BSc: Co-major in genetics and biochemistry, University of Melbourne, Australia, 1984 (with honors).
PhD: University of Melbourne, Australia, at the Ludwig Institute for Cancer Research under Drs. AR Dunn and TJ Gonda, 1988.
Postdoctoral Fellow: The G.W. Hooper Research Foundation, University of California, San Francisco under Dr. JM Bishop, 1989-92. Studied the role of the macrophage in developmentally programmed tissue remodeling.
The OPN3, OPN4 and OPN5 light sensing pathways in development, homeostasis and disease
Ophthalmology, Developmental Biology
Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice. Proceedings of the National Academy of Sciences of USA. 2021; 118.
Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons. Nature. 2020; 585:420-425.
Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing. Cell Reports. 2020; 30:672-686.e8.
Neuropsin (OPN5) Mediates Local Light-Dependent Induction of Circadian Clock Genes and Circadian Photoentrainment in Exposed Murine Skin. Current Biology. 2019; 29:3478-3487.e4.
An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye. Nature Cell Biology. 2019; 21:420-429.
A direct and melanopsin-dependent fetal light response regulates mouse eye development. Nature. 2013; 494:243-246.
Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia. Proceedings of the National Academy of Sciences of USA. 2011; 108:18289-18294.
Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature. 2011; 474:511-515.
Macrophage Wnt7b is critical for kidney repair and regeneration. Proceedings of the National Academy of Sciences of USA. 2010; 107:4194-4199.
WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature. 2005; 437:417-421.
Richard A. Lang, PhD8/14/2024
Richard A. Lang, PhD, James M. Greenberg, MD ...8/3/2021
Richard A. Lang, PhD5/24/2021
Richard A. Lang, PhD9/2/2020
Richard A. Lang, PhD, John Hogenesch, PhD ...2/4/2020
Richard A. Lang, PhD1/21/2020