A photo of Benjamin Mantell.

Benjamin Mantell, MD, PhD


  • Member, Division of Cardiology
  • Assistant Professor, UC Department of Pediatrics
Supporting the entire family unit is as important as the medicines or devices that keep my patients alive.
Benjamin Mantell, MD, PhD

About

Biography

I am a pediatric cardiologist with a special interest in cardiomyopathy, heart failure and heart transplant. I entered this field with a passion for working with infants, children and adolescents who have severe heart disease. My team and I specialize in ways to improve heart function. These patients can often be supported with medications, although they sometimes require machines called ventricular assist devices to help the heart pump. In cases where medicines and machines are not enough, we support patients and their families to evaluate whether a heart transplant is the appropriate next step. It is a privilege to take care of these children and help them and their families through this often-times arduous journey. Supporting the entire family unit is as important as the medicines or devices that keep my patients alive.

I did not always know I wanted to become a doctor. I was exposed to doctors early in life; my grandmother was one of the first women physicians, a pediatrician who helped formulate the concept of family-centered care. However, I started toward this field with an interest in scientific research. During college, I developed a strong interest in understanding how the immune system works and interacts with many other normal functions of the body. Around this time, I was fortunate to work with Michael Sack, an MD, PhD cardiologist at the National Institutes of Health (NIH). We performed research on cells in culture, and he also ran clinical trials. This experience put much meaning behind our work at the bench and helped me decide to seek my own MD and PhD training.

In medical school, I combined all these experiences into an interest in heart transplantation. I subsequently trained in pediatrics at Cincinnati Children's, then specialized in pediatric cardiology and advanced heart failure/transplantation at Columbia University, New York, NY, where I was able to train under Dr. Linda Addonizio, one of the pioneers of pediatric heart transplantation.

My research aims to improve clinical outcomes for children with heart failure, pre- and post-heart transplantation, including those considered high risk for heart transplant. Specifically, I investigate various mechanisms of transplant rejection and the clinical outcomes of transplant patients who have pre-formed antibodies against their donor hearts (a process called pre-sensitization).

When I'm not at work, I love spending time with my wife, daughter and our puppy, playing tennis and exploring Cincinnati. I'm excited to return after a seven-year hiatus and show my family my favorite places from my training.

MD, PhD: University of Pittsburgh School of Medicine, Pittsburgh, PA, 2013.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2016.

Fellowship: Pediatric Cardiology, Morgan Stanley Children's Hospital, Columbia University Medical Center of NewYork-Presbyterian, 2019.

Fellowship: Pediatric Cardiomyopathy, Heart Failure and Transplantation, Morgan Stanley Children's Hospital, Columbia University Medical Center of NewYork-Presbyterian, 2020.

Certification: Pediatrics, 2017.

Certification: Pediatric Cardiology, 2020.

Interests

Pediatric cardiomyopathy, heart failure, heart transplantation and mechanical circulatory support

Services and Specialties

Heart Failure and Transplant Program, Cardiology Clinic

Interests

Mechanisms of transplant rejection; pre-sensitization; improving outcomes for pediatric patients with heart failure, both pre- and post-transplant

Insurance Information

Cincinnati Children's strives to accept a wide variety of health plans. Please contact your health insurance carrier to verify coverage for your specific benefit plan.

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Publications

Getting to Transplant Should Not Be the Goal. Morales, DL S; Mantell, BS. Journal of the American College of Cardiology. 2024; 84:633-634.

(506) Thymectomy Duration in Congenital Heart Disease Patients Correlates with Early Coronary Allograft Vasculopathy Development in Pediatric Heart Transplant. Ramineni, A; Hogue, S; Kulshrestha, K; Stark, S; Chin, C; Mantell, BS; Morales, DL; Moore, C. The Journal of Heart and Lung Transplantation. 2024; 43:s251.

Association Between High Sensitivity Troponin Levels Following Pediatric Orthotopic Heart Transplantation and Intensive Care Unit Resource Utilization. Butensky, AM; Desai, S; Dilorenzo, M; Lytrivi, ID; Mantell, BS; Zhang, Y; Choudhury, TA. Pediatric Cardiology. 2024; 45:829-839.

(294) How Could DCD Heart Donation Affect Organ Availability for Congenital Heart Programs?. Cheon, S; Kulshrestha, K; Ahmed, HF; Mantell, BS; Chin, C; Morales, D; Ashfaq, A. The Journal of Heart and Lung Transplantation. 2024; 43:s152-s153.

Risk factors for 1-year allograft loss in pediatric heart transplant patients using machine learning: An analysis of the pediatric heart transplant society database. Wisotzkey, BL; Jaeger, B; Asante-Korang, A; Brickler, M; Cantor, RS; Everitt, MD; Kirklin, JK; Koehl, D; Mantell, BS; Thrush, PT; Kuhn, M. Pediatric Transplantation. 2023; 27:e14612.

The Fontan immunophenotype and post-transplant outcomes in children: A multi-institutional study. Mantell, BS; Azeka, E; Cantor, RS; Carlo, WF; Chrisant, M; Dykes, JC; Hoffman, TM; Kirklin, JK; Koehl, D; L'Ecuyer, TJ; McAllister, JM; Prada-Ruiz, AC; Richmond, ME. Pediatric Transplantation. 2023; 27:e14456.

Immune cell function assay and T lymphocyte counts lack association with rejection or infection in pediatric heart transplant recipients. Chen, JK; Salerno, DM; Corbo, H; Mantell, BS; Richmond, M; Rothkopf, A; Lytrivi, ID. Clinical Transplantation. 2023; 37:e14858.

Transcriptomic heterogeneity of antibody mediated rejection after heart transplant with or without donor specific antibodies. Mantell, BS; Cordero, H; See, SB; Clerkin, KJ; Vasilescu, R; Marboe, CC; Naka, Y; Restaino, S; Colombo, PC; Addonizio, LJ; Farr, MA; Zorn, E. The Journal of Heart and Lung Transplantation. 2021; 40:1472-1480.

Spectrum of clinical presentation of COVID-19 in paediatric patients with cardiomyopathy and heart failure. Mantell, BS; Lytrivi, ID; Lee, TM. Cardiology in the Young. 2021; 31:1348-1349.

Varying presentations of COVID-19 in young heart transplant recipients: A case series. Lee, H; Mantell, BS; Richmond, ME; Law, SP; Zuckerman, WA; Addonizio, LJ; Lee, TM; Lytrivi, ID. Pediatric Transplantation. 2020; 24:e13780.

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4.6
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