Punam Malik, MD
- Director, Cincinnati Comprehensive Sickle Cell Center
- Program Leader, Hematology and Gene Therapy Program
- Marjory J. Johnson Chair, Gene and Cell Therapy
- Professor, UC Department of Pediatrics
- punam.malik@cchmc.org
- Board Certified
About
MBBS: University of Delhi, New Delhi, India, 1985.
MD: University of Delhi, New Delhi, India, 1989.
MS: University of Maryland, Baltimore, MD, 1991.
Fellowship: Children's Hospital Los Angeles, University of Southern California, 1995.
Services and Specialties
Cancer and Blood Diseases, Sickle Cell and Hemoglobin Disorders
Research Areas
Experimental Hematology and Cancer Biology, Cancer and Blood Diseases, Hematology
Insurance Information
Cincinnati Children's strives to accept a wide variety of health plans. Please contact your health insurance carrier to verify coverage for your specific benefit plan.
Publications
Underutilization of Disease-Modifying Therapies in Sickle Cell Disease: A Real-World Analysis from the ASH Research Collaborative Data Hub. Blood. 2024; 144:2312.
Blockade of Angiotensin II Signaling Ameliorates Cardiac Fibrosis and Improves Diastolic Dysfunction in Mice with Sickle Cell Anemia. Blood. 2024; 144:2480.
Splenic Ossification in Sickle Cell Anemia Mice. Blood. 2024; 144:5283.
A Novel Mouse Model of Hemoglobin-SC Disease: Bridging the Knowledge Gap in Sickle Cell Disease. Blood. 2024; 144:620.
Longitudinal Assessment of Myocardial Fibrosis in Sickle Cell Disease. Blood. 2024; 144:799.
Preclinical safety assessment of modified gamma globin lentiviral vector-mediated autologous hematopoietic stem cell gene therapy for hemoglobinopathies. PloS one. 2024; 19:e0306719.
NRASQ61R mutation drives elevated angiopoietin-2 expression in human endothelial cells and a genetic mouse model. Pediatric Blood and Cancer. 2024; 71:e31032.
CRISPR/Cas9 deletion of MIR155HG in human T cells reduces incidence and severity of acute GVHD in a xenogeneic model. Blood Advances. 2024; 8:947-958.
Generation of a tyrosine hydroxylase-2A-Cre knockin non-human primate model by homology-directed-repair-biased CRISPR genome editing. Cell Reports: Methods. 2023; 3:100590.
Strategies for precise gene edits in mammalian cells. Molecular Therapy-Nucleic Acids. 2023; 32:536-552.
From the Blog
Preventing Adult Sickle Cell Deaths From Kidney Disease May Start With Improved Childhood Testing
Punam Malik, MD, Omar Niss, MD4/15/2020
Gene Therapy Advances Raise Hopes for Curing Sickle Cell Disease
Punam Malik, MD6/27/2019
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