creatine ester, a promising treatment to deliver creatine to neurons, achieves pharmacology efficacy in creatine transporter deficiency. European Journal of Medicinal Chemistry. 2025; 284:117195.

Disdier, C; Soyer, A; Broca-Brisson, L; Goutal, S; Guyot, AC; Ziani, N; Breuil, L; Winkeler, A; Hugon, G; Joudinaud, T; Harati, R; Hamoudi, RA; Tournier, N; Mabondzo, A. Impaired brain glucose metabolism as a biomarker for evaluation of dodecyl creatine ester in creatine transporter deficiency: Insights from patient brain-derived organoids and in vivo [18F]FDG PET imaging in a mouse model. Neurobiology of Disease. 2024; 202:106720.

Sugimoto, C; Perna, MK; Regan, SL; Tepe, EA; Liou, R; Fritz, AL; Williams, MT; Vorhees, CV; Skelton, MR. A Gad2 specific Slc6a8 deletion recapitulates the contextual and cued freezing deficits seen in Slc6a8-/y mice. Brain Research. 2024; 1825:148690.

Broca-Brisson, L; Harati, R; Disdier, C; Mozner, O; Gaston-Breton, R; Maïza, A; Costa, N; Guyot, A; Sarkadi, B; Apati, A; Yates, F; Armengaud, J; Hamoudi, R; Mabondzo, A. Deciphering neuronal deficit and protein profile changes in human brain organoids from patients with creatine transporter deficiency. eLife. 2023; 12.

Broca-Brisson, L; Harati, R; Disdier, C; Mozner, O; Gaston-Breton, R; Maïza, A; Costa, N; Guyot, AC; Sarkadi, B; Apati, A; Yates, F; Armengaud, J; Hamoudi, R; Mabondzo, A. Deciphering neuronal deficit and protein profile changes in human brain organoids from patients with creatine transporter deficiency. eLife. 2023; 12:RP88459.

Mabondzo, A; Harati, R; Broca-Brisson, L; Guyot, AC; Costa, N; Cacciante, F; Putignano, E; Baroncelli, L; Skelton, MR; Saab, C; Joudinaud, T; Gaillard, JC; Armengaud, J; Hamoudi, R. Dodecyl creatine ester improves cognitive function and identifies key protein drivers including KIF1A and PLCB1 in a mouse model of creatine transporter deficiency. Frontiers in Molecular Neuroscience. 2023; 16:1118707.

Krikorian, R; Skelton, MR; Summer, SS; Shidler, MD; Sullivan, PG. Blueberry Supplementation in Midlife for Dementia Risk Reduction. Nutrients. 2022; 14:1619.

Hall, CH T; Lee, JS; Murphy, EM; Gerich, ME; Dran, R; Glover, LE; Abdulla, ZI; Skelton, MR; Colgan, SP. Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function. Gastroenterology. 2020; 159:984-998.e1.

Miles, KN; Skelton, MR. Male mice placed on a ketogenic diet from postnatal day (P) 21 through adulthood have reduced growth, are hypoactive, show increased freezing in a conditioned fear paradigm, and have spatial learning deficits. Brain Research. 2020; 1734:146697.